Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells – A potential contribution to the predictive, preventive, and personalized medicine

Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis

(2022) Haili Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Baicalein: A review on its anti‐cancer effects and mechanisms in lung carcinoma

(2022) Naveenkumar Chandrashekar et al.   JOURNAL OF FOOD BIOCHEMISTRY

Prostate cancer treatment costs increase more rapidly than for any other cancer—how to reverse the trend?

(2022) J. Ellinger et al.   EPMA Journal

Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care

(2022) Alena Mazurakova et al.   EPMA Journal

Mitochondrial health quality control: measurements and interpretation in the framework of predictive, preventive, and personalized medicine

(2022) Lenka Koklesova et al.   EPMA Journal

Baicalein Inhibits the Progression and Promotes Radiosensitivity of Esophageal Squamous Cell Carcinoma by Targeting HIF-1A

(2022) Dongli Guo et al.   Drug Design Development and Therapy

The Juggernaut of Adaptive Metabolism in Cancers: Implications and Therapeutic Targets

(2022) Samson Mathews Samuel et al.   Cancers

Flavonoids Targeting HIF-1: Implications on Cancer Metabolism

(2021) Marek Samec et al.   Cancers

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hypoxia-induced therapy resistance: Available hypoxia-targeting strategies and current advances in head and neck cancer

(2021) Victoria L. Codony et al.   Translational Oncology

Altered glycolysis results in drug‑resistant in clinical tumor therapy (Review)

(2021) Jinghui Peng et al.   Oncology Letters

Glycolysis-induced drug resistance in tumors—A response to danger signals?

(2021) Fabrizio Marcucci et al.   NEOPLASIA

Flavonoids against the SARS-CoV-2 induced inflammatory storm

(2021) Alena Liskova et al.   BIOMEDICINE & PHARMACOTHERAPY

Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target

(2021) Vittoria Infantino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting Lactate Dehydrogenase A with Catechin Resensitizes SNU620/5FU Gastric Cancer Cells to 5-Fluorouracil

(2021) Jung Ho Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overcoming chemotherapy resistance using pH-sensitive hollow MnO2 nanoshells that target the hypoxic tumor microenvironment of metastasized oral squamous cell carcinoma

(2021) Zhi-hang Zhou et al.   JOURNAL OF NANOBIOTECHNOLOGY

Glucose transporter‑1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells

(2021) Takafumi Shima et al.   ONCOLOGY REPORTS

Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways

(2021) Peter Kubatka et al.   EPMA Journal

Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine

(2021) Xianquan Zhan et al.   EPMA Journal

Baicalein resensitizes tamoxifen‐resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia‐inducible factor‐1α

(2021) Yan Chen et al.   Clinical and Translational Medicine

Apigenin as an anticancer agent

(2020) Muhammad Imran et al.   PHYTOTHERAPY RESEARCH

Overcoming the hypoxia-induced drug resistance in liver tumor by the concurrent use of apigenin and paclitaxel

(2020) Ke Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses

(2020) Peter Kubatka et al.   MOLECULES

Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma

(2020) Oluwaseun Adebayo Bamodu et al.   Cells

Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer

(2020) Elizabeth Varghese et al.   Cancers

Flavonoids in Cancer Metastasis

(2020) Alena Liskova et al.   Cancers

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

(2020) Marek Samec et al.   EPMA Journal

Silibinin down-regulates PD-L1 expression in nasopharyngeal carcinoma by interfering with tumor cell glycolytic metabolism

(2020) Leïla Sarah Sellam et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1

(2020) Sarah Hassan et al.   PLoS One

Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back

(2020) Lenka Koklesova et al.   Cancers

Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma

(2020) Peter Kubatka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

(2019) Ichrak Riahi-Chebbi et al.   Scientific Reports

Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells

(2019) ZiSheng Chen et al.   Frontiers in Pharmacology

Baicalein Suppresses Stem Cell-Like Characteristics in Radio- and Chemoresistant MDA-MB-231 Human Breast Cancer Cells through Up-Regulation of IFIT2

(2019) So Koh et al.   Nutrients

Oroxylin A increases the sensitivity of temozolomide on glioma cells by hypoxia-inducible factor 1α/hedgehog pathway under hypoxia

(2019) Mian Wei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Controlling metastatic cancer: the role of phytochemicals in cell signaling

(2019) Andrea Kapinova et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Hypoxia/pseudohypoxia‐mediated activation of hypoxia‐inducible factor‐1α in cancer

(2019) Yoshihiro Hayashi et al.   CANCER SCIENCE

Anticancer Activities of Thymus vulgaris L. in Experimental Breast Carcinoma in Vivo and in Vitro

(2019) Kubatka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Receptor tyrosine kinases in PI3K signaling: The therapeutic targets in cancer

(2019) Wei Jiang et al.   SEMINARS IN CANCER BIOLOGY

Devimistat in combination with high dose cytarabine and mitoxantrone compared with high dose cytarabine and mitoxantrone in older patients with relapsed/refractory acute myeloid leukemia: ARMADA 2000 Phase III study

(2019) Timothy S Pardee et al.   Future Oncology

Elevated Hexokinase II Expression Confers Acquired Resistance to 4-Hydroxytamoxifen in Breast Cancer Cells

(2019) Xiaochuan Liu et al.   MOLECULAR & CELLULAR PROTEOMICS

Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis

(2019) Benjamin L. Woolbright et al.   MOLECULAR CANCER THERAPEUTICS

Wogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway

(2019) Feng Xing et al.   MEDICAL SCIENCE MONITOR

Hexokinase 2 dimerization and interaction with voltage‐dependent anion channel promoted resistance to cell apoptosis induced by gemcitabine in pancreatic cancer

(2019) Kun Fan et al.   Cancer Medicine

Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells

(2019) Chieh-Yu Lan et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Effect of pyruvate kinase M2-regulating aerobic glycolysis on chemotherapy resistance of estrogen receptor-positive breast cancer

(2018) Yuejun Qian et al.   ANTI-CANCER DRUGS

PKM2 under hypoxic environment causes resistance to mTOR inhibitor in human castration resistant prostate cancer

(2018) Yota Yasumizu et al.   Oncotarget

Pyruvate dehydrogenase kinase 1 contributes to cisplatin resistance of ovarian cancer through EGFR activation

(2018) Meng Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Anticancer potential of quercetin: A comprehensive review

(2018) Abdur Rauf et al.   PHYTOTHERAPY RESEARCH

The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells

(2018) Marcella Manerba et al.   PLoS One

Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells

(2018) Shuhei Suzuki et al.   Oncotarget

Vicenin-2 acts as a radiosensitizer of the non-small cell lung cancer by lowering Akt expression

(2018) Taranga Jyoti Baruah et al.   BIOFACTORS

Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

(2018) Muhammad Imran et al.   PHYTOTHERAPY RESEARCH

Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro

(2018) Tao Jiang et al.   OncoTargets and Therapy

Flavonoids in Cancer and Apoptosis

(2018) Mariam Abotaleb et al.   Cancers

Metformin increases sensitivity of osteosarcoma stem cells to cisplatin by inhibiting expression of PKM2

(2017) Depeng Shang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Flavonoids: From Structure to Health Issues

(2017) Celestino Santos-Buelga et al.   MOLECULES

The In Vitro and In Vivo Antiangiogenic Effects of Flavokawain B

(2017) Mariana C. Rossette et al.   PHYTOTHERAPY RESEARCH

HIF1/2α mediates hypoxia-induced LDHA expression in human pancreatic cancer cells

(2017) Xin-gang Cui et al.   Oncotarget

Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification?

(2017) Olga Golubnitschaja   EPMA Journal

Breast cancer and Flammer syndrome: any symptoms in common for prediction, prevention and personalised medical approach?

(2017) Pavol Zubor et al.   EPMA Journal

“Pre-metastatic niches” in breast cancer: are they created by or prior to the tumour onset? “Flammer Syndrome” relevance to address the question

(2017) Rostyslav Bubnov et al.   EPMA Journal

PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer

(2017) Chao Wang et al.   Scientific Reports

Inhibition of Glut1 by WZB117 sensitizes radioresistant breast cancer cells to irradiation

(2016) Fei Zhao et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt’s lymphoma

(2016) Marisa Granato et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of the PI3K/AKT/mTOR Pathway in Solid Tumors

(2016) Patricia Mucci LoRusso   JOURNAL OF CLINICAL ONCOLOGY

A specific inhibitor of lactate dehydrogenase overcame the resistance toward gemcitabine in hypoxic mesothelioma cells, and modulated the expression of the human equilibrative transporter-1

(2016) Elisa Giovannetti et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection

(2015) Valerie P Tan et al.   Autophagy

Hispidulin inhibits proliferation and enhances chemosensitivity of gallbladder cancer cells by targeting HIF-1α

(2015) Hui Gao et al.   EXPERIMENTAL CELL RESEARCH

HIF-1 at the crossroads of hypoxia, inflammation, and cancer

(2015) Kuppusamy Balamurugan   INTERNATIONAL JOURNAL OF CANCER

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1  Phosphorylation

(2015) G. J. Cerniglia et al.   MOLECULAR CANCER THERAPEUTICS

Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo

(2015) YANG-YANG BAO et al.   ONCOLOGY REPORTS

Hypoxia-inducible factor-1α induces multidrug resistance protein in colon cancer

(2015) Yingqian Lv et al.   OncoTargets and Therapy

High Expression of Pyruvate Kinase M2 is Associated with Chemosensitivity to Epirubicin and 5-Fluorouracil in Breast Cancer

(2015) Yang Lin et al.   Journal of Cancer

Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells

(2015) Yu Mi Woo et al.   PLoS One

Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil

(2014) XIANGYONG LI et al.   Molecular Medicine Reports

Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1α signaling pathway

(2014) FENGLIN CHEN et al.   ONCOLOGY REPORTS

Flammer syndrome

(2014) Katarzyna Konieczka et al.   EPMA Journal

Targeting PI3K/Akt represses Hypoxia inducible factor-1α activation and sensitizes Rhabdomyosarcoma and Ewing’s sarcoma cells for apoptosis

(2013) Mehtap Kilic-Eren et al.   Cancer Cell International

Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy

(2013) George S Krasnov et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway

(2013) Hu Wang et al.   MOLECULAR CARCINOGENESIS

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT