Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway

The PI3K/AKT Signaling Pathway and Caspase-3 in Alzheimer’s Disease: Which One Is the Beginner?

(2023) Mohammad Rafi Khezri et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of Ferroptosis-Related Genes in Alzheimer’s Disease Based on Bioinformatic Analysis

(2022) Ying Wang et al.   Frontiers in Neuroscience

Integrated Network Pharmacology and Comprehensive Bioinformatics Identifying the Mechanisms and Molecular Targets of Yizhiqingxin Formula for Treatment of Comorbidity With Alzheimer’s Disease and Depression

(2022) Tingting Zhang et al.   Frontiers in Pharmacology

RhoA Signaling in Neurodegenerative Diseases

(2022) Sissel Ida Schmidt et al.   Cells

Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice

(2022) Meng YANG et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends

(2022) Tapan Behl et al.   MOLECULES

Novel therapeutic mechanism of action of metformin and its nanoformulation in Alzheimer's disease and role of AKT/ERK/GSK pathway

(2022) Harish Kumar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease

(2021) Shingo Tsuji et al.   Alzheimers Research & Therapy

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

(2021) Hui-Zhi Long et al.   Frontiers in Pharmacology

Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease

(2021) Chenghui Ye et al.   Cells

The disGeNET cytoscape app: exploring and visualizing disease genomics data

(2021) Janet Piñero et al.   Computational and Structural Biotechnology Journal

Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease

(2021) Zixuan Lin et al.   ANNALS OF NEUROLOGY

Therapeutic Potential of Phytoconstituents in Management of Alzheimer’s Disease

(2021) Anurag Kumar Singh et al.   Evidence-based Complementary and Alternative Medicine

Lipid-Coated MCM-41 Mesoporous Silica Nanoparticles Loaded with Berberine Improved Inhibition of Acetylcholine Esterase and Amyloid Formation

(2021) Anurag Kumar Singh et al.   ACS Biomaterials-Science & Engineering

Functional effects of berberine in modulating mitochondrial dysfunction and inflammatory response in the respective amyloidogenic cells and activated microglial cells – In vitro models simulating Alzheimer's disease pathology

(2021) Ling Rong Wong et al.   LIFE SCIENCES

Therapeutic Potential of Vital Transcription Factors in Alzheimer’s and Parkinson’s Disease With Particular Emphasis on Transcription Factor EB Mediated Autophagy

(2021) Sachchida Nand Rai et al.   Frontiers in Neuroscience

Investigating Neuroprotective Potential of Berberine, Levetiracetam and their Combination in the Management of Alzheimer’s Disease Utilizing Drug Repurposing Strategy

(2021) Suneela Dhaneshwar et al.   Current Reviews in Clinical and Experimental Pharmacology

Berberine ameliorates rats model of combined Alzheimer’s disease and type 2 diabetes mellitus via the suppression of endoplasmic reticulum stress

(2020) Wei-ting Xuan et al.   3 Biotech

Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence

(2020) Xinmei Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Ameliorating Ribosylation-Induced Amyloid-β Pathology by Berberine via Inhibiting mTOR/p70S6K Signaling

(2020) Yang-Yang Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Berberine alleviates amyloid-beta pathogenesis via activating LKB1/AMPK signaling in the brain of APP/PS1 transgenic mice

(2019) Zhi-You Cai et al.   CURRENT MOLECULAR MEDICINE

Rhizoma Coptidis for Alzheimer’s Disease and Vascular Dementia: A Literature Review

(2019) Zhiyong Wang et al.   Current Vascular Pharmacology

Role of TREM2 in Alzheimer's disease and its consequences on β-amyloid, Tau and neurofibrillary tangles

(2019) Anurag Kumar Singh et al.   Current Alzheimer Research

Editorial: The Alzheimer's Disease Challenge

(2019) Athanasios Alexiou et al.   Frontiers in Neuroscience

Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline

(2019) Matteo Spinelli et al.   Frontiers in Neuroscience

The DisGeNET knowledge platform for disease genomics: 2019 update

(2019) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

Targeting Fyn Kinase in Alzheimer’s Disease

(2018) Haakon B. Nygaard   BIOLOGICAL PSYCHIATRY

Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities

(2018) Valentina Zamboni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intracellular amyloid beta expression leads to dysregulation of the mitogen-activated protein kinase and bone morphogenetic protein-2 signaling axis

(2018) Eric Cruz et al.   PLoS One

Coptidis rhizoma and its main bioactive components: recent advances in chemical investigation, quality evaluation and pharmacological activity

(2018) Fan-Cheng Meng et al.   Chinese Medicine

BDNF, TNFα, HSP90, CFH, and IL-10 Serum Levels in Patients with Early or Late Onset Alzheimer's Disease or Mild Cognitive Impairment

(2018) Duygu Gezen-Ak et al.   JOURNAL OF ALZHEIMERS DISEASE

AKT phosphorylation sites of Ser473 and Thr308 regulate AKT degradation

(2018) Yingze Wei et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database

(2017) Xia Wang et al.   NUCLEIC ACIDS RESEARCH

Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation

(2017) Wenbo He et al.   Pharmacological Reports

DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants

(2016) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

Current knowledge and pharmacological profile of berberine: An update

(2015) Anil Kumar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Therapeutic potential of berberine against neurodegenerative diseases

(2015) WenXiao Jiang et al.   Science China-Life Sciences

Ganetespib: research and clinical development

(2015) Shanu Modi et al.   OncoTargets and Therapy

DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes

(2015) J. Pinero et al.   Database-The Journal of Biological Databases and Curation

Targeting Hsp90 and its co-chaperones to treat Alzheimer’s disease

(2014) Laura J Blair et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Preparative separation of quaternary ammonium alkaloids from Coptis chinensis Franch by pH-zone-refining counter-current chromatography

(2014) Changlei Sun et al.   JOURNAL OF CHROMATOGRAPHY A

Hsp90 Chaperone Inhibitor 17-AAG Attenuates A -Induced Synaptic Toxicity and Memory Impairment

(2014) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Interactions between Amyloid-β and Tau Fragments Promote Aberrant Aggregates: Implications for Amyloid Toxicity

(2014) Thanh D. Do et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway

(2014) Meihui Chen et al.   METABOLIC BRAIN DISEASE

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

(2014) Jinlong Ru et al.   Journal of Cheminformatics

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease

(2014) Yasuko Kitagishi et al.   Alzheimers Research & Therapy

Heat Shock Protein 90 in Alzheimer’s Disease

(2014) Jiang-Rong Ou et al.   Biomed Research International

Experimental research Effects of berberine on β-secretase activity in a rabbit model of Alzheimer’s disease

(2013) Negar Panahi et al.   Archives of Medical Science

A Novel Chemometric Method for the Prediction of Human Oral Bioavailability

(2012) Xue Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease

(2012) Weiyang Tao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

(2012) Siva Sundara Kumar Durairajan et al.   NEUROBIOLOGY OF AGING

Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: Involvement of NF-κB signaling pathway

(2010) Qin Jiang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Caspases first

(2010) Jesús Avila   Nature Reviews Neurology

Neural Markers Espression in Rat Bone Marrow Mesenchymal Stem Cell Cultures Treated with Neurosteroids

(2010) Daniela Bronzi et al.   NEUROCHEMICAL RESEARCH

PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach

(2010) Xiaofeng Liu et al.   NUCLEIC ACIDS RESEARCH

Network analyses in systems pharmacology

(2009) S. I. Berger et al.   BIOINFORMATICS

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY