Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

Human beige adipocytes for drug discovery and cell therapy in metabolic diseases

(2020) Amar M. Singh et al.   Nature Communications

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

(2019) Jonathan J. Ruprecht et al.   CELL

Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist

(2018) Alison S. Baskin et al.   DIABETES

The GPR120 agonist TUG‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat

(2018) Maaike Schilperoort et al.   EMBO Molecular Medicine

How Detergent Impacts Membrane Proteins: Atomic-Level Views of Mitochondrial Carriers in Dodecylphosphocholine

(2018) Vilius Kurauskas et al.   Journal of Physical Chemistry Letters

Concerns with yeast mitochondrial ADP/ATP carrier’s integrity in DPC

(2018) Martin S. King et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1)

(2018) Petr Ježek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Screening of candidate substrates and coupling ions of transporters by thermostability shift assays

(2018) Homa Majd et al.   eLife

Calcium regulation of the human mitochondrial ATP-Mg/Pi carrier SLC25A24 uses a locking pin mechanism

(2017) Steven P. D. Harborne et al.   Scientific Reports

Formation of a cytoplasmic salt bridge network in the matrix state is a fundamental step in the transport mechanism of the mitochondrial ADP/ATP carrier

(2016) Martin S. King et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

(2016) Maria Chondronikola et al.   Cell Metabolism

A Transporter of Ibuprofen is Upregulated in MDCK I Cells under Hyperosmotic Culture Conditions

(2016) Carsten Uhd Nielsen et al.   MOLECULAR PHARMACEUTICS

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Trends in Thermostability Provide Information on the Nature of Substrate, Inhibitor, and Lipid Interactions with Mitochondrial Carriers

(2015) Paul G. Crichton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin

(2015) Yang Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brite/beige fat and UCP1 — is it thermogenesis?

(2014) Susanne Keipert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

Dangerous Liaisons between Detergents and Membrane Proteins. The Case of Mitochondrial Uncoupling Protein 2

(2013) Manuela Zoonens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Cloning and ontogenetic expression of the uncoupling protein 1 gene UCP1 in sheep

(2012) Ya-Nan Yuan et al.   JOURNAL OF APPLIED GENETICS

Fatty Acids Change the Conformation of Uncoupling Protein 1 (UCP1)

(2012) Ajit S. Divakaruni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-Related Decrease in Cold-Activated Brown Adipose Tissue and Accumulation of Body Fat in Healthy Humans

(2011) Takeshi Yoneshiro et al.   Obesity

The sheep genome reference sequence: a work in progress

(2010) et al.   ANIMAL GENETICS

The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions

(2010) Jan Nedergaard et al.   Cell Metabolism

Channel character of uncoupling protein-mediated transport

(2010) Petr Ježek et al.   FEBS LETTERS

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ibuprofen: pharmacology, efficacy and safety

(2009) K. D. Rainsford   INFLAMMOPHARMACOLOGY

Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism

(2008) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Microscale Fluorescent Thermal Stability Assay for Membrane Proteins

(2008) Alexander I. Alexandrov et al.   STRUCTURE