A first-in-class inhibitor of Hsp110 molecular chaperones of pathogenic fungi
Published 2023 View Full Article
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Title
A first-in-class inhibitor of Hsp110 molecular chaperones of pathogenic fungi
Authors
Keywords
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Journal
Nature Communications
Volume 14, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-05-12
DOI
10.1038/s41467-023-38220-2
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Note: Only part of the references are listed.- Commercial Methods for Antifungal Susceptibility Testing of Yeasts: Strengths and Limitations as Predictors of Resistance
- (2022) Ana Espinel-Ingroff Journal of Fungi
- Nanofitins targeting heat shock protein 110: An innovative immunotherapeutic modality in cancer
- (2021) Guillaume Marcion et al. INTERNATIONAL JOURNAL OF CANCER
- Purification and biochemical characterization of Msi3, an essential Hsp110 molecular chaperone in Candida albicans
- (2021) Ying Wang et al. CELL STRESS & CHAPERONES
- Interdomain interactions dictate the function of the Candida albicans Hsp110 protein Msi3
- (2021) Hongtao Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach
- (2021) Leire Dublang et al. Cancers
- A novel and unique ATP hydrolysis to AMP by a human Hsp70 Binding immunoglobin protein (BiP)
- (2021) Hongtao Li et al. PROTEIN SCIENCE
- Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis
- (2021) Sarah E. Murphy et al. Frontiers in Cellular and Infection Microbiology
- Drug resistance and tolerance in fungi
- (2020) Judith Berman et al. NATURE REVIEWS MICROBIOLOGY
- Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal
- (2020) Sofia Costa-de-Oliveira et al. Microorganisms
- Transcriptome Analyses of Candida albicans Biofilms, Exposed to Arachidonic Acid and Fluconazole, Indicates Potential Drug Targets
- (2020) Oluwasegun Kuloyo et al. G3-Genes Genomes Genetics
- Discovery of Novel Pyrazolo[3,4-b] Pyridine Derivatives with Dual Activities of Vascular Remodeling Inhibition and Vasodilation for the Treatment of Pulmonary Arterial Hypertension
- (2020) Liqing Hu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus
- (2019) Luke Whitesell et al. Nature Communications
- Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy
- (2019) Gustavo J. Gozzi et al. CELL DEATH AND DIFFERENTIATION
- The Hsp70 chaperone network
- (2019) Rina Rosenzweig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Inter‐domain communication suppressing high intrinsic ATPase activity of Sse1 is essential for its co‐dissaggregase activity with Ssa1
- (2019) Vignesh Kumar et al. FEBS Journal
- Baker’s Yeast Clinical Isolates Provide a Model for How Pathogenic Yeasts Adapt to Stress
- (2019) Vandana Raghavan et al. TRENDS IN GENETICS
- Roles of the nucleotide exchange factor and chaperone Hsp110 in cellular proteostasis and diseases of protein misfolding
- (2018) Unekwu M. Yakubu et al. BIOLOGICAL CHEMISTRY
- Hsp70–Hsp110 chaperones deliver ubiquitin-dependent and -independent substrates to the 26S proteasome for proteolysis in yeast
- (2018) Ganapathi Kandasamy et al. JOURNAL OF CELL SCIENCE
- Candida albicans - Biology, molecular characterization, pathogenicity, and advances in diagnosis and control – An update
- (2018) Maryam Dadar et al. MICROBIAL PATHOGENESIS
- Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia
- (2018) Alexander Rosenberg et al. Nature Communications
- Host-Pathogen Interactions Mediated by MDR Transporters in Fungi: As Pleiotropic as it Gets!
- (2018) Mafalda Cavalheiro et al. Genes
- Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones
- (2018) Matthias P Mayer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Coordinated Hsp110 and Hsp104 Activities Power Protein Disaggregation in Saccharomyces cerevisiae
- (2017) Jayasankar Mohanakrishnan Kaimal et al. MOLECULAR AND CELLULAR BIOLOGY
- Substrate binding by the yeast Hsp110 nucleotide exchange factor and molecular chaperone Sse1 is not obligate for its biological activities
- (2017) Veronica M. Garcia et al. MOLECULAR BIOLOGY OF THE CELL
- Development and regulation of single- and multi-species Candida albicans biofilms
- (2017) Matthew B. Lohse et al. NATURE REVIEWS MICROBIOLOGY
- A Combination Fluorescence Assay Demonstrates Increased Efflux Pump Activity as a Resistance Mechanism in Azole-Resistant Vaginal Candida albicans Isolates
- (2016) Somanon Bhattacharya et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In vivo aspects of protein folding and quality control
- (2016) D. Balchin et al. SCIENCE
- Unfolding the Role of Large Heat Shock Proteins: New Insights and Therapeutic Implications
- (2016) Daming Zuo et al. Frontiers in Immunology
- Involvement of Heat Shock Protein A4/Apg-2 in Refractory Inflammatory Bowel Disease
- (2015) Teppei Adachi et al. INFLAMMATORY BOWEL DISEASES
- Prion aggregate structure in yeast cells is determined by the Hsp104-Hsp110 disaggregase machinery
- (2015) Jonathan O’Driscoll et al. JOURNAL OF CELL BIOLOGY
- How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions
- (2015) Eugenia M. Clerico et al. JOURNAL OF MOLECULAR BIOLOGY
- Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils
- (2015) Xuechao Gao et al. MOLECULAR CELL
- A Case for Two-Component Signaling Systems As Antifungal Drug Targets
- (2015) Erika Shor et al. PLoS Pathogens
- A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane
- (2015) Madhu Sudhan Ravindran et al. PLoS Pathogens
- The metazoan protein disaggregase and amyloid depolymerase system
- (2014) Mariana P Torrente et al. Prion
- The Cotranslational Function of Ribosome-Associated Hsp70 in Eukaryotic Protein Homeostasis
- (2013) Felix Willmund et al. CELL
- Hsp110 Is aBona FideChaperone Using ATP to Unfold Stable Misfolded Polypeptides and Reciprocally Collaborate with Hsp70 to Solubilize Protein Aggregates
- (2013) Rayees U. H. Mattoo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP
- (2013) Ruifeng Qi et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mutational Analysis of Sse1 (Hsp110) Suggests an Integral Role for this Chaperone in Yeast Prion Propagation In Vivo
- (2013) Ciara Moran et al. G3-Genes Genomes Genetics
- Metazoan Hsp70 machines use Hsp110 to power protein disaggregation
- (2012) Heike Rampelt et al. EMBO JOURNAL
- Candida albicans Msi3p, a homolog of the Saccharomyces cerevisiae Sse1p of the Hsp70 family, is involved in cell growth and fluconazole tolerance
- (2012) Jun-ichi Nagao et al. FEMS YEAST RESEARCH
- Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers
- (2012) Vasant Muralidharan et al. Nature Communications
- Unique Peptide Substrate Binding Properties of 110-kDa Heat-shock Protein (Hsp110) Determine Its Distinct Chaperone Activity
- (2011) Xinping Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis
- (2011) Coralie Dorard et al. NATURE MEDICINE
- The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System
- (2011) James Shorter PLoS One
- A dual function for chaperones SSB–RAC and the NAC nascent polypeptide–associated complex on ribosomes
- (2010) Ansgar Koplin et al. JOURNAL OF CELL BIOLOGY
- Hsp110 Chaperones Control Client Fate Determination in the Hsp70–Hsp90 Chaperone System
- (2010) Atin K. Mandal et al. MOLECULAR BIOLOGY OF THE CELL
- Structural Basis for the Cooperation of Hsp70 and Hsp110 Chaperones in Protein Folding
- (2008) Sigrun Polier et al. CELL
- The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding
- (2008) Jennifer L. Goeckeler et al. FEBS LETTERS
- Hsp110 Is a Nucleotide-activated Exchange Factor for Hsp70
- (2008) Claes Andréasson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of the Hsp110:Hsc70 Nucleotide Exchange Machine
- (2008) Jonathan P. Schuermann et al. MOLECULAR CELL
- Hsp110 Chaperones Regulate Prion Formation and Propagation in S. cerevisiae by Two Discrete Activities
- (2008) Heather Sadlish et al. PLoS One
- Insights into the structural dynamics of the Hsp110-Hsp70 interaction reveal the mechanism for nucleotide exchange activity
- (2008) C. Andreasson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted Disruption of Hsp110/105 Gene Protects Against Ischemic Stress
- (2008) Junji Nakamura et al. STROKE
- Exchange We Can Believe in
- (2008) Wayne A. Hendrickson et al. STRUCTURE
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