SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling

Histone Modifications and the Maintenance of Telomere Integrity

(2019) Meagan Jezek et al.   Cells

Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways

(2019) Jia-Min Zhang et al.   Cell Reports

RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening

(2019) Priyanka Verma et al.   GENES & DEVELOPMENT

CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing

(2019) Kornel Labun et al.   NUCLEIC ACIDS RESEARCH

TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity

(2019) Alexandra M. Pike et al.   MOLECULAR AND CELLULAR BIOLOGY

SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

(2019) Stephanie Panier et al.   MOLECULAR CELL

POT1-TPP1 differentially regulates telomerase via POT1 His266 and as a function of single-stranded telomere DNA length

(2019) Mengyuan Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression

(2019) Alyssa La Belle Flynn et al.   Nature Communications

Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2

(2018) Aaron Mendez-Bermudez et al.   MOLECULAR CELL

Telomere sequence content can be used to determine ALT activity in tumours

(2018) Michael Lee et al.   NUCLEIC ACIDS RESEARCH

Role of the NFκB-signaling pathway in cancer

(2018) Longzheng Xia et al.   OncoTargets and Therapy

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

(2018) Juan J. Montero et al.   Nature Communications

Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9

(2018) Francis P. McManus et al.   Scientific Reports

Administration of a Nucleoside Analog Promotes Cancer Cell Death in a Telomerase-Dependent Manner

(2018) Xuehuo Zeng et al.   Cell Reports

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation

(2017) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres

(2017) Xiaolei Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Lengthening of Telomeres: DNA Repair Pathways Converge

(2017) Alexander P. Sobinoff et al.   TRENDS IN GENETICS

Mutant p53 dictates the oncogenic activity of c-Abl in triple-negative breast cancers

(2017) Chevaun D Morrison et al.   Cell Death & Disease

Structural and functional analysis of the human POT1-TPP1 telomeric complex

(2017) Cory Rice et al.   Nature Communications

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation

(2017) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The lncRNA BORG Drives Breast Cancer Metastasis and Disease Recurrence

(2017) Alex J. Gooding et al.   Scientific Reports

Means to the ends: The role of telomeres and telomere processing machinery in metastasis

(2016) Nathaniel J. Robinson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner

(2016) Sung-Hak Kim et al.   CANCER CELL

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor

(2016) Ning Liu et al.   NUCLEIC ACIDS RESEARCH

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions

(2016) Rekha Rai et al.   Nature Communications

Repressor and activator protein accelerates hepatic ischemia reperfusion injury by promoting neutrophil inflammatory response

(2016) Chang Xian Li et al.   Oncotarget

Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease

(2016) Xiao-qin Wu et al.   Scientific Reports

Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition

(2016) Katharina I. Deeg et al.   Frontiers in Oncology

JASSA: a comprehensive tool for prediction of SUMOylation sites and SIMs

(2015) Guillaume Beauclair et al.   BIOINFORMATICS

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites

(2015) R. Gonzalez-Prieto et al.   EMBO REPORTS

PIAS1-mediated sumoylation promotes STUbL-dependent proteasomal degradation of the human telomeric protein TRF2

(2015) Joonyoung Her et al.   FEBS LETTERS

Human telomerase: biogenesis, trafficking, recruitment, and activation

(2015) Jens C. Schmidt et al.   GENES & DEVELOPMENT

Beginning at the end: DNA replication within the telomere

(2015) Susan A. Gerbi   JOURNAL OF CELL BIOLOGY

System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability

(2015) Zhenyu Xiao et al.   MOLECULAR & CELLULAR PROTEOMICS

The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability

(2015) Jean-Hugues Guervilly et al.   MOLECULAR CELL

Noncovalent Interactions with SUMO and Ubiquitin Orchestrate Distinct Functions of the SLX4 Complex in Genome Maintenance

(2015) Jian Ouyang et al.   MOLECULAR CELL

Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development

(2015) Rong Deng et al.   Oncotarget

Signal Transduction in Cancer

(2015) R. Sever et al.   Cold Spring Harbor Perspectives in Medicine

The functional diversity of protein lysine methylation

(2014) S. Lanouette et al.   Molecular Systems Biology

Uncovering global SUMOylation signaling networks in a site-specific manner

(2014) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GPS-SUMO: a tool for the prediction of sumoylation sites and SUMO-interaction motifs

(2014) Qi Zhao et al.   NUCLEIC ACIDS RESEARCH

NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation

(2014) M P Licciardello et al.   ONCOGENE

SUMOylation regulates AKT1 activity

(2014) C F de la Cruz-Herrera et al.   ONCOGENE

p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1

(2013) Aleixo Santiago et al.   MOLECULAR BIOLOGY OF THE CELL

Correlation of Chromosomal Instability, Telomere Length and Telomere Maintenance in Microsatellite Stable Rectal Cancer: A Molecular Subclass of Rectal Cancer

(2013) Lisa A. Boardman et al.   PLoS One

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres

(2013) Bingbing Wan et al.   Cell Reports

Localization-Dependent and -Independent Roles of SLX4 in Regulating Telomeres

(2013) Jamie S.J. Wilson et al.   Cell Reports

RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression

(2013) Paula Martínez et al.   Cell Reports

Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy

(2013) P. Godwin et al.   Frontiers in Oncology

p85α SH2 Domain Phosphorylation by IKK Promotes Feedback Inhibition of PI3K and Akt in Response to Cellular Starvation

(2012) William C. Comb et al.   MOLECULAR CELL

Telomerase directly regulates NF-κB-dependent transcription

(2012) Arkasubhra Ghosh et al.   NATURE CELL BIOLOGY

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

(2012) Wanjuan Yang et al.   NUCLEIC ACIDS RESEARCH

Detection of alternative lengthening of telomeres by telomere quantitative PCR

(2012) Loretta M. S. Lau et al.   NUCLEIC ACIDS RESEARCH

Ab initio protein structure assembly using continuous structure fragments and optimized knowledge-based force field

(2012) Dong Xu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Signaling in Cell Differentiation and Morphogenesis

(2012) M. A. Basson   Cold Spring Harbor Perspectives in Biology

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

NF-kappaB p65 modulates the telomerase reverse transcriptase in the HepG2 hepatoma cell line

(2011) Qing-Ping Zuo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Reversible SUMOylation of TBL1-TBLR1 Regulates β-Catenin-Mediated Wnt Signaling

(2011) Hyo-Kyoung Choi et al.   MOLECULAR CELL

Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells

(2011) E. Varela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRF1 Mediates Mitotic Abnormalities Induced by Aurora-A Overexpression

(2010) T. Ohishi et al.   CANCER RESEARCH

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers

(2010) Jeremy D. Henson et al.   FEBS LETTERS

Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression

(2010) Hsiangling Teo et al.   NATURE CELL BIOLOGY

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

(2010) Paula Martinez et al.   NATURE CELL BIOLOGY

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor

(2010) B. Sehat et al.   Science Signaling

Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

(2009) Jennifer M. Svendsen et al.   CELL

Purification of Proteins Associated with Specific Genomic Loci

(2009) Jérôme Déjardin et al.   CELL

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

(2009) Rosa M. Marion et al.   Cell Stem Cell

The Shelterin Protein TRF2 Inhibits Chk2 Activity at Telomeres in the Absence of DNA Damage

(2009) Giacomo Buscemi et al.   CURRENT BIOLOGY

Human RAP1 inhibits non-homologous end joining at telomeres

(2009) Jay Sarthy et al.   EMBO JOURNAL

In VivoStoichiometry of Shelterin Components

(2009) Kaori K. Takai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-linked Inhibitor of Apoptosis Protein and Its E3 Ligase Activity Promote Transforming Growth Factor-β-mediated Nuclear Factor-κB Activation during Breast Cancer Progression

(2009) Jason R. Neil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MLL Associates with Telomeres and Regulates Telomeric Repeat-Containing RNA Transcription

(2009) C. Caslini et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomeric DNA Mediates De Novo PML Body Formation

(2009) Anneke K. Brouwer et al.   MOLECULAR BIOLOGY OF THE CELL

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

A role for monoubiquitinated FANCD2 at telomeres in ALT cells

(2009) Qiang Fan et al.   NUCLEIC ACIDS RESEARCH

How Telomeres Solve the End-Protection Problem

(2009) T. de Lange   SCIENCE

Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-β signaling

(2008) Seiyu Imoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Altered TAB1:I B Kinase Interaction Promotes Transforming Growth Factor  -Mediated Nuclear Factor- B Activation during Breast Cancer Progression

(2008) J. R. Neil et al.   CANCER RESEARCH

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance

(2008) Tae Ho Lee et al.   NATURE CELL BIOLOGY

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

(2008) Brendan Jones et al.   PLoS Genetics