An evolutionary shift in the regulation of the Hippo pathway between mice and flies

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Planar Polarity Specification through Asymmetric Subcellular Localization of Fat and Dachsous

(2012) Amy Brittle et al.   CURRENT BIOLOGY

Propagation of Dachsous-Fat Planar Cell Polarity

(2012) Abhijit A. Ambegaonkar et al.   CURRENT BIOLOGY

Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous

(2012) H. Matakatsu et al.   DEVELOPMENT

Growth Control by Committee: Intercellular Junctions, Cell Polarity, and the Cytoskeleton Regulate Hippo Signaling

(2012) Julian C. Boggiano et al.   DEVELOPMENTAL CELL

The Cell Adhesion Molecule Echinoid Functions as a Tumor Suppressor and Upstream Regulator of the Hippo Signaling Pathway

(2012) Tao Yue et al.   DEVELOPMENTAL CELL

Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila

(2012) Masato Enomoto et al.   EMBO REPORTS

Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene

(2012) Christian J. Gaffney et al.   GENE

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Myosin-X functions in polarized epithelial cells

(2012) Katy C. Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanical Control of Morphogenesis by Fat/Dachsous/Four-Jointed Planar Cell Polarity Pathway

(2012) F. Bosveld et al.   SCIENCE

Premetazoan Origin of the Hippo Signaling Pathway

(2012) Arnau Sebé-Pedrós et al.   Cell Reports

The Hippo pathway and apico–basal cell polarity

(2011) Alice Genevet et al.   BIOCHEMICAL JOURNAL

Structural Features and Ligand Binding Properties of Tandem WW Domains from YAP and TAZ, Nuclear Effectors of the Hippo Pathway

(2011) Claire Webb et al.   BIOCHEMISTRY

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

FatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell pools

(2011) N. J. Van Hateren et al.   DEVELOPMENT

Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development

(2011) Y. Mao et al.   DEVELOPMENT

Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila

(2011) Y. Mao et al.   GENES & DEVELOPMENT

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin

(2011) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelia, an Evolutionary Novelty of Metazoans

(2011) Sally P. Leys et al.   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

The Evolutionary History of YAP and the Hippo/YAP Pathway

(2011) D. Hilman et al.   MOLECULAR BIOLOGY AND EVOLUTION

Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP

(2011) T Oka et al.   ONCOGENE

Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP

(2011) L Angus et al.   ONCOGENE

Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway

(2011) S Visser-Grieve et al.   ONCOGENE

Integrating developmental signals: a Hippo in the (path)way

(2011) A Mauviel et al.   ONCOGENE

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

(2011) N.-G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling

(2010) Tsutomu Oka et al.   BIOCHEMICAL JOURNAL

Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development

(2010) J Avruch et al.   BRITISH JOURNAL OF CANCER

YAP is a candidate oncogene for esophageal squamous cell carcinoma

(2010) Tomoki Muramatsu et al.   CARCINOGENESIS

Lgl, the SWH pathway and tumorigenesis: It’s a matter of context and competition!

(2010) Nicola A Grzeschik et al.   CELL CYCLE

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

(2010) Nicola A. Grzeschik et al.   CURRENT BIOLOGY

Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded

(2010) Brian S. Robinson et al.   CURRENT BIOLOGY

Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster

(2010) C. C. Milton et al.   DEVELOPMENT

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila

(2010) Roland Baumgartner et al.   DEVELOPMENTAL CELL

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded

(2010) Jianzhong Yu et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network

(2010) Alice Genevet et al.   DEVELOPMENTAL CELL

TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner

(2010) Eline Remue et al.   FEBS LETTERS

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway

(2010) Linda M Parsons et al.   FLY

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

(2010) S. Benhamouche et al.   GENES & DEVELOPMENT

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCPE3 Ligase

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiomotin-like Proteins Associate with and Negatively Regulate YAP1

(2010) Wenqi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway

(2010) J. Menendez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

(2010) C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

(2010) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

(2010) K.-P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modularity in the Hippo signaling pathway

(2010) Marius Sudol et al.   TRENDS IN BIOCHEMICAL SCIENCES

dMyc Functions Downstream of Yorkie to Promote the Supercompetitive Behavior of Hippo Pathway Mutant Cells

(2010) Marcello Ziosi et al.   PLoS Genetics

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

The skinny on Fat: an enormous cadherin that regulates cell adhesion, tissue growth, and planar cell polarity

(2009) Richelle Sopko et al.   CURRENT OPINION IN CELL BIOLOGY

The cadherin Fat2 is required for planar cell polarity in the Drosophila ovary

(2009) I. Viktorinova et al.   DEVELOPMENT

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling

(2009) Hyangyee Oh et al.   DEVELOPMENTAL BIOLOGY

The FERM-Domain Protein Expanded Regulates Hippo Pathway Activity via Direct Interactions with the Transcriptional Activator Yorkie

(2009) Caroline Badouel et al.   DEVELOPMENTAL CELL

Nuclear localization and pro-apoptotic signaling of YAP2 require intact PDZ-binding motif

(2009) Tsutomu Oka et al.   GENES TO CELLS

Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex

(2009) Takashi Ishiuchi et al.   JOURNAL OF CELL BIOLOGY

The Crumbs complex: from epithelial-cell polarity to retinal degeneration

(2009) N. A. Bulgakova et al.   JOURNAL OF CELL SCIENCE

Crucial Role for Mst1 and Mst2 Kinases in Early Embryonic Development of the Mouse

(2009) S. Oh et al.   MOLECULAR AND CELLULAR BIOLOGY

The DHHC Palmitoyltransferase Approximated Regulates Fat Signaling and Dachs Localization and Activity

(2008) Hitoshi Matakatsu et al.   CURRENT BIOLOGY

The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation

(2008) B. V. V. G. Reddy et al.   DEVELOPMENT

Morphogen Control of Wing Growth through the Fat Signaling Pathway

(2008) Dragana Rogulja et al.   DEVELOPMENTAL CELL

Ajuba LIM Proteins Are Snail/Slug Corepressors Required for Neural Crest Development in Xenopus

(2008) Ellen M. Langer et al.   DEVELOPMENTAL CELL

Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs?

(2008) Peter A. Lawrence et al.   NATURE CELL BIOLOGY

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

(2008) Sakura Saburi et al.   NATURE GENETICS

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

(2008) P O Humbert et al.   ONCOGENE