Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma

Treatment Strategies for Hepatocellular Carcinoma – a Multidisciplinary Approach

(2019) Isabella Lurje et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alterations in DNA damage repair genes in primary liver cancer

(2019) Jianzhen Lin et al.   CLINICAL CANCER RESEARCH

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

Contribution of Epithelial Plasticity to Therapy Resistance

(2019) Patricia G. Santamaría et al.   Journal of Clinical Medicine

LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85

(2018) Shuangbing Xu et al.   CANCER LETTERS

PDK1: At the crossroad of cancer signaling pathways

(2018) Paolo Armando Gagliardi et al.   SEMINARS IN CANCER BIOLOGY

New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response

(2018) Klaudia Szymonowicz et al.   Cancers

Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells

(2018) Francis O. Enane et al.   Cell Death & Disease

Protein Kinases in Pluripotency—Beyond the Usual Suspects

(2017) Rosalia Fernandez-Alonso et al.   JOURNAL OF MOLECULAR BIOLOGY

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level

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Targeting PDK1 for Chemosensitization of Cancer Cells

(2017) Aikaterini Emmanouilidi et al.   Cancers

Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination

(2017) Laura Di Blasio et al.   Cancers

EMT and Treatment Resistance in Pancreatic Cancer

(2017) Nicola Gaianigo et al.   Cancers

The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy

(2015) Michael Goldstein et al.   Annual Review of Medicine

Aldehyde Dehydrogenase Is Regulated by  -Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells

(2015) M. Cojoc et al.   CANCER RESEARCH

Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma

(2015) Dominik Horn et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Biological Consequences of Radiation-induced DNA Damage: Relevance to Radiotherapy

(2013) M.E. Lomax et al.   CLINICAL ONCOLOGY

Acquisition of epithelial–mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance

(2013) L Chang et al.   Cell Death & Disease

PDK1 Signaling Toward PLK1-MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy

(2013) J. Tan et al.   Cancer Discovery

Hepatocellular Carcinoma Radiation Therapy: Review of Evidence and Future Opportunities

(2012) Jonathan Klein et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Targeting PDK1 in Cancer

(2011) C. Raimondi et al.   CURRENT MEDICINAL CHEMISTRY

Targeted Therapies for Hepatocellular Carcinoma

(2011) Augusto Villanueva et al.   GASTROENTEROLOGY

Inducible and repressable oncogene-addicted hepatocellular carcinoma in Tet-on xmrk transgenic zebrafish

(2011) Zhen Li et al.   JOURNAL OF HEPATOLOGY

The (un)targeted cancer kinome

(2010) Oleg Fedorov et al.   Nature Chemical Biology

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

DNA-dependent Protein Kinase-mediated Phosphorylation of Protein Kinase B Requires a Specific Recognition Sequence in the C-terminal Hydrophobic Motif

(2009) Jongsun Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogene Addiction

(2008) I. B. Weinstein et al.   CANCER RESEARCH