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Title
Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 9, Pages 4716
Publisher
MDPI AG
Online
2021-04-29
DOI
10.3390/ijms22094716
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- (2021) Jie Tang et al. ACTA PHARMACOLOGICA SINICA
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- (2021) Laure Perrin-Cocon et al. Communications Biology
- Challenge to overcome current limitations of cell-penetrating peptides
- (2021) Gyu Chan Kim et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
- (2021) Xun Shangguan et al. Nature Communications
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- (2020) Marta Anna Kowalik et al. JOURNAL OF HEPATOLOGY
- mTOR at the nexus of nutrition, growth, ageing and disease
- (2020) Grace Y. Liu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca 2+ ‐dependent death of cancer cells
- (2020) Francesco Ciscato et al. EMBO REPORTS
- Autophagy in cancer: Recent advances and future directions
- (2020) Mohd Ishaq et al. SEMINARS IN CANCER BIOLOGY
- Hypoxia‐inducible hexokinase‐2 enhances anti‐apoptotic function via activating autophagy in multiple myeloma
- (2020) Sho Ikeda et al. CANCER SCIENCE
- PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling
- (2020) Timothy R. Baffi et al. Annual Review of Pharmacology and Toxicology
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- (2020) Kensuke Tateishi et al. CANCER RESEARCH
- Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
- (2019) Tengjiao Fan et al. Cancers
- Hexokinase-II Inhibition Synergistically Augments the Anti-tumor Efficacy of Sorafenib in Hepatocellular Carcinoma
- (2019) Jeong-Ju Yoo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis
- (2019) Clotilde Wiel et al. CELL
- AKT2 phosphorylation of hexokinase 2 at T473 promotes tumorigenesis and metastasis in colon cancer cells via NF-κB, HIF1α, MMP2, and MMP9 upregulation
- (2019) Hang Li et al. CELLULAR SIGNALLING
- Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion
- (2019) Hong-Jen Lee et al. Nature Communications
- The Metabolic Signature of Macrophage Responses
- (2019) Antonella Viola et al. Frontiers in Immunology
- Dissociation of mitochondrial HK-II elicits mitophagy and confers cardioprotection against ischemia
- (2019) Valerie P. Tan et al. Cell Death & Disease
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- (2019) Kun Fan et al. Cancer Medicine
- IP3 Receptor Plasticity Underlying Diverse Functions
- (2019) Kozo Hamada et al. Annual Review of Physiology
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- (2019) Shuo Liu et al. Human Cell
- Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-β
- (2019) Xueqian Yin et al. Science Signaling
- MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect
- (2018) Ying Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy
- (2018) Xiao-Yan Zhang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer
- (2018) Tingting Yang et al. ONCOGENE
- Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
- (2018) Dannielle DeWaal et al. Nature Communications
- Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL
- (2018) Kavita Bhalla et al. Scientific Reports
- Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation
- (2018) Veronique Nogueira et al. eLife
- Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings
- (2018) Giampaolo Morciano et al. NEOPLASIA
- VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis
- (2018) Andrea Magrì et al. Frontiers in Chemistry
- Metabolic Plasticity of Tumor Cell Mitochondria
- (2018) Giuseppe Cannino et al. Frontiers in Oncology
- Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells
- (2018) Sameer Agnihotri et al. CLINICAL CANCER RESEARCH
- Unlocking the potential of HK2 in cancer metabolism and therapeutics
- (2018) Sara N. Garcia et al. CURRENT MEDICINAL CHEMISTRY
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- (2018) Ying Li et al. FREE RADICAL BIOLOGY AND MEDICINE
- Reciprocal role of SIRT6 and Hexokinase 2 in the regulation of autophagy driven monocyte differentiation
- (2017) Ankita Singh et al. EXPERIMENTAL CELL RESEARCH
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- (2017) Pengchun Yu et al. NATURE
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- (2017) Juan J. Gu et al. Oncotarget
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- (2017) Jiayuan Wu et al. Oncotarget
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- (2017) Fangfang Jin et al. Scientific Reports
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- (2016) Andrea J. Wolf et al. CELL
- The ever-expanding role of HIF in tumour and stromal biology
- (2016) Edward L. LaGory et al. NATURE CELL BIOLOGY
- Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma
- (2016) Alenoush Vartanian et al. Oncotarget
- Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis
- (2016) Marta Anna Kowalik et al. Oncotarget
- Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria
- (2016) César Cárdenas et al. Cell Reports
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- (2015) Guillaume Calmettes et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
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- (2015) Paolo Bernardi et al. PHYSIOLOGICAL REVIEWS
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- (2014) D J Roberts et al. CELL DEATH AND DIFFERENTIATION
- Glycolysis inhibition and its effect in doxorubicin resistance in neuroblastoma
- (2014) Jonathan F. Bean et al. JOURNAL OF PEDIATRIC SURGERY
- Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition
- (2014) David J. Roberts et al. MOLECULAR CELL
- The Reversal Effects of 3-Bromopyruvate on Multidrug Resistance In Vitro and In Vivo Derived from Human Breast MCF-7/ADR Cells
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- (2013) David J. Roberts et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
- (2013) Gregg L. Semenza JOURNAL OF CLINICAL INVESTIGATION
- mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
- (2013) C. Betz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2013) B Pantic et al. Cell Death & Disease
- Cardiac‐specific Hexokinase 2 Overexpression Attenuates Hypertrophy by Increasing Pentose Phosphate Pathway Flux
- (2013) Kyle S. McCommis et al. Journal of the American Heart Association
- GSK-3 and mitochondria in cancer cells
- (2013) Federica Chiara et al. Frontiers in Oncology
- Induction of the permeability transition pore in cells depleted of mitochondrial DNA
- (2012) Ionica Masgras et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
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- (2012) Q. Zhang et al. Cancer Prevention Research
- Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production
- (2012) Rongxue Wu et al. EMBO Molecular Medicine
- MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
- (2012) Kivanç Birsoy et al. NATURE GENETICS
- miR-143 regulates hexokinase 2 expression in cancer cells
- (2012) A Peschiaroli et al. ONCOGENE
- Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death
- (2012) E. C. Cheung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis
- (2011) Andrea Rasola et al. CELL CALCIUM
- Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
- (2011) Amparo Wolf et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies
- (2010) Saroj P. Mathupala et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- A therapeutic role for targeting c-Myc/Hif-1- dependent signaling pathways
- (2010) Klaus Podar et al. CELL CYCLE
- PHLPP-1 Negatively Regulates Akt Activity and Survival in the Heart
- (2010) Shigeki Miyamoto et al. CIRCULATION RESEARCH
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- (2010) Rongxue Wu et al. CIRCULATION RESEARCH
- Signal transduction to the permeability transition pore
- (2010) Andrea Rasola et al. FEBS LETTERS
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- (2010) Irina V. Perevoshchikova et al. FEBS LETTERS
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- (2010) Juan Carlos Corona et al. JOURNAL OF NEUROSCIENCE RESEARCH
- In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer
- (2009) Emilia S. Olson et al. Integrative Biology
- Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides
- (2009) Todd A. Aguilera et al. Integrative Biology
- mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3 Inhibition
- (2009) P. T. Bhaskar et al. MOLECULAR AND CELLULAR BIOLOGY
- Voltage-dependent Anion Channel 1-based Peptides Interact with Hexokinase to Prevent Its Anti-apoptotic Activity
- (2008) Laetitia Arzoine et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels
- (2008) Federica Chiara et al. PLoS One
- Molecular evolution of the vertebrate hexokinase gene family: Identification of a conserved fifth vertebrate hexokinase gene
- (2007) David M. Irwin et al. Comparative Biochemistry and Physiology D-Genomics & Proteomics
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