Towards an understanding of psychedelic-induced neuroplasticity

Pharmahuasca and DMT Rescue ROS Production and Differentially Expressed Genes Observed after Predator and Psychosocial Stress: Relevance to Human PTSD

(2022) D. Parker Kelley et al.   ACS Chemical Neuroscience

Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity

(2022) David E. Olson   BIOCHEMISTRY

Therapeutic effect of an ayahuasca analogue in clinically depressed patients: a longitudinal observational study

(2022) Kim van Oorsouw et al.   PSYCHOPHARMACOLOGY

Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participants

(2022) Felix Müller et al.   PSYCHOPHARMACOLOGY

Toward the “helioscope” hypothesis of psychedelic therapy

(2022) Gregor Hasler   EUROPEAN NEUROPSYCHOPHARMACOLOGY

LSD, afterglow and hangover: Increased episodic memory and verbal fluency, decreased cognitive flexibility

(2022) Isabel Wießner et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline

(2022) Danilo De Gregorio et al.   NEUROPSYCHOPHARMACOLOGY

Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects

(2022) Friederike Holze et al.   NEUROPSYCHOPHARMACOLOGY

Ketamine rapidly enhances glutamate-evoked dendritic spinogenesis in medial prefrontal cortex through dopaminergic mechanisms

(2021) Mingzheng Wu et al.   BIOLOGICAL PSYCHIATRY

A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain

(2021) Nakul Ravi Raval et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission

(2021) Danilo De Gregorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Ayahuasca on the Recognition of Facial Expressions of Emotions in Naive Healthy Volunteers

(2021) Juliana Mendes Rocha et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Trial of Psilocybin versus Escitalopram for Depression

(2021) Robin Carhart-Harris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice

(2021) Natalie Hesselgrave et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ayahuasca may help to improve self‐compassion and self‐criticism capacities

(2021) Elisabet Domínguez‐Clavé et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Catalysts for change: the cellular neurobiology of psychedelics

(2021) Matthew I. Banks et al.   MOLECULAR BIOLOGY OF THE CELL

Improving cognitive functioning in major depressive disorder with psychedelics: A dimensional approach

(2021) Igor Magaraggia et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

(2021) Ling-Xiao Shao et al.   NEURON

N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain

(2021) Írisz Szabó et al.   NEUROPHARMACOLOGY

Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics

(2021) Lily R. Aleksandrova et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study in Healthy Subjects

(2021) Anna M. Becker et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Psychedelics for the treatment of depression, anxiety, and existential distress in patients with a terminal illness: a systematic review

(2021) Nina Schimmel et al.   PSYCHOPHARMACOLOGY

Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice

(2021) Mario de la Fuente Revenga et al.   Cell Reports

Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder

(2021) Manoj K. Doss et al.   Translational Psychiatry

The Hallucinogenic Serotonin2A Receptor Agonist, 2,5-Dimethoxy-4-Iodoamphetamine, Promotes cAMP Response Element Binding Protein-Dependent Gene Expression of Specific Plasticity-Associated Genes in the Rodent Neocortex

(2021) Lynette A. Desouza et al.   Frontiers in Molecular Neuroscience

Psychedelics and Psychedelic-Assisted Psychotherapy

(2020) Collin M. Reiff et al.   AMERICAN JOURNAL OF PSYCHIATRY

A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding

(2020) Martin Korsbak Madsen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer

(2020) Gabrielle I Agin-Liebes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions

(2020) Brendan D. Hare et al.   MOLECULAR PSYCHIATRY

Ayahuasca’s ‘afterglow’: improved mindfulness and cognitive flexibility in ayahuasca drinkers

(2020) A Murphy-Beiner et al.   PSYCHOPHARMACOLOGY

Emotions and brain function are altered up to one month after a single high dose of psilocybin

(2020) Frederick S. Barrett et al.   Scientific Reports

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

(2020) N. L. Mason et al.   NEUROPSYCHOPHARMACOLOGY

Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety

(2020) Wei-Zhu Liu et al.   Nature Communications

Psychedelic Treatments for Psychiatric Disorders: A Systematic Review and Thematic Synthesis of Patient Experiences in Qualitative Studies

(2020) Joost J. Breeksema et al.   CNS DRUGS

Sigma-1 (σ1) receptor activity is necessary for physiological brain plasticity in mice

(2020) Lucie Crouzier et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans

(2020) Dea Siggaard Stenbæk et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders

(2020) Franz X. Vollenweider et al.   NATURE REVIEWS NEUROSCIENCE

Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects

(2020) Friederike Holze et al.   NEUROPSYCHOPHARMACOLOGY

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

(2020) Jose A. Morales-Garcia et al.   Translational Psychiatry

A non-hallucinogenic psychedelic analogue with therapeutic potential

(2020) Lindsay P. Cameron et al.   NATURE

Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

(2020) Antonio Inserra et al.   PHARMACOLOGICAL REVIEWS

A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics

(2020) Neil K. Savalia et al.   TRENDS IN NEUROSCIENCES

Platelets Selectively Regulate the Release of BDNF, But Not That of Its Precursor Protein, proBDNF

(2020) Jessica Le Blanc et al.   Frontiers in Immunology

Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder

(2020) Alan K. Davis et al.   JAMA Psychiatry

Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents

(2019) Lindsay P. Cameron et al.   ACS Chemical Neuroscience

Toward specific ways to combine ketamine and psychotherapy in treating depression

(2019) Gregor Hasler   CNS SPECTRUMS

Clinical Therapeutic Strategy and Neuronal Mechanism Underlying Post-Traumatic Stress Disorder (PTSD)

(2019) Yasushi Yabuki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adult neurogenesis in mammals

(2019) Fred H. Gage   SCIENCE

Distinct acute effects of LSD, MDMA, and d-amphetamine in healthy subjects

(2019) Friederike Holze et al.   NEUROPSYCHOPHARMACOLOGY

Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model

(2019) Rebecca B. Price et al.   MOLECULAR PSYCHIATRY

Impaired neuroplasticity in the prefrontal cortex in depression indexed through paired associative stimulation

(2018) Yoshihiro Noda et al.   DEPRESSION AND ANXIETY

A review of plasticity induced by auditory and visual tetanic stimulation in humans

(2018) Philip J. Sanders et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Indexing sensory plasticity: Evidence for distinct Predictive Coding and Hebbian learning mechanisms in the cerebral cortex

(2018) M.J. Spriggs et al.   NEUROIMAGE

Psychedelics Promote Structural and Functional Neural Plasticity

(2018) Calvin Ly et al.   Cell Reports

Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression

(2018) Leor Roseman et al.   Frontiers in Pharmacology

Acute low-dose ketamine produces a rapid and robust increase in plasma BDNF without altering brain BDNF concentrations

(2018) Martin Le Nedelec et al.   Drug Delivery and Translational Research

PET imaging of synaptic density: A new tool for investigation of neuropsychiatric diseases

(2018) Zhengxin Cai et al.   NEUROSCIENCE LETTERS

Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution

(2018) M. V. Uthaug et al.   PSYCHOPHARMACOLOGY

A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus

(2018) Rafael Vitor Lima da Cruz et al.   Frontiers in Molecular Neuroscience

Cerebral plasticity: Windows of opportunity in the developing brain

(2017) Fatima Yousif Ismail et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Assessing the Psychedelic “After-Glow” in Ayahuasca Users: Post-Acute Neurometabolic and Functional Connectivity Changes Are Associated with Enhanced Mindfulness Capacities

(2017) Frederic Sampedro et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Serotonin and brain function: a tale of two receptors

(2017) RL Carhart-Harris et al.   JOURNAL OF PSYCHOPHARMACOLOGY

BDNF at the synapse: why location matters

(2017) M Song et al.   MOLECULAR PSYCHIATRY

The serotonin hallucinogen 5-MeO-DMT alters cortico-thalamic activity in freely moving mice: Regionally-selective involvement of 5-HT 1A and 5-HT 2A receptors

(2017) Maurizio S. Riga et al.   NEUROPHARMACOLOGY

The neural underpinnings of cognitive flexibility and their disruption in psychotic illness

(2017) James A. Waltz   NEUROSCIENCE

Cognitive flexibility in neurological disorders: Cognitive components and event-related potentials

(2017) Florian Lange et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Emotion and the prefrontal cortex: An integrative review.

(2017) Matthew L. Dixon et al.   PSYCHOLOGICAL BULLETIN

Long-lasting subjective effects of LSD in normal subjects

(2017) Yasmin Schmid et al.   PSYCHOPHARMACOLOGY

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

(2017) R. L. Carhart-Harris et al.   PSYCHOPHARMACOLOGY

Modulatory effect of the 5-HT1A agonist buspirone and the mixed non-hallucinogenic 5-HT1A/2A agonist ergotamine on psilocybin-induced psychedelic experience

(2016) Thomas Pokorny et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens

(2016) Anna Rickli et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System

(2016) Vincent Beliveau et al.   JOURNAL OF NEUROSCIENCE

Survey study of challenging experiences after ingesting psilocybin mushrooms: Acute and enduring positive and negative consequences

(2016) Theresa M Carbonaro et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The Challenging Experience Questionnaire: Characterization of challenging experiences with psilocybin mushrooms

(2016) Frederick S Barrett et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

(2016) Roland R Griffiths et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial

(2016) Stephen Ross et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

(2016) L Schmaal et al.   MOLECULAR PSYCHIATRY

The serotonergic hallucinogen 5-methoxy-N,N-dimethyltryptamine disrupts cortical activity in a regionally-selective manner via 5-HT 1A and 5-HT 2A receptors

(2016) Maurizio S. Riga et al.   NEUROPHARMACOLOGY

Long-term follow-up of psilocybin-facilitated smoking cessation

(2016) Matthew W. Johnson et al.   AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE

Cartography of 5-HT1A and 5-HT2A Receptor Subtypes in Prefrontal Cortex and Its Projections

(2015) Guadalupe Mengod et al.   ACS Chemical Neuroscience

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

(2015) Yasmin Schmid et al.   BIOLOGICAL PSYCHIATRY

Peak experiences and the afterglow phenomenon: When and how do therapeutic effects of hallucinogens depend on psychedelic experiences?

(2015) Tomislav Majić et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study

(2015) Michael P Bogenschutz et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs)

(2015) Anna Rickli et al.   NEUROPHARMACOLOGY

State-Dependent Partial Occlusion of Cortical LTP-Like Plasticity in Major Depression

(2015) Marion Kuhn et al.   NEUROPSYCHOPHARMACOLOGY

Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations

(2015) Michael Kometer et al.   PSYCHOPHARMACOLOGY

Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases

(2014) Peter Gasser et al.   JOURNAL OF NERVOUS AND MENTAL DISEASE

LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: A qualitative study of acute and sustained subjective effects

(2014) Peter Gasser et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling

(2014) Tobias Buchborn et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia

(2014) David A. Martin et al.   NEUROPHARMACOLOGY

Rivastigmine improves hippocampal neurogenesis and depression-like behaviors via 5-HT1A receptor stimulation in olfactory bulbectomized mice

(2014) M.R. Islam et al.   NEUROSCIENCE

Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro

(2014) Aaron Janowsky et al.   PSYCHOPHARMACOLOGY

Decreased BDNF and TrkB mRNA expression in multiple cortical areas of patients with schizophrenia and mood disorders

(2014) M T Ray et al.   Translational Psychiatry

The two faces of the pharmacological interaction of mGlu2 and 5-HT2A – Relevance of receptor heterocomplexes and interaction through functional brain pathways

(2013) Hannah K. Delille et al.   NEUROPHARMACOLOGY

PAS-Induced Potentiation of Cortical-Evoked Activity in the Dorsolateral Prefrontal Cortex

(2013) Tarek K Rajji et al.   NEUROPSYCHOPHARMACOLOGY

Neuroplasticity in Depressed Individuals Compared with Healthy Controls

(2013) Michael J Player et al.   NEUROPSYCHOPHARMACOLOGY

Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice

(2013) Shigeki Moriguchi et al.   PLoS One

Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning

(2013) Briony J. Catlow et al.   EXPERIMENTAL BRAIN RESEARCH

Induction of the plasticity-associated immediate early gene Arc by stress and hallucinogens: role of brain-derived neurotrophic factor

(2012) Madhurima Benekareddy et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antidepressant effects of sertraline associated with volume increases in dorsolateral prefrontal cortex

(2012) Ryan Smith et al.   JOURNAL OF AFFECTIVE DISORDERS

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Personality, Psychopathology, Life Attitudes and Neuropsychological Performance among Ritual Users of Ayahuasca: A Longitudinal Study

(2012) José Carlos Bouso et al.   PLoS One

The structural and functional connectivity of the amygdala: From normal emotion to pathological anxiety

(2011) M. Justin Kim et al.   BEHAVIOURAL BRAIN RESEARCH

Harnessing neuroplasticity for clinical applications

(2011) S. C. Cramer et al.   BRAIN

Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists

(2011) José L. Moreno et al.   NEUROSCIENCE LETTERS

Blood BDNF concentrations reflect brain-tissue BDNF levels across species

(2010) Anders B. Klein et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies

(2010) Erich Studerus et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Psychedelics and the Human Receptorome

(2010) Thomas S. Ray   PLoS One

Intrahippocampal LSD accelerates learning and desensitizes the 5-HT2A receptor in the rabbit, Romano et al.

(2010) Anthony G. Romano et al.   PSYCHOPHARMACOLOGY

The partial 5-HT1A receptor agonist buspirone enhances neurogenesis in the opossum (Monodelphis domestica)

(2009) Marta Grabiec et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The glutamate homeostasis hypothesis of addiction

(2009) Peter W. Kalivas   NATURE REVIEWS NEUROSCIENCE

Addiction as a pathology in prefrontal cortical regulation of corticostriatal habit circuitry

(2009) Peter W. Kalivas   NEUROTOXICITY RESEARCH

Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later

(2008) RR Griffiths et al.   JOURNAL OF PSYCHOPHARMACOLOGY

5-HT2A/2C receptor blockade regulates progenitor cell proliferation in the adult rat hippocampus

(2008) Shanker Jha et al.   NEUROSCIENCE LETTERS

Principles of Experience-Dependent Neural Plasticity: Implications for Rehabilitation After Brain Damage

(2008) Jeffrey A. Kleim et al.   JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH