High-resolution structural-omics of human liver enzymes

Approaches to Using the Chameleon: Robust, Automated, Fast-Plunge cryoEM Specimen Preparation

(2022) Talya S. Levitz et al.   Frontiers in Molecular Biosciences

A ‘Build and Retrieve’ methodology to simultaneously solve cryo-EM structures of membrane proteins

(2021) Chih-Chia Su et al.   NATURE METHODS

SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling

(2021) Nathaniel J. Robinson et al.   Science Signaling

Cryo-EM structures from sub-nl volumes using pin-printing and jet vitrification

(2020) Raimond B. G. Ravelli et al.   Nature Communications

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

(2020) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM

(2019) Mark A. Herzik et al.   Nature Communications

The crystal structure of human microsomal triglyceride transfer protein

(2019) Ekaterina I. Biterova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Separating distinct structures of multiple macromolecular assemblies from cryo-EM projections

(2019) Eric J. Verbeke et al.   JOURNAL OF STRUCTURAL BIOLOGY

Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu

(2019) Chi-Min Ho et al.   NATURE METHODS

Approaches to altering particle distributions in cryo-electron microscopy sample preparation

(2018) Ieva Drulyte et al.   Acta Crystallographica Section D-Structural Biology

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Blotting-free and lossless cryo-electron microscopy grid preparation from nanoliter-sized protein samples and single-cell extracts

(2017) Stefan A. Arnold et al.   JOURNAL OF STRUCTURAL BIOLOGY

Capturing protein communities by structural proteomics in a thermophilic eukaryote

(2017) Panagiotis L Kastritis et al.   Molecular Systems Biology

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Addressing preferred specimen orientation in single-particle cryo-EM through tilting

(2017) Yong Zi Tan et al.   NATURE METHODS

Mutations in GANAB , Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease

(2016) Binu Porath et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals

(2016) Alessandro T. Caputo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single particle electron cryomicroscopy: trends, issues and future perspective

(2016) Kutti R. Vinothkumar et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1

(2015) Cynthia A. Morgan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase

(2015) Catarina Coelho et al.   Nature Chemical Biology

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

(2013) Markku Varjosalo et al.   NATURE METHODS

The First Mammalian Aldehyde Oxidase Crystal Structure

(2012) Catarina Coelho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome

(2012) Young-Ki Paik et al.   NATURE BIOTECHNOLOGY

Crystal Structure of Reduced and of Oxidized Peroxiredoxin IV Enzyme Reveals a Stable Oxidized Decamer and a Non-disulfide-bonded Intermediate in the Catalytic Cycle

(2011) Zhenbo Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

Liver Anatomy

(2010) Sherif R. Z. Abdel-Misih et al.   SURGICAL CLINICS OF NORTH AMERICA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

ERp46 is reduced by high glucose and regulates insulin content in pancreatic β-cells

(2009) Avra Alberti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glycoproteomics Analysis of Human Liver Tissue by Combination of Multiple Enzyme Digestion and Hydrazide Chemistry

(2009) Rui Chen et al.   JOURNAL OF PROTEOME RESEARCH

Molecular Recognition of the Protein Phosphatase 1 Glycogen Targeting Subunit by Glycogen Phosphorylase

(2008) Alexander Pautsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency

(2008) Gareth G. Lavery et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY