Sleeping Giants: Emerging Roles for the Fat Cadherins in Health and Disease

Signal transduction by the Fat cytoplasmic domain

(2013) G. Pan et al.   DEVELOPMENT

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation

(2013) Luc G T Morris et al.   NATURE GENETICS

An evolutionary shift in the regulation of the Hippo pathway between mice and flies

(2013) W Bossuyt et al.   ONCOGENE

Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer

(2012) S. Lee et al.   CANCER RESEARCH

Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity

(2012) S. Saburi et al.   DEVELOPMENT

Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous

(2012) H. Matakatsu et al.   DEVELOPMENT

Drosophila egg chamber elongation

(2012) Julie Gates   FLY

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

(2012) Zhi Jiang Zang et al.   NATURE GENETICS

Cadherins in Brain Morphogenesis and Wiring

(2012) Shinji Hirano et al.   PHYSIOLOGICAL REVIEWS

EMT as the ultimate survival mechanism of cancer cells

(2012) Neha Tiwari et al.   SEMINARS IN CANCER BIOLOGY

The YAP and TAZ transcription co-activators: Key downstream effectors of the mammalian Hippo pathway

(2012) Wanjin Hong et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Hippo Pathway

(2012) K. F. Harvey et al.   Cold Spring Harbor Perspectives in Biology

A Screen for Round Egg Mutants in Drosophila Identifies Tricornered, Furry, and Misshapen as Regulators of Egg Chamber Elongation

(2012) Sally Horne-Badovinac et al.   G3-Genes Genomes Genetics

E-Cadherin and the Cytoskeletal Network in Colorectal Cancer Development and Metastasis

(2011) Andrea Buda et al.   CELL COMMUNICATION AND ADHESION

Principles of planar polarity in animal development

(2011) L. V. Goodrich et al.   DEVELOPMENT

FatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell pools

(2011) N. J. Van Hateren et al.   DEVELOPMENT

Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development

(2011) Y. Mao et al.   DEVELOPMENT

The roles of the cadherins Fat and Dachsous in planar polarity specification inDrosophila

(2011) Chloe Thomas et al.   DEVELOPMENTAL DYNAMICS

Hippo signaling inDrosophila: Recent advances and insights

(2011) Binnaz Kucuk Staley et al.   DEVELOPMENTAL DYNAMICS

Polyglutamine Atrophin provokes neurodegeneration inDrosophilaby repressingfat

(2011) Francesco Napoletano et al.   EMBO JOURNAL

Planar cell polarity

(2011) Peter A. Lawrence   FLY

Dual Processing of FAT1 Cadherin Protein by Human Melanoma Cells Generates Distinct Protein Products

(2011) Elham Sadeqzadeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Modelling planar polarity of epithelia: the role of signal relay in collective cell polarization

(2011) I. Viktorinova et al.   Journal of the Royal Society Interface

The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis–relapse samples of precursor B-cell acute lymphoblastic leukemia

(2011) C E de Bock et al.   LEUKEMIA

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

(2011) Sergey I Nikolaev et al.   NATURE GENETICS

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

(2011) Xiaomu Wei et al.   NATURE GENETICS

Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

(2011) Meng Li et al.   NATURE GENETICS

Control of Neuronal Morphology by the Atypical Cadherin Fat3

(2011) Michael R. Deans et al.   NEURON

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

Zyxin Links Fat Signaling to the Hippo Pathway

(2011) Cordelia Rauskolb et al.   PLOS BIOLOGY

An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

(2011) Irina M. Shapiro et al.   PLoS Genetics

Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development

(2010) J Avruch et al.   BRITISH JOURNAL OF CANCER

Upstream Regulation of the Hippo Size Control Pathway

(2010) Felix A. Grusche et al.   CURRENT BIOLOGY

Four-Jointed Modulates Growth and Planar Polarity by Reducing the Affinity of Dachsous for Fat

(2010) Amy L. Brittle et al.   CURRENT BIOLOGY

Modulation of Fat:Dachsous Binding by the Cadherin Domain Kinase Four-Jointed

(2010) Michael A. Simon et al.   CURRENT BIOLOGY

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

Yorkie: the final destination of Hippo signaling

(2010) Hyangyee Oh et al.   TRENDS IN CELL BIOLOGY

Connexin-based signaling in acute myelogenous leukemia (AML)

(2009) Brynjar Foss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors

(2009) Kunzang Chosdol et al.   BMC CANCER

Phosphorylation of the Tumor Suppressor Fat Is Regulated by Its Ligand Dachsous and the Kinase Discs Overgrown

(2009) Richelle Sopko et al.   CURRENT BIOLOGY

The skinny on Fat: an enormous cadherin that regulates cell adhesion, tissue growth, and planar cell polarity

(2009) Richelle Sopko et al.   CURRENT OPINION IN CELL BIOLOGY

Drosophila lowfat, a novel modulator of Fat signaling

(2009) Y. Mao et al.   DEVELOPMENT

The cadherin Fat2 is required for planar cell polarity in the Drosophila ovary

(2009) I. Viktorinova et al.   DEVELOPMENT

Atrophin Proteins Interact with the Fat1 Cadherin and Regulate Migration and Orientation in Vascular Smooth Muscle Cells

(2009) Rong Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex

(2009) Takashi Ishiuchi et al.   JOURNAL OF CELL BIOLOGY

No influence of FAT polymorphisms in response to aripiprazole

(2009) Chi-Un Pae et al.   JOURNAL OF HUMAN GENETICS

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome

(2009) Jillian L Barlow et al.   NATURE MEDICINE

In Vivo Analysis of the Notch Receptor S1 Cleavage

(2009) Robert J. Lake et al.   PLoS One

Processing and phosphorylation of the Fat receptor

(2009) Y. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

(2009) K. Skouloudaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progress and challenges in understanding planar cell polarity signaling

(2009) Jeffrey D. Axelrod   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

In vivo regulation of Yorkie phosphorylation and localization

(2008) H. Oh et al.   DEVELOPMENT

Morphogen Control of Wing Growth through the Fat Signaling Pathway

(2008) Dragana Rogulja et al.   DEVELOPMENTAL CELL

Expression patterns of cadherin genes in Drosophila oogenesis

(2008) Jeremiah J. Zartman et al.   GENE EXPRESSION PATTERNS

Identification of Fat4 as a candidate tumor suppressor gene in breast cancers

(2008) Chao Qi et al.   INTERNATIONAL JOURNAL OF CANCER

Knockdown of Fat2 by siRNA inhibits the migration of human squamous carcinoma cells

(2008) Seiya Matsui et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

(2008) Sakura Saburi et al.   NATURE GENETICS

Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation

(2008) M. Willecke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins

(2008) G. N. Huang et al.   SCIENCE

Four-jointed Is a Golgi Kinase That Phosphorylates a Subset of Cadherin Domains

(2008) H. O. Ishikawa et al.   SCIENCE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

Distal del(4) (q33) syndrome: Detailed clinical presentation and molecular description with array-CGH

(2007) Sofia Kitsiou-Tzeli et al.   European Journal of Medical Genetics