Therapeutic Potential of Phytoconstituents in Management of Alzheimer’s Disease

Neuroprotective and Neurorescue Mode of Action of Bacopa monnieri (L.) Wettst in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson’s Disease: An In Silico and In Vivo Study

(2021) Babita Singh et al.   Frontiers in Pharmacology

5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer’s disease

(2020) Fang Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

Protective effect of surface-modified berberine nanoparticles against LPS-induced neurodegenerative changes: a preclinical study

(2019) Salma A. Soudi et al.   Drug Delivery and Translational Research

Biological Evaluation and Docking Analysis of Potent BACE1 Inhibitors from Boesenbergia rotunda

(2019) Kumju Youn et al.   Nutrients

Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model

(2019) Amanda Cano et al.   JOURNAL OF CONTROLLED RELEASE

Role of TREM2 in Alzheimer's disease and its consequences on β-amyloid, Tau and neurofibrillary tangles

(2019) Anurag Kumar Singh et al.   Current Alzheimer Research

Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus

(2019) Carolina B. Lindsay et al.   MOLECULAR NEUROBIOLOGY

Danshen (Salvia miltiorrhiza Bunge): A Prospective Healing Sage for Cardiovascular Diseases

(2018) Wei Chen et al.   CURRENT PHARMACEUTICAL DESIGN

Cerebrospinal Fluid and Plasma Levels of Inflammation Differentially Relate to CNS Markers of Alzheimer’s Disease Pathology and Neuronal Damage

(2018) Brianne M. Bettcher et al.   JOURNAL OF ALZHEIMERS DISEASE

Use of functionalized liposomes loaded with antioxidants to permeate the blood–brain barrier and inhibit β-amyloid-induced neurodegeneration in the brain

(2018) Yung-Chih Kuo et al.   Journal of the Taiwan Institute of Chemical Engineers

New views and possibilities of antidiabetic drugs in treating and/or preventing mild cognitive impairment and Alzheimer’s Disease

(2018) Kai Long Zhong et al.   METABOLIC BRAIN DISEASE

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

(2018) Cyril Laurent et al.   Biomedical Journal

Oral Brain-Targeted Microemulsion for Enhanced Piperine Delivery in Alzheimer’s Disease Therapy: In Vitro Appraisal, In Vivo Activity, and Nanotoxicity

(2018) Samar M. Etman et al.   AAPS PHARMSCITECH

Tau Oligomers and Fibrils Induce Activation of Microglial Cells

(2018) Inelia Morales et al.   JOURNAL OF ALZHEIMERS DISEASE

AβPP-Selective BACE Inhibitors (ASBI): Novel Class of Therapeutic Agents for Alzheimer's Disease

(2018) Olivier Descamps et al.   JOURNAL OF ALZHEIMERS DISEASE

Design of epigallocatechin gallate loaded PLGA/PF127 nanoparticles and their effect upon an oxidative stress model

(2018) Gina P. Hoyos-Ceballos et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Self-Assembled Curcumin–Poly(carboxybetaine methacrylate) Conjugates: Potent Nano-Inhibitors against Amyloid β-Protein Fibrillogenesis and Cytotoxicity

(2018) Guangfu Zhao et al.   LANGMUIR

EGCG Nanoparticles Attenuate Aluminum Chloride Induced Neurobehavioral Deficits, Beta Amyloid and Tau Pathology in a Rat Model of Alzheimer’s Disease

(2018) Neha Atulkumar Singh et al.   Frontiers in Aging Neuroscience

Brain Delivery of Curcumin Using Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Preparation, Optimization, and Pharmacokinetic Evaluation

(2018) Soroor Sadegh Malvajerd et al.   ACS Chemical Neuroscience

Progressive release of mesoporous nano-selenium delivery system for the multi-channel synergistic treatment of Alzheimer's disease

(2018) Jing Sun et al.   BIOMATERIALS

A novel synthesis of selenium nanoparticles encapsulated PLGA nanospheres with curcumin molecules for the inhibition of amyloid β aggregation in Alzheimer's disease

(2018) Xinlong Huo et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Anti-Alzheimer's potential of berberine using surface decorated multi-walled carbon nanotubes: A preclinical evidence

(2017) Shikha Lohan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Dysregulated Metabolism of the Amyloid-β Protein and Therapeutic Approaches in Alzheimer Disease

(2017) Kazunori Kikuchi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mucuna pruriens reduces inducible nitric oxide synthase expression in Parkinsonian mice model

(2017) Satyndra Kumar Yadav et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Immunomodulation of Parkinson’s disease using Mucuna pruriens (Mp)

(2017) Sachchida Nand Rai et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Neuroprotective effect of curcumin-I in copper-induced dopaminergic neurotoxicity in rats: A possible link with Parkinson’s disease

(2017) Abdellatif Abbaoui et al.   NEUROSCIENCE LETTERS

CysLT1R downregulation reverses intracerebroventricular streptozotocin-induced memory impairment via modulation of neuroinflammation in mice

(2017) Arijit Ghosh et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression

(2017) Shirley James et al.   Scientific Reports

Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson’s Disease through NF-κB/pAKT Signaling Pathways

(2017) Sachchida N. Rai et al.   Frontiers in Aging Neuroscience

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer’s disease

(2016) Xun-Hu Gu et al.   BEHAVIOURAL BRAIN RESEARCH

Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells

(2016) Guoqiong Cao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Promises of a biocompatible nanocarrier in improved brain delivery of quercetin: Biochemical, pharmacokinetic and biodistribution evidences

(2016) Pramod Kumar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

Neurofibrillary tangles in Alzheimer′s disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics

(2016) StefanJ Kempf et al.   Neural Regeneration Research

Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease

(2016) Matin Ramezani et al.   Neural Regeneration Research

Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus)

(2016) Daniela S. Rivera et al.   NEUROBIOLOGY OF AGING

Asperterpenes A and B, two unprecedented meroterpenoids from Aspergillus terreus with BACE1 inhibitory activities

(2016) Changxing Qi et al.   Chemical Science

Salvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells

(2016) Ying Tang et al.   Nutrients

Role of RAGE in Alzheimer’s Disease

(2015) Zhiyou Cai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease

(2015) Fanfei Meng et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Novel piperine-loaded Tween-integrated monoolein cubosomes as brain-targeted oral nanomedicine in Alzheimer’s disease: pharmaceutical, biological, and toxicological studies

(2015) Yosra Elnaggar et al.   International Journal of Nanomedicine

Genistein Alleviatesβ-Amyloid-Induced Inflammatory Damage Through Regulating Toll-Like Receptor 4/Nuclear FactorκB

(2015) Weiwei Ma et al.   JOURNAL OF MEDICINAL FOOD

Silibinin Prevents Autophagic Cell Death upon Oxidative Stress in Cortical Neurons and Cerebral Ischemia-Reperfusion Injury

(2015) Min Wang et al.   MOLECULAR NEUROBIOLOGY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice

(2015) Felipe G Serrano et al.   Molecular Neurodegeneration

Epigallocatechin-3-gallate (EGCG)-Stabilized Selenium Nanoparticles Coated with Tet-1 Peptide To Reduce Amyloid-β Aggregation and Cytotoxicity

(2014) Jingnan Zhang et al.   ACS Applied Materials & Interfaces

Multifunctional nanoliposomes with curcumin–lipid derivative and brain targeting functionality with potential applications for Alzheimer disease

(2014) Spyridon Mourtas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Withania somnifera Alleviates Parkinsonian Phenotypes by Inhibiting Apoptotic Pathways in Dopaminergic Neurons

(2014) Jay Prakash et al.   NEUROCHEMICAL RESEARCH

Promoting Autophagic Clearance: Viable Therapeutic Targets in Alzheimer’s Disease

(2014) Lauren G. Friedman et al.   Neurotherapeutics

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

(2014) Inelia Morales et al.   Frontiers in Cellular Neuroscience

Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model via Canonical Wnt/β-Catenin Pathway

(2013) Shashi Kant Tiwari et al.   ACS Nano

Lipid-Core Nanocapsules Improve the Effects of Resveratrol Against Aβ-Induced Neuroinflammation

(2013) Rudimar L. Frozza et al.   Journal of Biomedical Nanotechnology

Neuroprotective Effects of Resveratrol Against Aβ Administration in Rats are Improved by Lipid-Core Nanocapsules

(2013) Rudimar L. Frozza et al.   MOLECULAR NEUROBIOLOGY

Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: Involvement of BDNF and Akt/GSK-3β signaling pathway

(2013) Juliana B. Hoppe et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Ferulic Acid Is a Nutraceutical β-Secretase Modulator That Improves Behavioral Impairment and Alzheimer-like Pathology in Transgenic Mice

(2013) Takashi Mori et al.   PLoS One

Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

(2012) Kwok Kin Cheng et al.   AAPS Journal

The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders II: Alzheimers Disease

(2012) Miguel Divino da Rocha et al.   CNS & Neurological Disorders-Drug Targets

Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer’s disease models

(2012) Andressa Bernardi et al.   International Journal of Nanomedicine

Tannic Acid Is a Natural β-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice

(2012) Takashi Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preparation, characterization,in vivoand biochemical evaluation of brain targeted Piperine solid lipid nanoparticles in an experimentally induced Alzheimer’s disease model

(2012) Mohammad Yusuf et al.   JOURNAL OF DRUG TARGETING

Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: A randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg

(2012) Horst Herrschaft et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Curcumin Loaded-PLGA Nanoparticles Conjugated with Tet-1 Peptide for Potential Use in Alzheimer's Disease

(2012) Anila Mathew et al.   PLoS One

Effects of Panax ginseng in Neurodegenerative Diseases

(2012) Ik-Hyun Cho   Journal of Ginseng Research

Biflavonoids Are Superior to Monoflavonoids in Inhibiting Amyloid-β Toxicity and Fibrillogenesis via Accumulation of Nontoxic Oligomer-like Structures

(2011) Arjun Thapa et al.   BIOCHEMISTRY

Neuroprotective effects of linarin through activation of the PI3K/Akt pathway in amyloid-β-induced neuronal cell death

(2011) Haiyan Lou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Baicalein Inhibits Formation of α-Synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerisation

(2011) Jia-Hong Lu et al.   CHEMBIOCHEM

Phytochemical Composition, Antioxidant Activity, and Neuroprotective Effect ofTerminalia chebulaRetzius Extracts

(2011) Chia Lin Chang et al.   Evidence-based Complementary and Alternative Medicine

Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain

(2011) Vandita Kakkar et al.   FOOD AND CHEMICAL TOXICOLOGY

Piperine as an adjuvant increases the efficacy of curcumin in mitigating benzo(a)pyrene toxicity

(2011) A Sehgal et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery

(2011) Sanju Dhawan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Chitosan enhances the stability and targeting of immuno-nanovehicles to cerebro-vascular deposits of Alzheimer's disease amyloid protein

(2011) Kristen M. Jaruszewski et al.   Nanomedicine-Nanotechnology Biology and Medicine

A phase II trial of huperzine A in mild to moderate Alzheimer disease

(2011) M. S. Rafii et al.   NEUROLOGY

Nootropic, anxiolytic and CNS-depressant studies on different plant sources ofshankhpushpi

(2011) Jai Malik et al.   PHARMACEUTICAL BIOLOGY

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Identification of serotonin 5-HT1A receptor partial agonists in ginger

(2010) Andreas Nievergelt et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nanolipidic particles improve the bioavailability and α-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease

(2010) Adam Smith et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

2,2′,4′-Trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice

(2010) Zhiyuan Zhu et al.   JOURNAL OF NEUROCHEMISTRY

Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity

(2010) Jun Lu et al.   JOURNAL OF PATHOLOGY

ApoE3 Mediated Poly(butyl) Cyanoacrylate Nanoparticles Containing Curcumin: Study of Enhanced Activity of Curcumin against Beta Amyloid Induced Cytotoxicity UsingIn VitroCell Culture Model

(2010) Rohit S. Mulik et al.   MOLECULAR PHARMACEUTICS

Nootropic activity ofCelastrus paniculatusseed

(2010) M. Bhanumathy et al.   PHARMACEUTICAL BIOLOGY

Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38

(2009) Soraya L. Vallés et al.   AGING CELL

The effect of curcumin (turmeric) onAlzheimer′s disease: An overview

(2009) Shrikant Mishra et al.   Annals of Indian Academy of Neurology

The role of antioxidant properties of Nardostachys jatamansi in alleviation of the symptoms of the chronic fatigue syndrome

(2009) Nazmun Lyle et al.   BEHAVIOURAL BRAIN RESEARCH

Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids

(2009) Hyun Ah Jung et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes

(2009) Soraya L. Valles et al.   BRAIN RESEARCH

A Systematic Review of Single Chinese Herbs for Alzheimer's Disease Treatment

(2009) Li-Min Fu et al.   Evidence-based Complementary and Alternative Medicine

Resveratrol-loaded polymeric micelles protect cells from Aβ-induced oxidative stress

(2009) Xiaowei Lu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model

(2009) Nongnut Uabundit et al.   JOURNAL OF ETHNOPHARMACOLOGY

Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer’s disease: an updated meta-analysis

(2009) Bai-song Wang et al.   JOURNAL OF NEURAL TRANSMISSION

Biological actions of curcumin on articular chondrocytes

(2009) Y. Henrotin et al.   OSTEOARTHRITIS AND CARTILAGE

Withanamides inWithania somniferafruit protect PC-12 cells from β-amyloid responsible for Alzheimer's disease

(2009) Bolleddula Jayaprakasam et al.   PHYTOTHERAPY RESEARCH

Chemical Constituents of Terminalia chebula

(2009) Z Ali et al.   PLANTA MEDICA

1,2,3,4,6-penta-O-galloyl-β-d-glucose: A cholinesterase inhibitor from Terminalia chebula

(2009) S. Sancheti et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Quinoline-n -butylcyanoacrylate-based nanoparticles for brain targeting for the diagnosis of Alzheimer's disease

(2009) Padmakar V. Kulkarni et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Flavonols and flavones as BACE-1 inhibitors: Structure–activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features

(2008) Yoshiari Shimmyo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging

(2008) Ram Harsh Singh et al.   BIOGERONTOLOGY

Therapeutic Potential of γ -Secretase Inhibitors and Modulators

(2008) Bruno Imbimbo   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Ayurvedic medicine Clitoria ternatea—From traditional use to scientific assessment

(2008) Pulok K. Mukherjee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease

(2008) A. N. Begum et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Anxiety and cognitive effects of quercetin liposomes in rats

(2008) Aroonsri Priprem et al.   Nanomedicine-Nanotechnology Biology and Medicine

Effect ofConvulvulus pluricaulisChoisy. on learning behaviour and memory enhancement activity in rodents

(2008) Alok Nahata et al.   NATURAL PRODUCT RESEARCH

Examining the nootropic effects of a special extract ofBacopa monnieraon human cognitive functioning: 90 day double-blind placebo-controlled randomized trial

(2008) Con Stough et al.   PHYTOTHERAPY RESEARCH

Centella asiaticaextract selectively decreases amyloidβlevels in hippocampus of Alzheimer's disease animal model

(2008) Muralikrishnan Dhanasekaran et al.   PHYTOTHERAPY RESEARCH

Multifunction of myricetin on Aβ: Neuroprotection via a conformational change of Aβ and reduction of Aβ via the interference of secretases

(2007) Yoshiari Shimmyo et al.   JOURNAL OF NEUROSCIENCE RESEARCH