Psychedelic therapy in the treatment of addiction: the past, present and future

Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder

(2022) Meryem Grabski et al.   AMERICAN JOURNAL OF PSYCHIATRY

Exploring protective associations between the use of classic psychedelics and cocaine use disorder: a population-based survey study

(2022) Grant M. Jones et al.   Scientific Reports

Increased global integration in the brain after psilocybin therapy for depression

(2022) Richard E. Daws et al.   NATURE MEDICINE

Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses

(2022) Drummond E-Wen McCulloch et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies

(2022) Javier Calleja‐Conde et al.   ADDICTION BIOLOGY

BRAIN SEROTONIN RELEASE IS REDUCED IN PATIENTS WITH DEPRESSION: A [11C]Cimbi-36 PET STUDY WITH A D-AMPHETAMINE CHALLENGE.

(2022) David Erritzoe et al.   BIOLOGICAL PSYCHIATRY

Default Mode Network Modulation by Psychedelics: A Systematic Review

(2022) James J Gattuso et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Mescaline: The forgotten psychedelic

(2022) Ioanna A. Vamvakopoulou et al.   NEUROPHARMACOLOGY

Psychedelics therapeutics: What we know, what we think, and what we need to research.

(2022) David Nutt et al.   NEUROPHARMACOLOGY

Towards an understanding of psychedelic-induced neuroplasticity

(2022) Abigail E. Calder et al.   NEUROPSYCHOPHARMACOLOGY

Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity

(2022) James Glazer et al.   NEUROPSYCHOPHARMACOLOGY

Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder

(2022) Michael P. Bogenschutz et al.   JAMA Psychiatry

Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence

(2022) Ioanna A. Vamvakopoulou et al.   Frontiers in Psychiatry

Towards mapping neuro-behavioral heterogeneity of psychedelic neurobiology in humans

(2022) Flora Moujaes et al.   BIOLOGICAL PSYCHIATRY

Psychedelics and Neural Plasticity: Therapeutic Implications

(2022) Steven F. Grieco et al.   JOURNAL OF NEUROSCIENCE

Changes in music-evoked emotion and ventral striatal functional connectivity after psilocybin therapy for depression

(2022) Melissa Shukuroglou et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Canalization and plasticity in psychopathology

(2022) R.L. Carhart-Harris et al.   NEUROPHARMACOLOGY

A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain

(2021) Nakul Ravi Raval et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

First study of safety and tolerability of 3,4-methylenedioxymethamphetamine-assisted psychotherapy in patients with alcohol use disorder

(2021) Ben Sessa et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Can pragmatic research, real-world data and digital technologies aid the development of psychedelic medicine?

(2021) Robin L Carhart-Harris et al.   JOURNAL OF PSYCHOPHARMACOLOGY

MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

(2021) Jennifer M. Mitchell et al.   NATURE MEDICINE

Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11 C‐UCB‐J positron emission tomography study in humans

(2021) Gustavo A. Angarita et al.   ADDICTION BIOLOGY

A narrative synthesis of research with 5-MeO-DMT

(2021) Anna O Ermakova et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder

(2021) Manoj K. Doss et al.   Translational Psychiatry

Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism

(2021) Marcus W. Meinhardt et al.   Science Advances

Couple Therapy With MDMA—Proposed Pathways of Action

(2021) Anne C. Wagner   Frontiers in Psychology

Psychedelic use is associated with reduced daily opioid use among people who use illicit drugs in a Canadian setting

(2021) Elena Argento et al.   INTERNATIONAL JOURNAL OF DRUG POLICY

Therapeutic mechanisms of psilocybin: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression

(2020) Lea J Mertens et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials

(2020) Juan José Fuentes et al.   Frontiers in Psychiatry

Persisting Reductions in Cannabis, Opioid, and Stimulant Misuse After Naturalistic Psychedelic Use: An Online Survey

(2020) Albert Garcia-Romeu et al.   Frontiers in Psychiatry

Evidenced-Based Pharmacotherapies for Alcohol Use Disorder

(2020) Jeremiah Fairbanks et al.   MAYO CLINIC PROCEEDINGS

Disturbances across whole brain networks during reward anticipation in an abstinent addiction population

(2020) Liam J Nestor et al.   NeuroImage-Clinical

Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern‐era clinical studies

(2020) Kristoffer A. A. Andersen et al.   ACTA PSYCHIATRICA SCANDINAVICA

A non-hallucinogenic psychedelic analogue with therapeutic potential

(2020) Lindsay P. Cameron et al.   NATURE

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

(2019) Soledad Marton et al.   Frontiers in Pharmacology

Cessation and reduction in alcohol consumption and misuse after psychedelic use

(2019) Albert Garcia-Romeu et al.   JOURNAL OF PSYCHOPHARMACOLOGY

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials

(2019) Michael C. Mithoefer et al.   PSYCHOPHARMACOLOGY

A Review of 3,4-methylenedioxymethamphetamine (MDMA)-Assisted Psychotherapy

(2019) Ben Sessa et al.   Frontiers in Psychiatry

LSD acutely impairs working memory, executive functions, and cognitive flexibility, but not risk-based decision-making

(2019) Thomas Pokorny et al.   PSYCHOLOGICAL MEDICINE

Ketamine and depression: a narrative review

(2019) Alexandrine Corriger et al.   Drug Design Development and Therapy

Brain default-mode network dysfunction in addiction

(2019) Rui Zhang et al.   NEUROIMAGE

Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge

(2019) David Erritzoe et al.   NEUROPSYCHOPHARMACOLOGY

Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories

(2019) Ravi K. Das et al.   Nature Communications

A Single Ketamine Infusion Combined With Motivational Enhancement Therapy for Alcohol Use Disorder: A Randomized Midazolam-Controlled Pilot Trial

(2019) Elias Dakwar et al.   AMERICAN JOURNAL OF PSYCHIATRY

State and trait characteristics of anterior insula time-varying functional connectivity

(2019) Lorenzo Pasquini et al.   NEUROIMAGE

Psilocybin modulates functional connectivity of the amygdala during emotional face discrimination

(2018) O. Grimm et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Gaps in the Substance Use Disorder Treatment Referral Process

(2018) Claire E. Blevins et al.   Journal of Addiction Medicine

The epidemiology of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption

(2018) Alan K Davis et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals

(2018) Samuel Turton et al.   MOLECULAR PSYCHIATRY

Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review

(2018) Anna Zilverstand et al.   NEURON

Ketamine for the treatment of addiction: Evidence and potential mechanisms

(2018) I. Ivan Ezquerra-Romano et al.   NEUROPHARMACOLOGY

Toward biomarkers of the addicted human brain: Using neuroimaging to predict relapse and sustained abstinence in substance use disorder

(2018) Scott J. Moeller et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes

(2018) Deborah C. Mash et al.   Frontiers in Pharmacology

Assessment of Alcohol and Tobacco Use Disorders Among Religious Users of Ayahuasca

(2018) Paulo Cesar Ribeiro Barbosa et al.   Frontiers in Psychiatry

Mesolimbic Dopamine Function is Related to Salience Network Connectivity: An Integrative PET and MR Study

(2018) Robert A. McCutcheon et al.   BIOLOGICAL PSYCHIATRY

Resting parasympathetic dysfunction predicts prosocial helping deficits in behavioral variant frontotemporal dementia

(2018) Virginia E. Sturm et al.   CORTEX

Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and polysubstance-dependent individuals

(2018) Liam J. Nestor et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

NIDA’s medication development priorities in response to the Opioid Crisis: ten most wanted

(2018) Kurt Rasmussen et al.   NEUROPSYCHOPHARMACOLOGY

Prevalence, Treatment, And Unmet Treatment Needs Of US Adults With Mental Health And Substance Use Disorders

(2017) Beth Han et al.   HEALTH AFFAIRS

Effect of Psilocybin on Empathy and Moral Decision-Making

(2017) Thomas Pokorny et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The association of psychedelic use and opioid use disorders among illicit users in the United States

(2017) Vincent D Pisano et al.   JOURNAL OF PSYCHOPHARMACOLOGY

An online survey of tobacco smoking cessation associated with naturalistic psychedelic use

(2017) Matthew W Johnson et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression

(2017) Leor Roseman et al.   NEUROPHARMACOLOGY

Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence

(2017) Anna Murphy et al.   NEUROPSYCHOPHARMACOLOGY

Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior

(2017) Pierre Trifilieff et al.   SEMINARS IN NUCLEAR MEDICINE

Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study

(2017) Geoffrey E. Noller et al.   AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE

Disruption of Reward Processing in Addiction

(2017) Maartje Luijten et al.   JAMA Psychiatry

Association of Stimulant Use With Dopaminergic Alterations in Users of Cocaine, Amphetamine, or Methamphetamine

(2017) Abhishekh H. Ashok et al.   JAMA Psychiatry

Neural substrates of cue reactivity and craving in gambling disorder

(2017) E H Limbrick-Oldfield et al.   Translational Psychiatry

Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity

(2016) Inge Mick et al.   ADDICTION BIOLOGY

Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task

(2016) Liam J Nestor et al.   ADDICTION BIOLOGY

LSD-induced entropic brain activity predicts subsequent personality change

(2016) A.V. Lebedev et al.   HUMAN BRAIN MAPPING

The ICCAM platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part B: fMRI description

(2016) John McGonigle et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery

(2016) Iris M Balodis et al.   NEUROPSYCHOPHARMACOLOGY

LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality

(2016) Patrick C Dolder et al.   NEUROPSYCHOPHARMACOLOGY

Impulsivity in abstinent alcohol and polydrug dependence: a multidimensional approach

(2016) Eleanor M. Taylor et al.   PSYCHOPHARMACOLOGY

Improving GHB withdrawal with baclofen: study protocol for a feasibility study for a randomised controlled trial

(2016) Anne Lingford-Hughes et al.   Trials

Long-term follow-up of psilocybin-facilitated smoking cessation

(2016) Matthew W. Johnson et al.   AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE

The mixed serotonin receptor agonist psilocybin reduces threat-induced modulation of amygdala connectivity

(2016) Rainer Kraehenmann et al.   NeuroImage-Clinical

Neural substrates of cue reactivity: association with treatment outcomes and relapse

(2015) Kelly E. Courtney et al.   ADDICTION BIOLOGY

Finding the self by losing the self: Neural correlates of ego-dissolution under psilocybin

(2015) Alexander V. Lebedev et al.   HUMAN BRAIN MAPPING

The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description

(2015) Louise M Paterson et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study

(2015) Michael P Bogenschutz et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The dopamine theory of addiction: 40 years of highs and lows

(2015) David J. Nutt et al.   NATURE REVIEWS NEUROSCIENCE

Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers

(2015) Inge Mick et al.   NEUROPSYCHOPHARMACOLOGY

Pharmacotherapy for Alcohol Use Disorder

(2015) Robert M. Swift et al.   HARVARD REVIEW OF PSYCHIATRY

Illegal Drugs Laws: Clearing a 50-Year-Old Obstacle to Research

(2015) David Nutt   PLOS BIOLOGY

Resting-State Functional Connectivity in Psychiatric Disorders

(2015) Neil D. Woodward et al.   JAMA Psychiatry

Pharmacological Treatments for Smoking Cessation

(2014) Kate Cahill et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction

(2014) Matthew W Johnson et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Salience processing and insular cortical function and dysfunction

(2014) Lucina Q. Uddin   NATURE REVIEWS NEUROSCIENCE

In Vivo Imaging of Cerebral Dopamine D3 Receptors in Alcoholism

(2014) David Erritzoe et al.   NEUROPSYCHOPHARMACOLOGY

The Neural Mechanisms Underlying the Acute Effect of Cigarette Smoking on Chronic Smokers

(2014) Kangcheng Wang et al.   PLoS One

Characterization of [11C]Cimbi-36 as an agonist PET radioligand for the 5-HT2A and 5-HT2C receptors in the nonhuman primate brain

(2013) Sjoerd J. Finnema et al.   NEUROIMAGE

Visceral Influences on Brain and Behavior

(2013) Hugo D. Critchley et al.   NEURON

Processing of primary and secondary rewards: A quantitative meta-analysis and review of human functional neuroimaging studies

(2013) Guillaume Sescousse et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Factors modulating neural reactivity to drug cues in addiction: A survey of human neuroimaging studies

(2013) Agnes J. Jasinska et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Endogenous Opioid Release in the Human Brain Reward System Induced by Acute Amphetamine Administration

(2012) Alessandro Colasanti et al.   BIOLOGICAL PSYCHIATRY

Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials

(2012) Teri S Krebs et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Striatal dopamine D2/D3 receptor binding in pathological gambling is correlated with mood-related impulsivity

(2012) Luke Clark et al.   NEUROIMAGE

Resting state functional connectivity in addiction: Lessons learned and a road ahead

(2012) Matthew T. Sutherland et al.   NEUROIMAGE

History of cigarette smoking is associated with higher limbic GABAA receptor availability

(2012) Paul R.A. Stokes et al.   NEUROIMAGE

Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

(2012) Robin L. Carhart-Harris et al.   SCHIZOPHRENIA BULLETIN

The neurobiology of cognitive control in successful cocaine abstinence

(2011) Colm G. Connolly et al.   DRUG AND ALCOHOL DEPENDENCE

Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications

(2011) Rita Z. Goldstein et al.   NATURE REVIEWS NEUROSCIENCE

Neural substrates of smoking cue reactivity: A meta-analysis of fMRI studies

(2011) Jeffrey M. Engelmann et al.   NEUROIMAGE

Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects

(2011) Roland R. Griffiths et al.   PSYCHOPHARMACOLOGY

Assessment of addiction severity among ritual users of ayahuasca

(2010) Josep Maria Fábregas et al.   DRUG AND ALCOHOL DEPENDENCE

A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regions

(2010) Anne Lingford-Hughes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Brain stress systems in the amygdala and addiction

(2009) George F. Koob   BRAIN RESEARCH

Brain opioid receptor binding in early abstinence from alcohol dependence and relationship to craving: An [11C]diprenorphine PET study

(2009) Tim M. Williams et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The dopaminergic basis of human behaviors: A review of molecular imaging studies

(2009) Alice Egerton et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Pharmacology of Lysergic Acid Diethylamide: A Review

(2008) Torsten Passie et al.   CNS Neuroscience & Therapeutics

Cortical activation during delay discounting in abstinent methamphetamine dependent individuals

(2008) William F. Hoffman et al.   PSYCHOPHARMACOLOGY