Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal

Twenty Years of the SENTRY Antifungal Surveillance Program: Results for Candida Species From 1997–2016

(2019) Michael A Pfaller et al.   Open Forum Infectious Diseases

Inhibition of Classical and Alternative Modes of Respiration in Candida albicans Leads to Cell Wall Remodeling and Increased Macrophage Recognition

(2019) Lucian Duvenage et al.   mBio

The potential of respiration inhibition as a new approach to combat human fungal pathogens

(2019) Lucian Duvenage et al.   CURRENT GENETICS

Synergistic effect of nikkomycin Z with caspofungin and micafungin against Candida albicans and Candida parapsilosis biofilms

(2019) R. Kovács et al.   LETTERS IN APPLIED MICROBIOLOGY

Pathogenetic Impact of Bacterial–Fungal Interactions

(2019) Filomena Nogueira et al.   Microorganisms

Accuracy of Sensititre YeastOne echinocandins epidemiological cut-off values for identification of FKS mutant Candida albicans and Candida glabrata : a ten year national survey of the Fungal Infection Network of Switzerland (FUNGINOS)

(2018) A. Kritikos et al.   CLINICAL MICROBIOLOGY AND INFECTION

Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline

(2018) A.J. Ullmann et al.   CLINICAL MICROBIOLOGY AND INFECTION

Biofilms and beyond: expanding echinocandin utility

(2018) Emily L Larkin et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Invasive candidiasis

(2018) Peter G. Pappas et al.   Nature Reviews Disease Primers

FK506 Resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 Involves Mutations in the Transmembrane Domains and Extracellular Loops

(2018) Koichi Tanabe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Portrait of Candida Species Biofilm Regulatory Network Genes

(2017) Daniela Araújo et al.   TRENDS IN MICROBIOLOGY

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

(2017) Jinglin L. Xie et al.   Nature Communications

Chromosome 5 of human pathogenCandida albicanscarries multiple genes for negative control of caspofungin and anidulafungin susceptibility

(2016) Sumanun Suwunnakorn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America

(2016) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach

(2016) Praveen R. Juvvadi et al.   Virulence

Ibuprofen Potentiates theIn VivoAntifungal Activity of Fluconazole against Candida albicans Murine Infection

(2015) Sofia Costa-de-Oliveira et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Echinocandins in Fungal Biofilm–Related Disease: Vascular Catheter–Related Infections, Immunomodulation, and Mucosal Surfaces

(2015) Aspasia Katragkou et al.   CLINICAL INFECTIOUS DISEASES

Defining the frontiers between antifungal resistance, tolerance and the concept of persistence

(2015) Eric Delarze et al.   DRUG RESISTANCE UPDATES

The ABCs of Candida albicans Multidrug Transporter Cdr1

(2015) Rajendra Prasad et al.   EUKARYOTIC CELL

The roles ofCDR1,CDR2,andMDR1in kaempferol-induced suppression with fluconazole-resistantCandida albicans

(2015) Jing Shao et al.   PHARMACEUTICAL BIOLOGY

Adhesion, biofilm formation, cell surface hydrophobicity, and antifungal planktonic susceptibility: relationship among Candida spp.

(2015) Ana Silva-Dias et al.   Frontiers in Microbiology

Modulation of Alternaria infectoria Cell Wall Chitin and Glucan Synthesis by Cell Wall Synthase Inhibitors

(2014) C. Fernandes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Macrophage Reporter Cell Assay for Screening Immunopharmacological Activity of Cell Wall-Active Antifungals

(2014) Russell E. Lewis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Species distribution and in vitro antifungal susceptibility profiles of yeast isolates from invasive infections during a Portuguese multicenter survey

(2014) I. Faria-Ramos et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Efficacy and safety of echinocandins versus triazoles for the prophylaxis and treatment of fungal infections: a meta-analysis of RCTs

(2014) J.-F. Wang et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Isavuconazole, a broad-spectrum triazole for the treatment of systemic fungal diseases

(2014) Seyedmojtaba Seyedmousavi et al.   Expert Review of Anti-Infective Therapy

FK520 interacts with the discrete intrahelical amino acids of multidrug transporter Cdr1 protein and acts as antagonist to selectively chemosensitize azole-resistant clinical isolates ofCandida albicans

(2014) Shweta Nim et al.   FEMS YEAST RESEARCH

Correction: Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1

(2014) Mohlopheni J. Marakalala et al.   PLoS Pathogens

Chromosome 5 Monosomy of Candida albicans Controls Susceptibility to Various Toxic Agents, Including Major Antifungals

(2013) Feng Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diagnosis and Treatment of Invasive Fungal Infections Focus on Liposomal Amphotericin B

(2013) João F. Lacerda et al.   CLINICAL DRUG INVESTIGATION

Update on antifungal resistance in Aspergillus and Candida

(2013) M.C. Arendrup   CLINICAL MICROBIOLOGY AND INFECTION

Determination of chitin content in fungal cell wall: An alternative flow cytometric method

(2013) Sofia Costa-de-Oliveira et al.   CYTOMETRY PART A

In Vitro Activities of Isavuconazole and Comparator Antifungal Agents Tested against a Global Collection of Opportunistic Yeasts and Molds

(2013) M. A. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Epidemiology of candidaemia and invasive candidiasis. A changing face

(2013) Guillermo Quindós   REVISTA IBEROAMERICANA DE MICOLOGIA

Elevated Chitin Content Reduces the Susceptibility of Candida Species to Caspofungin

(2012) Louise A. Walker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans

(2012) Clarissa J. Nobile et al.   CELL

An alternative respiratory pathway on Candida krusei: implications on susceptibility profile and oxidative stress

(2012) Sofia Costa-de-Oliveira et al.   FEMS YEAST RESEARCH

Calcium-Activated-Calcineurin Reduces the In Vitro and In Vivo Sensitivity of Fluconazole to Candida albicans via Rta2p

(2012) Yu Jia et al.   PLoS One

Paradoxical Effect of Caspofungin against Candida Bloodstream Isolates Is Mediated by Multiple Pathways but Eliminated in Human Serum

(2011) Ryan K. Shields et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reshuffling of Aspergillus fumigatus Cell Wall Components Chitin and β-Glucan under the Influence of Caspofungin or Nikkomycin Z Alone or in Combination

(2011) Patricia E. B. Verwer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Elevated Cell Wall Chitin in Candida albicans Confers Echinocandin ResistanceIn Vivo

(2011) Keunsook K. Lee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro synergisms obtained by amphotericin B and voriconazole associated with non-antifungal agents against Fusarium spp

(2011) Tarcieli P. Venturini et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Recognition and Blocking of Innate Immunity Cells by Candida albicans Chitin

(2011) Héctor M. Mora-Montes et al.   INFECTION AND IMMUNITY

Candidemia in Burn Patients: Figures and Facts

(2011) Ana Filipa Bastos Pedrosa et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates ofCandida albicans

(2010) Samantha J. Hoot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel FKS Mutations Associated with Echinocandin Resistance in Candida Species

(2010) G. Garcia-Effron et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Candida krusei reservoir in a neutropaenia unit: molecular evidence of a foe?

(2010) E. Ricardo et al.   CLINICAL MICROBIOLOGY AND INFECTION

Chitin synthesis and fungal pathogenesis

(2010) Megan D Lenardon et al.   CURRENT OPINION IN MICROBIOLOGY

Liposomal amphotericin B eradicates Candida albicans biofilm in a continuous catheter flow model

(2010) Marc Seidler et al.   FEMS YEAST RESEARCH

Management of invasive fungal infections: a role for polyenes

(2010) P. Chandrasekar   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Wild-Type MIC Distributions and Epidemiological Cutoff Values for the Triazoles and Six Aspergillus spp. for the CLSI Broth Microdilution Method (M38-A2 Document)

(2010) A. Espinel-Ingroff et al.   JOURNAL OF CLINICAL MICROBIOLOGY

An A643T Mutation in the Transcription Factor Upc2p Causes Constitutive ERG11 Upregulation and Increased Fluconazole Resistance in Candida albicans

(2009) C. J. Heilmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effect of Candida glabrata FKS1 and FKS2 Mutations on Echinocandin Sensitivity and Kinetics of 1,3- -D-Glucan Synthase: Implication for the Existing Susceptibility Breakpoint

(2009) G. Garcia-Effron et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Oral nystatin prophylaxis and neonatal fungal infections

(2009) A Howell et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Clinical Practice Guidelines for the Management of Candidiasis: 2009 Update by the Infectious Diseases Society of America

(2009) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Efflux-Mediated Antifungal Drug Resistance

(2009) R. D. Cannon et al.   CLINICAL MICROBIOLOGY REVIEWS

Hidden killers: persistence of opportunistic fungal pathogens in the human host

(2009) Christophe d’Enfert   CURRENT OPINION IN MICROBIOLOGY

Antifungal drug resistance mechanisms

(2009) Javier Pemán et al.   Expert Review of Anti-Infective Therapy

Ibuprofen reverts antifungal resistance onCandida albicansshowing overexpression of CDR genes

(2009) Elisabete Ricardo et al.   FEMS YEAST RESEARCH

Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation

(2009) Dominique Sanglard et al.   FEMS YEAST RESEARCH

Regulation of multidrug resistance in pathogenic fungi

(2009) Joachim Morschhäuser   FUNGAL GENETICS AND BIOLOGY

The alternative oxidase of Candida albicans causes reduced fluconazole susceptibility

(2009) L. Yan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In vitro activity of isavuconazole against Trichosporon, Rhodotorula, Geotrichum, Saccharomyces and Pichia species

(2009) G. R. Thompson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

(2009) Sheena D. Singh et al.   PLoS Pathogens

ABC Transporter Cdr1p Contributes More than Cdr2p Does to Fluconazole Efflux in Fluconazole-Resistant Candida albicans Clinical Isolates

(2008) A. R. Holmes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Correlating Echinocandin MIC and Kinetic Inhibition of fks1 Mutant Glucan Synthases for Candida albicans: Implications for Interpretive Breakpoints

(2008) G. Garcia-Effron et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Propofol lipidic infusion promotes resistance to antifungals by reducing drug input into the fungal cell

(2008) Sofia Costa-de-Oliveira et al.   BMC MICROBIOLOGY

The changing epidemiology of invasive candidiasis

(2008) Ray Hachem et al.   CANCER

Stress, Drugs, and Evolution: the Role of Cellular Signaling in Fungal Drug Resistance

(2008) Leah E. Cowen et al.   EUKARYOTIC CELL

A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a ClinicalCandida albicansIsolate

(2008) Nico Dunkel et al.   EUKARYOTIC CELL

A first Portuguese epidemiological survey of fungaemia in a university hospital

(2008) S. Costa-de-Oliveira et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Clinical relevance of resistance to antifungals

(2008) Juan Luis Rodriguez-Tudela et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Comparative pharmacodynamic interaction analysis between ciprofloxacin, moxifloxacin and levofloxacin and antifungal agents against Candida albicans and Aspergillus fumigatus

(2008) T. Stergiopoulou et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Rifampicin induces MDR1 expression in Candida albicans

(2008) Miriam Vogel et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mutations in the multi-drug resistance regulatorMRR1, followed by loss of heterozygosity, are the main cause ofMDR1overexpression in fluconazole-resistantCandida albicansstrains

(2008) Nico Dunkel et al.   MOLECULAR MICROBIOLOGY

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1

(2008) Anna Selmecki et al.   MOLECULAR MICROBIOLOGY

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype

(2008) Leah E. Cowen   NATURE REVIEWS MICROBIOLOGY

Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters

(2008) E. A. Dubikovskaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of Chitin Synthesis Rescues Candida albicans from Echinocandins

(2008) Louise A. Walker et al.   PLoS Pathogens

Resistance to Antifungal Agents: Mechanisms and Clinical Impact

(2007) Z. A. Kanafani et al.   CLINICAL INFECTIOUS DISEASES