Mitochondrial network structure controls cell-to-cell mtDNA variability generated by cell divisions

Concentration fluctuations in growing and dividing cells: Insights into the emergence of concentration homeostasis

(2022) Chen Jia et al.   PLoS Computational Biology

Stochastic survival of the densest and mitochondrial DNA clonal expansion in aging

(2022) Ferdinando Insalata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin cables and comet tails organize mitochondrial networks in mitosis

(2021) Andrew S. Moore et al.   NATURE

Cell size distribution of lineage data: analytic results and parameter inference

(2021) Chen Jia et al.   iScience

Frequency Domain Analysis of Fluctuations of mRNA and Protein Copy Numbers within a Cell Lineage: Theory and Experimental Validation

(2021) Chen Jia et al.   Physical Review X

Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck

(2021) David M. Edwards et al.   PLOS BIOLOGY

Network analysis of Arabidopsis mitochondrial dynamics reveals a resolved tradeoff between physical distribution and social connectivity

(2021) Joanna M. Chustecki et al.   Cell Systems

Cristae-dependent quality control of the mitochondrial genome

(2021) Christopher Jakubke et al.   Science Advances

A new automated tool to quantify nucleoid distribution within mitochondrial networks

(2021) Hema Saranya Ilamathi et al.   Scientific Reports

Membrane and organelle dynamics during cell division

(2020) Jeremy G. Carlton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Inheritance in Phytopathogenic Fungi—Everything Is Known, or Is It?

(2020) Hector Mendoza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Maintenance of Mitochondrial DNA Integrity and Dynamics by Mitochondrial Membranes

(2020) James Chapman et al.   Life-Basel

Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline

(2019) Toby Lieber et al.   NATURE

Germline selection shapes human mitochondrial DNA diversity

(2019) Wei Wei et al.   SCIENCE

Mitochondrial Network State Scales mtDNA Genetic Dynamics

(2019) Juvid Aryaman et al.   GENETICS

Reshaping membranes to build mitochondrial DNA

(2019) David Pla-Martin et al.   PLoS Genetics

Varied Mechanisms and Models for the Varying Mitochondrial Bottleneck

(2019) Iain G. Johnston   Frontiers in Cell and Developmental Biology

3D super-resolution microscopy reflects mitochondrial cristae alternations and mtDNA nucleoid size and distribution

(2018) Andrea Dlasková et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Spatial Stochastic Intracellular Kinetics: A Review of Modelling Approaches

(2018) Stephen Smith et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Mitochondrial DNA Heteroplasmy and Purifying Selection in the Mammalian Female Germ Line

(2018) Stephen P. Burr et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos

(2018) Vasileios I. Floros et al.   NATURE CELL BIOLOGY

Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations

(2018) Joerg P. Burgstaller et al.   Nature Communications

Mitochondrial network complexity emerges from fission/fusion dynamics

(2018) Nahuel Zamponi et al.   Scientific Reports

Tension and Resolution: Dynamic, Evolving Populations of Organelle Genomes within Plant Cells

(2018) Iain G. Johnston   Molecular Plant

Sources, propagation and consequences of stochasticity in cellular growth

(2018) Philipp Thomas et al.   Nature Communications

Mitigating Mitochondrial Genome Erosion Without Recombination

(2017) Arunas L. Radzvilavicius et al.   GENETICS

The CoRR hypothesis for genes in organelles

(2017) John F. Allen   JOURNAL OF THEORETICAL BIOLOGY

Mitigating Mitochondrial Genome Erosion Without Recombination

(2017) Arunas L. Radzvilavicius et al.   GENETICS

Live imaging reveals the dynamics and regulation of mitochondrial nucleoids during the cell cycle in Fucci2-HeLa cells

(2017) Taeko Sasaki et al.   Scientific Reports

Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations

(2016) Iain G. Johnston et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Accurate concentration control of mitochondria and nucleoids

(2016) R. Jajoo et al.   SCIENCE

Evolutionary Inference across Eukaryotes Identifies Specific Pressures Favoring Mitochondrial Gene Retention

(2016) Iain G. Johnston et al.   Cell Systems

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research

(2015) Hanne Hoitzing et al.   BIOESSAYS

Comparison of different moment-closure approximations for stochastic chemical kinetics

(2015) David Schnoerr et al.   JOURNAL OF CHEMICAL PHYSICS

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Mitochondrial and plastid genome architecture: Reoccurring themes, but significant differences at the extremes

(2015) David Roy Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Closed-form stochastic solutions for non-equilibrium dynamics and inheritance of cellular components over many cell divisions

(2015) Iain G. Johnston et al.   PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations

(2015) Zhi Yang Tam et al.   PLoS Computational Biology

Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

(2015) Iain G Johnston et al.   eLife

Why are most organelle genomes transmitted maternally?

(2014) Stephan Greiner et al.   BIOESSAYS

Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant

(2014) Jahda H Hill et al.   NATURE GENETICS

mtDNA Segregation in Heteroplasmic Tissues Is Common In Vivo and Modulated by Haplotype Differences and Developmental Stage

(2014) Joerg Patrick Burgstaller et al.   Cell Reports

Mathematical Modeling of the Role of Mitochondrial Fusion and Fission in Mitochondrial DNA Maintenance

(2013) Zhi Yang Tam et al.   PLoS One

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Optimal Dynamics for Quality Control in Spatially Distributed Mitochondrial Networks

(2013) Pinkesh K. Patel et al.   PLoS Computational Biology

Emergence of the Mitochondrial Reticulum from Fission and Fusion Dynamics

(2012) Valerii M. Sukhorukov et al.   PLoS Computational Biology

Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging

(2012) Marc Thilo Figge et al.   PLoS Computational Biology

Mitochondrial Variability as a Source of Extrinsic Cellular Noise

(2012) Iain G. Johnston et al.   PLoS Computational Biology

Non-genetic heterogeneity from stochastic partitioning at cell division

(2010) Dann Huh et al.   NATURE GENETICS

Frequency and Selectivity of Mitochondrial Fusion Are Key to Its Quality Maintenance Function

(2009) Pradeep K. Mouli et al.   BIOPHYSICAL JOURNAL

New Evidence Confirms That the Mitochondrial Bottleneck Is Generated without Reduction of Mitochondrial DNA Content in Early Primordial Germ Cells of Mice

(2009) Liqin Cao et al.   PLoS Genetics

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

(2008) Gilad Twig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Quantifying Origins of Cell-to-Cell Variations in Gene Expression

(2008) Julia Rausenberger et al.   BIOPHYSICAL JOURNAL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

(2008) Timothy Wai et al.   NATURE GENETICS

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

(2008) Lynsey M Cree et al.   NATURE GENETICS

A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

(2008) Weiwei Fan et al.   SCIENCE

Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA

(2008) James Bruce Stewart et al.   PLOS BIOLOGY