An Alternatively Spliced TREM2 Isoform Lacking the Ligand Binding Domain is Expressed in Human Brain

Deletion of Alzheimer's disease‐associated CD33 results in an inflammatory human microglia phenotype

(2021) Jannis Wißfeld et al.   GLIA

The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia

(2021) Abhishek Bhattacherjee et al.   Molecular Neurodegeneration

Alternative Splicing Regulation of Low-Frequency Genetic Variants in Exon 2 of TREM2 in Alzheimer’s Disease by Splicing-Based Aggregation

(2021) Seonggyun Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel TREM2 splicing isoform that lacks the V‐set immunoglobulin domain is abundant in the human brain

(2021) Kostantin Kiianitsa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

(2021) Douglas P. Wightman et al.   NATURE GENETICS

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome

(2021) Katharina Cosker et al.   Scientific Reports

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation

(2020) Michael Ewers et al.   EMBO Molecular Medicine

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

(2020) Maud Gratuze et al.   JOURNAL OF CLINICAL INVESTIGATION

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

(2020) Amanda McQuade et al.   Nature Communications

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

(2019) Li Zhong et al.   Nature Communications

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Evaluation of CD33 as a genetic risk factor for Alzheimer’s disease

(2019) Steven Estus et al.   ACTA NEUROPATHOLOGICA

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

(2019) Jorge L. Del-Aguila et al.   Molecular Neurodegeneration

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

(2019) Ana Griciuc et al.   NEURON

Neurodegenerative Disease–Associated Variants in TREM2 Destabilize the Apical Ligand-Binding Region of the Immunoglobulin Domain

(2019) Hunter B. Dean et al.   Frontiers in Neurology

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia

(2019) Thomas M. Piers et al.   FASEB JOURNAL

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Small nuclear RNA-mediated modulation of splicing reveals a therapeutic strategy for a TREM2 mutation and its post-transcriptional regulation

(2018) Motoaki Yanaizu et al.   Scientific Reports

Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy

(2017) Richard S. Finkel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

(2015) Li Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

FBN1 isoform expression varies in a tissue and development-specific fashion

(2011) Mary E. Burchett et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family

(2010) Y. Numasawa et al.   EUROPEAN JOURNAL OF NEUROLOGY

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling