Mitochondrial proton leaks and uncoupling proteins

Patch-Clamp Analysis of the Mitochondrial H+ Leak in Brown and Beige Fat

(2020) Ambre M. Bertholet et al.   Frontiers in Physiology

Purine Nucleotides in the Regulation of Brown Adipose Tissue Activity

(2020) Andrea Bast-Habersbrunner et al.   Frontiers in Endocrinology

Structural models of mitochondrial uncoupling proteins obtained in DPC micelles are not functionally relevant

(2020) Mathilde S. Piel et al.   FEBS Journal

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation

(2019) GuoXiao Wang et al.   MOLECULAR CELL

Important Trends in UCP3 Investigation

(2019) Elena E. Pohl et al.   Frontiers in Physiology

Molecular evolution of thermogenic uncoupling protein 1 and implications for medical intervention of human disease

(2019) Michael J. Gaudry et al.   MOLECULAR ASPECTS OF MEDICINE

H+ transport is an integral function of the mitochondrial ADP/ATP carrier

(2019) Ambre M. Bertholet et al.   NATURE

Switching on the furnace: Regulation of heat production in brown adipose tissue

(2019) Li Li et al.   MOLECULAR ASPECTS OF MEDICINE

Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue

(2019) Anying Song et al.   JOURNAL OF CLINICAL INVESTIGATION

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism

(2019) Jonathan J. Ruprecht et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial uncoupling, ROS generation and cardioprotection

(2018) Susana Cadenas   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies

(2018) Christophe Chipot et al.   CHEMICAL REVIEWS

Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity

(2018) Tobias Fromme et al.   Molecular Metabolism

Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1)

(2018) Petr Ježek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanisms underlying UCP1 dependent and independent adipocyte thermogenesis

(2018) Seo-Hyuk Chang et al.   Obesity Reviews

A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3

(2017) Céline Aguer et al.   FASEB JOURNAL

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

(2017) Shona A. Mookerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction

(2017) Lawrence Kazak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid

(2017) Linlin Zhao et al.   STRUCTURE

UCPs, at the interface between bioenergetics and metabolism

(2016) Frédéric Bouillaud et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Discoveries, metabolic roles and diseases of mitochondrial carriers: A review

(2016) Ferdinando Palmieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH)

(2016) Jesse G. Meyer et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

(2016) Edward T. Chouchani et al.   NATURE

The Pancreatic β-Cell: A Bioenergetic Perspective

(2016) David G. Nicholls   PHYSIOLOGICAL REVIEWS

Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin

(2015) Yang Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis

(2015) Ying Wang et al.   Nature Communications

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

(2015) Susanne Keipert et al.   Molecular Metabolism

ROS production in brown adipose tissue mitochondria: The question of UCP1-dependence

(2014) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes

(2014) Y. Li et al.   EMBO REPORTS

Sites of Superoxide and Hydrogen Peroxide Production by Muscle Mitochondria Assessedex Vivounder Conditions Mimicking Rest and Exercise

(2014) Renata L. S. Goncalves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Why to compare absolute numbers of mitochondria

(2014) Sabine Schmitt et al.   MITOCHONDRION

Mitochondrial Channels: Ion Fluxes and More

(2014) Ildiko Szabo et al.   PHYSIOLOGICAL REVIEWS

UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation

(2014) A. Vozza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Muscle uncoupling protein 3 overexpression mimics endurance training and reduces circulating biomarkers of incomplete β-oxidation

(2013) Céline Aguer et al.   FASEB JOURNAL

Fatty Acids are Key in 4-Hydroxy-2-Nonenal-Mediated Activation of Uncoupling Proteins 1 and 2

(2013) Elena A. Malingriaux et al.   PLoS One

Uncoupling and reactive oxygen species (ROS) – A double-edged sword for β-cell function? “Moderation in all things”

(2012) Sheila Collins et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak

(2012) Martin Jastroch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Fatty Acids Change the Conformation of Uncoupling Protein 1 (UCP1)

(2012) Ajit S. Divakaruni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria

(2012) Akos A. Gerencser et al.   JOURNAL OF PHYSIOLOGY-LONDON

β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

(2011) Christine A. Robson-Doucette et al.   DIABETES

Uncoupling proteins and the control of mitochondrial reactive oxygen species production

(2011) Ryan J. Mailloux et al.   FREE RADICAL BIOLOGY AND MEDICINE

Uncoupling protein-1 is not leaky

(2010) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue

(2010) Andrea Dlasková et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Transcriptional Control of Brown Fat Development

(2010) Shingo Kajimura et al.   Cell Metabolism

Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell function

(2010) J. Pi et al.   DIABETES OBESITY & METABOLISM

Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

(2010) Charles Affourtit et al.   FREE RADICAL BIOLOGY AND MEDICINE

Uncoupling Protein 1 Decreases Superoxide Production in Brown Adipose Tissue Mitochondria

(2010) Rebecca Oelkrug et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing

(2009) Frédéric Bouillaud   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production

(2009) Susanne Keipert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Persistent Oxidative Stress Due to Absence of Uncoupling Protein 2 Associated with Impaired Pancreatic β-Cell Function

(2009) Jingbo Pi et al.   ENDOCRINOLOGY

UCP2, a metabolic sensor coupling glucose oxidation to mitochondrial metabolism?

(2009) Claire Pecqueur et al.   IUBMB LIFE

Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria

(2009) Nadeene Parker et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

(2008) Camille C. Caldeira da Silva et al.   AGING CELL

Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria

(2008) Nadeene Parker et al.   BIOCHEMICAL JOURNAL

Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells

(2008) Vian Azzu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

On the role of uncoupling protein-2 in pancreatic beta cells

(2008) Charles Affourtit et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Fatty acids do not activate UCP2 in pancreatic beta cells: comparison with UCP1

(2008) Sandrine Galetti et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion

(2007) Charles Affourtit et al.   BIOCHEMICAL JOURNAL