SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions

Cap-independent translation and a precisely located RNA sequence enable SARS-CoV-2 to control host translation and escape anti-viral response

(2022) Boris Slobodin et al.   NUCLEIC ACIDS RESEARCH

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

(2022) Zhang Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Translational Regulation in mTOR Pathway

(2022) Miaomiao Yang et al.   Biomolecules

The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex

(2022) Limei Zou et al.   iScience

microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development

(2021) Vinay K Mayya et al.   NUCLEIC ACIDS RESEARCH

A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome

(2021) Doyeon Kim et al.   Nature Communications

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

(2020) Aiping Wu et al.   Cell Host & Microbe

COVID‐2019: The role of the nsp2 and nsp3 in its pathogenesis

(2020) Silvia Angeletti et al.   JOURNAL OF MEDICAL VIROLOGY

Novel coronavirus treatment with ribavirin: Groundwork for an evaluation concerning COVID-19

(2020) Jahan S. Khalili et al.   JOURNAL OF MEDICAL VIROLOGY

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery

(2020) Katherine L.B. Borden et al.   RNA Biology

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

Comparative Genomic Analysis of Rapidly Evolving SARS-CoV-2 Reveals Mosaic Pattern of Phylogeographical Distribution

(2020) Roshan Kumar et al.   mSystems

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

(2020) Abhik K. Banerjee et al.   CELL

The coding capacity of SARS-CoV-2

(2020) Yaara Finkel et al.   NATURE

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

(2020) Katharina Schubert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparative Multiplexed Interactomics of SARS-CoV-2 and Homologous Coronavirus Nonstructural Proteins Identifies Unique and Shared Host-Cell Dependencies

(2020) Jonathan P. Davies et al.   ACS Infectious Diseases

The eIF4E2-Directed Hypoxic Cap-Dependent Translation Machinery Reveals Novel Therapeutic Potential for Cancer Treatment

(2017) Gaelan Melanson et al.   Oxidative Medicine and Cellular Longevity

Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements

(2016) Rui Fu et al.   RNA

Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum

(2015) Jonas J. Staudacher et al.   NUCLEIC ACIDS RESEARCH

The role of c-Src in integrin (α6β4) dependent translational control

(2013) Young Soung et al.   BMC CELL BIOLOGY

Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation

(2012) K. G. Lokugamage et al.   JOURNAL OF VIROLOGY

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

An oxygen-regulated switch in the protein synthesis machinery

(2012) James Uniacke et al.   NATURE

Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication

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Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens

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SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

(2011) Cheng Huang et al.   PLoS Pathogens

Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses

(2009) Y. Tohya et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein 2 Interacts with a Host Protein Complex Involved in Mitochondrial Biogenesis and Intracellular Signaling

(2009) C. T. Cornillez-Ty et al.   JOURNAL OF VIROLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein

(2009) Wataru Kamitani et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytoplasmic Prep1 Interacts with 4EHP Inhibiting Hoxb4 Translation

(2009) J. Carlos Villaescusa et al.   PLoS One

The Nucleocapsid Protein of Severe Acute Respiratory Syndrome Coronavirus Inhibits Cell Cytokinesis and Proliferation by Interacting with Translation Elongation Factor 1 

(2008) B. Zhou et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

(2008) K. Narayanan et al.   JOURNAL OF VIROLOGY

Coronavirus Spike Protein Inhibits Host Cell Translation by Interaction with eIF3f

(2008) Han Xiao et al.   PLoS One

FGF2 Translationally Induced by Hypoxia Is Involved in Negative and Positive Feedback Loops with HIF-1α

(2008) Caroline Conte et al.   PLoS One