Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

Cancer–neuronal crosstalk and the startups working to silence it

(2020) Elie Dolgin   NATURE BIOTECHNOLOGY

Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells

(2020) Tomoyuki Koga et al.   Nature Communications

Methylome analyses of three glioblastoma cohorts reveal chemotherapy sensitivity markers within DDR genes

(2020) Tobias Kessler et al.   Cancer Medicine

Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma

(2020) Elena Parmigiani et al.   Cells

Tumor cell network integration in glioma represents a stemness feature

(2020) Ruifan Xie et al.   NEURO-ONCOLOGY

Role of Notch Signaling Pathway in Glioblastoma Multiforme Pathogenesis

(2019) Riccardo Bazzoni et al.   Cancers

Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion

(2019) Maria Alieva et al.   Scientific Reports

Developmental origins and emerging therapeutic opportunities for childhood cancer

(2019) Mariella Filbin et al.   NATURE MEDICINE

Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity

(2019) Saran Kumar et al.   Cell Metabolism

Therapeutic Targeting of the Notch Pathway in Glioblastoma

(2019) Zachary Gersey et al.   World Neurosurgery

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

The phenotypes of proliferating glioblastoma cells reside on a single axis of variation

(2019) Lin Wang et al.   Cancer Discovery

Emerging intersections between neuroscience and glioma biology

(2019) Erik Jung et al.   NATURE NEUROSCIENCE

Computational modeling demonstrates that glioblastoma cells can survive spatial environmental challenges through exploratory adaptation

(2019) Orieta Celiku et al.   Nature Communications

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience

(2018) David Capper et al.   ACTA NEUROPATHOLOGICA

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Notch1 is a prognostic factor that is distinctly activated in the classical and proneural subtype of glioblastoma and that promotes glioma cell survival via the NF-κB(p65) pathway

(2018) Long Hai et al.   Cell Death & Disease

Human glioblastoma arises from subventricular zone cells with low-level driver mutations

(2018) Joo Ho Lee et al.   NATURE

Tweety-Homolog 1 Drives Brain Colonization of Gliomas

(2017) Erik Jung et al.   JOURNAL OF NEUROSCIENCE

Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas

(2017) Sophie Weil et al.   NEURO-ONCOLOGY

Notch1 ablation radiosensitizes glioblastoma cells

(2017) Na Han et al.   Oncotarget

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells

(2017) N. Sumru Bayin et al.   Oncotarget

Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior

(2017) Maria Alieva et al.   Scientific Reports

The pathological structure of the perivascular niche in different microvascular patterns of glioblastoma

(2017) Jintao Chen et al.   PLoS One

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial

(2016) R. Xu et al.   CLINICAL CANCER RESEARCH

A malignant cellular network in gliomas: potential clinical implications

(2016) Matthias Osswald et al.   NEURO-ONCOLOGY

ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway

(2016) Mingli Liu et al.   Oncotarget

NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma

(2016) Sanaz Yahyanejad et al.   Oncotarget

It Takes a Village: Constructing the Neurogenic Niche

(2015) Christopher S. Bjornsson et al.   DEVELOPMENTAL CELL

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Classification of microvascular patterns via cluster analysis reveals their prognostic significance in glioblastoma

(2015) Long Chen et al.   HUMAN PATHOLOGY

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Glioma

(2015) Michael Weller et al.   Nature Reviews Disease Primers

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

(2012) Pierre Bady et al.   ACTA NEUROPATHOLOGICA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Comparative assessment of 5 methods (methylation-specific polymerase chain reaction, methylight, pyrosequencing, methylation-sensitive high-resolution melting, and immunohistochemistry) to analyze O6-methylguanine-DNA-methyltranferase in a series of 100 g

(2012) Véronique Quillien et al.   CANCER

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Addressing Diffuse Glioma as a Systemic Brain Disease With Single-Cell Analysis

(2011) David Capper   ARCHIVES OF NEUROLOGY

Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells

(2011) T. S. Zhu et al.   CANCER RESEARCH

Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment

(2011) Justin D. Lathia et al.   Cell Stem Cell

Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas

(2011) Jörg Felsberg et al.   INTERNATIONAL JOURNAL OF CANCER

Predictive impact of MGMT promoter methylation in glioblastoma of the elderly

(2011) Guido Reifenberger et al.   INTERNATIONAL JOURNAL OF CANCER

Twisted tango: brain tumor neurovascular interactions

(2011) Anita B Hjelmeland et al.   NATURE NEUROSCIENCE

The stem cell potential of glia: lessons from reactive gliosis

(2011) Stefanie Robel et al.   NATURE REVIEWS NEUROSCIENCE

Direct In Vivo Evidence for Tumor Propagation by Glioblastoma Cancer Stem Cells

(2011) Justin D. Lathia et al.   PLoS One

The perivascular niche microenvironment in brain tumor progression

(2010) Nikki A Charles et al.   CELL CYCLE

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Mitochondrial DNA Integrity Is Essential For Mitochondrial Maturation During Differentiation of Neural Stem Cells

(2010) Wei Wang et al.   STEM CELLS

Characterization of R132H Mutation-specific IDH1 Antibody Binding in Brain Tumors

(2009) David Capper et al.   BRAIN PATHOLOGY