Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling

Structures of Tetrahymena ’s respiratory chain reveal the diversity of eukaryotic core metabolism

(2022) Long Zhou et al.   SCIENCE

Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle

(2022) Vasiliki Mavridou et al.   Nature Communications

Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

(2022) Riccardo Cavalieri et al.   Molecular Metabolism

Mitochondrial uncouplers induce proton leak by activating AAC and UCP1

(2022) Ambre M. Bertholet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Molecular Dynamics Simulations of Mitochondrial Uncoupling Protein 2

(2021) Sanja Škulj et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Mechanism of Transport of Mitochondrial Carriers

(2021) J. J. Ruprecht et al.   Annual Review of Biochemistry

Mitochondrial proton leaks and uncoupling proteins

(2021) David G. Nicholls   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease

(2021) Emmanouela Tsagkaraki et al.   Nature Communications

Scalable molecular dynamics on CPU and GPU architectures with NAMD

(2020) James C. Phillips et al.   JOURNAL OF CHEMICAL PHYSICS

CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice

(2020) Chih-Hao Wang et al.   Science Translational Medicine

Structural models of mitochondrial uncoupling proteins obtained in DPC micelles are not functionally relevant

(2020) Mathilde S. Piel et al.   FEBS Journal

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

(2019) Jonathan J. Ruprecht et al.   CELL

H+ transport is an integral function of the mitochondrial ADP/ATP carrier

(2019) Ambre M. Bertholet et al.   NATURE

Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies

(2018) Christophe Chipot et al.   CHEMICAL REVIEWS

Concerns with yeast mitochondrial ADP/ATP carrier’s integrity in DPC

(2018) Martin S. King et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamics and interactions of AAC3 in DPC are not functionally relevant

(2018) Vilius Kurauskas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TTClust: A Versatile Molecular Simulation Trajectory Clustering Program with Graphical Summaries

(2018) Thibault Tubiana et al.   Journal of Chemical Information and Modeling

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism

(2014) J. J. Ruprecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dangerous Liaisons between Detergents and Membrane Proteins. The Case of Mitochondrial Uncoupling Protein 2

(2013) Manuela Zoonens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Using collective variables to drive molecular dynamics simulations

(2013) Giacomo Fiorin et al.   MOLECULAR PHYSICS

MDAnalysis: A toolkit for the analysis of molecular dynamics simulations

(2011) Naveen Michaud-Agrawal et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching

(2011) Marcelo J. Berardi et al.   NATURE

Toward the estimation of the absolute quality of individual protein structure models

(2010) Pascal Benkert et al.   BIOINFORMATICS

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Binding of ADP in the Mitochondrial ADP/ATP Carrier Is Driven by an Electrostatic Funnel

(2008) François Dehez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrostatic funneling of substrate in mitochondrial inner membrane carriers

(2008) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanism of transport by mitochondrial carriers based on analysis of symmetry

(2008) A. J. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA