Varied Mechanisms and Models for the Varying Mitochondrial Bottleneck

Germline selection shapes human mitochondrial DNA diversity

(2019) Wei Wei et al.   SCIENCE

Mitochondrial Network State Scales mtDNA Genetic Dynamics

(2019) Juvid Aryaman et al.   GENETICS

Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations

(2019) Hanne Hoitzing et al.   PLoS Computational Biology

Evolving mtDNA populations within cells

(2019) Iain G. Johnston et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy

(2019) Ana Latorre-Pellicer et al.   Cell Metabolism

The mitochondrial DNA genetic bottleneck: inheritance and beyond

(2018) Haixin Zhang et al.   Essays in Biochemistry

A Population Phylogenetic View of Mitochondrial Heteroplasmy

(2018) Peter R. Wilton et al.   GENETICS

Mutation-specific effects in germline transmission of pathogenic mtDNA variants

(2018) Auke B C Otten et al.   HUMAN REPRODUCTION

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos

(2018) Vasileios I. Floros et al.   NATURE CELL BIOLOGY

Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations

(2018) Joerg P. Burgstaller et al.   Nature Communications

A Population Phylogenetic View of Mitochondrial Heteroplasmy

(2018) Peter R. Wilton et al.   GENETICS

Tension and Resolution: Dynamic, Evolving Populations of Organelle Genomes within Plant Cells

(2018) Iain G. Johnston   Molecular Plant

Mitochondrial genetic medicine

(2018) Douglas C. Wallace   NATURE GENETICS

Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations

(2016) Iain G. Johnston et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

(2016) Mingkun Li et al.   GENOME RESEARCH

Mitochondrial DNA sequence characteristics modulate the size of the genetic bottleneck

(2016) Ian J. Wilson et al.   HUMAN MOLECULAR GENETICS

Mitophagy plays a central role in mitochondrial ageing

(2016) Alan Diot et al.   MAMMALIAN GENOME

Accurate concentration control of mitochondria and nucleoids

(2016) R. Jajoo et al.   SCIENCE

Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells

(2016) Auke B.C. Otten et al.   Cell Reports

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research

(2015) Hanne Hoitzing et al.   BIOESSAYS

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Closed-form stochastic solutions for non-equilibrium dynamics and inheritance of cellular components over many cell divisions

(2015) Iain G. Johnston et al.   PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

(2015) Iain G Johnston et al.   eLife

Mitochondrial DNA disease and developmental implications for reproductive strategies

(2014) Joerg Patrick Burgstaller et al.   MOLECULAR HUMAN REPRODUCTION

A Wide Range of 3243A>G/tRNALeu(UUR) (MELAS) Mutation Loads May Segregate in Offspring through the Female Germline Bottleneck

(2014) Francesco Pallotti et al.   PLoS One

Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA

(2014) B. Rebolledo-Jaramillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model selection in systems and synthetic biology

(2013) Paul Kirk et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mutation dependance of the mitochondrial DNA copy number in the first stages of human embryogenesis

(2013) Sophie Monnot et al.   HUMAN MOLECULAR GENETICS

Very Low-Level Heteroplasmy mtDNA Variations Are Inherited in Humans

(2013) Yan Guo et al.   Journal of Genetics and Genomics

Preimplantation genetic diagnosis in mitochondrial DNA disorders: challenge and success

(2013) Suzanne C E H Sallevelt et al.   JOURNAL OF MEDICAL GENETICS

The activity and copy number of mitochondrial DNA in ovine oocytes throughout oogenesis in vivo and during oocyte maturation in vitro

(2013) Matthew Cotterill et al.   MOLECULAR HUMAN REPRODUCTION

Mathematical Modeling of the Role of Mitochondrial Fusion and Fission in Mitochondrial DNA Maintenance

(2013) Zhi Yang Tam et al.   PLoS One

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Insight into mammalian mitochondrial DNA segregation

(2012) Riikka Jokinen et al.   ANNALS OF MEDICINE

Blastocyst preimplantation genetic diagnosis (PGD) of a mitochondrial DNA disorder

(2012) Nathan R. Treff et al.   FERTILITY AND STERILITY

Rapid Mitochondrial DNA Segregation in Primate Preimplantation Embryos Precedes Somatic and Germline Bottleneck

(2012) Hyo-Sang Lee et al.   Cell Reports

Mitochondrial Variability as a Source of Extrinsic Cellular Noise

(2012) Iain G. Johnston et al.   PLoS Computational Biology

Neutral mitochondrial heteroplasmy and the influence of aging

(2011) Neal Sondheimer et al.   HUMAN MOLECULAR GENETICS

The implications of mitochondrial DNA copy number regulation during embryogenesis

(2011) Phillippa J. Carling et al.   MITOCHONDRION

The Strength and Timing of the Mitochondrial Bottleneck in Salmon Suggests a Conserved Mechanism in Vertebrates

(2011) Jonci N. Wolff et al.   PLoS One

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA

(2011) C. Kukat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Previous Estimates of Mitochondrial DNA Mutation Level Variance Did Not Account for Sampling Error: Comparing the mtDNA Genetic Bottleneck in Mice and Humans

(2010) Passorn Wonnapinij et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model system

(2010) Sophie Monnot et al.   HUMAN MUTATION

Reassessing evidence for a postnatal mitochondrial genetic bottleneck

(2010) David C Samuels et al.   NATURE GENETICS

Non-genetic heterogeneity from stochastic partitioning at cell division

(2010) Dann Huh et al.   NATURE GENETICS

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modelling mitochondrial site polymorphisms to infer the number of segregating units and mutation rate

(2009) M. D. Hendy et al.   Biology Letters

New Evidence Confirms That the Mitochondrial Bottleneck Is Generated without Reduction of Mitochondrial DNA Content in Early Primordial Germ Cells of Mice

(2009) Liqin Cao et al.   PLoS Genetics

The Distribution of Mitochondrial DNA Heteroplasmy Due to Random Genetic Drift

(2008) Passorn Wonnapinij et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Two ways to make an mtDNA bottleneck

(2008) Konstantin Khrapko   NATURE GENETICS

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

(2008) Timothy Wai et al.   NATURE GENETICS

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

(2008) Lynsey M Cree et al.   NATURE GENETICS

A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

(2008) Weiwei Fan et al.   SCIENCE

Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic

(2008) Craig D. Millar et al.   PLoS Genetics