Expression of INPP5D Isoforms in Human Brain: Impact of Alzheimer’s Disease Neuropathology and Genetics

An Alternatively Spliced TREM2 Isoform Lacking the Ligand Binding Domain is Expressed in Human Brain

(2022) Benjamin C. Shaw et al.   JOURNAL OF ALZHEIMERS DISEASE

Allele-specific analysis reveals exon- and cell-type-specific regulatory effects of Alzheimer’s disease-associated genetic variants

(2022) Liang He et al.   Translational Psychiatry

TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

(2022) Shoutang Wang et al.   CELL

Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

(2022) Nimansha Jain et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification and Quantitation of Novel ABI3 Isoforms Relative to Alzheimer’s Disease Genetics and Neuropathology

(2022) Andrew K. Turner et al.   Genes

INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease

(2022) Peter Bor‐Chian Lin et al.   Alzheimers & Dementia

TREM2 dependent and independent functions of microglia in Alzheimer’s disease

(2022) Jinchao Hou et al.   Molecular Neurodegeneration

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

(2021) Seung-Hye Lee et al.   NEURON

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

(2021) Douglas P. Wightman et al.   NATURE GENETICS

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia

(2021) Andy P. Tsai et al.   NEUROBIOLOGY OF DISEASE

Analysis of Genetic Variants Associated with Levels of Immune Modulating Proteins for Impact on Alzheimer’s Disease Risk Reveal a Potential Role for SIGLEC14

(2021) Benjamin C. Shaw et al.   Genes

AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

(2021) Faten A. Sayed et al.   Science Translational Medicine

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

(2020) Maud Gratuze et al.   JOURNAL OF CLINICAL INVESTIGATION

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

(2020) Marta Olah et al.   Nature Communications

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling

(2018) Caixia Li et al.   CELL BIOLOGY INTERNATIONAL

The identity and function of microglia in neurodegeneration

(2018) Wilbur M. Song et al.   NATURE IMMUNOLOGY

INPP5D mRNA Expression and Cognitive Decline in Japanese Alzheimer’s Disease Subjects

(2017) Yuta Yoshino et al.   JOURNAL OF ALZHEIMERS DISEASE

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

(2017) Kuan-lin Huang et al.   NATURE NEUROSCIENCE

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma

(2016) Jisheng Zhang et al.   Cell Death & Disease

LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants: Fig. 1.

(2015) Mitchell J. Machiela et al.   BIOINFORMATICS

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia

(2015) M. Malik et al.   HUMAN MOLECULAR GENETICS

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

(2015) Manasi Malik et al.   Molecular Neurodegeneration

An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform

(2014) Ishita Parikh et al.   Molecular Neurodegeneration

Genetics of PICALM Expression and Alzheimer's Disease

(2014) Ishita Parikh et al.   PLoS One

CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing

(2013) M. Malik et al.   JOURNAL OF NEUROSCIENCE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

The pathogenesis of cingulate atrophy in behavioral variant frontotemporal dementia and Alzheimer’s disease

(2013) Rachel H Tan et al.   Acta Neuropathologica Communications

Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion

(2012) Subhanjan Mondal et al.   MOLECULAR BIOLOGY OF THE CELL

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains

(2012) Celeste M. Karch et al.   PLoS One

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain

(2009) Karrie E Grear et al.   Molecular Neurodegeneration

Mapping the effect of APOE ε4 on gray matter loss in Alzheimer's disease in vivo

(2009) M. Pievani et al.   NEUROIMAGE

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

(2008) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY