Progress in Understanding the Genetic Information and Biosynthetic Pathways behindAmycolatopsisAntibiotics, with Implications for the Continued Discovery of Novel Drugs

Construction of a New Class of Tetracycline Lead Structures with Potent Antibacterial Activity through Biosynthetic Engineering

(2015) Urška Lešnik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

(2015) Kristina Haslinger et al.   NATURE

Antibiotic Resistance Mechanisms Inform Discovery: Identification and Characterization of a Novel Amycolatopsis Strain Producing Ristocetin

(2014) Andrew W. Truman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Overproduction of Ristomycin A by Activation of a Silent Gene Cluster in Amycolatopsis japonicum MG417-CF17

(2014) Marius Spohn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis

(2014) Li Xu et al.   BMC GENOMICS

Multidrug-resistant and extensively drug-resistant Gram-negative pathogens: current and emerging therapeutic approaches

(2014) Ilias Karaiskos et al.   EXPERT OPINION ON PHARMACOTHERAPY

Activation and Products of the Cryptic Secondary Metabolite Biosynthetic Gene Clusters by Rifampin Resistance (rpoB) Mutations in Actinomycetes

(2013) Y. Tanaka et al.   JOURNAL OF BACTERIOLOGY

A regulatory gene (ECO-orf4 ) required for ECO-0501 biosynthesis in Amycolatopsis orientalis

(2013) Yang Shen et al.   JOURNAL OF BASIC MICROBIOLOGY

Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways

(2013) Gregory L. Challis   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Genome mining of Streptomyces ambofaciens

(2013) Bertrand Aigle et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Identification of the chelocardin biosynthetic gene cluster from Amycolatopsis sulphurea: a platform for producing novel tetracycline antibiotics

(2013) T. Lukezic et al.   MICROBIOLOGY-SGM

Synthetic Biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production

(2012) Wolfgang Wohlleben et al.   FEBS LETTERS

Study of Vancomycin Resistance in Faecal Enterococci from Healthy Humans and Dogs in Spain a Decade after the Avoparcin Ban in Europe

(2012) M. López et al.   Zoonoses and Public Health

Two genes, rif15 and rif16, of the rifamycin biosynthetic gene cluster in Amycolatopsis mediterranei likely encode a transketolase and a P450 monooxygenase, respectively, both essential for the conversion of rifamycin SV into B

(2011) H. Yuan et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism

(2010) Wei Zhao et al.   CELL RESEARCH

Rifamycins – Obstacles and opportunities

(2010) Paul A. Aristoff et al.   TUBERCULOSIS

Structure of ristocetin A in complex with a bacterial cell-wall mimetic

(2009) Virginie Nahoum et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Biosynthesis, biotechnological production, and application of teicoplanin: current state and perspectives

(2009) Hyung-Moo Jung et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Chimeric Glycosyltransferases for the Generation of Hybrid Glycopeptides

(2009) Andrew W. Truman et al.   CHEMISTRY & BIOLOGY

The A–Z of bacterial translation inhibitors

(2009) Daniel N. Wilson   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Amycolatopsis halophila sp. nov., a halophilic actinomycete isolated from a salt lake

(2009) S. K. Tang et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

(2009) Takeshi Hosaka et al.   NATURE BIOTECHNOLOGY