The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex

The X-ray crystallography phase problem solved thanks to AlphaFold and RoseTTAFold models: a case-study report

(2022) Irène Barbarin-Bocahu et al.   Acta Crystallographica Section D-Structural Biology

microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP

(2021) Xu Zhang et al.   MOLECULAR CELL

Molecular Epidemiology Surveillance of SARS-CoV-2: Mutations and Genetic Diversity One Year after Emerging

(2021) Alejandro Flores-Alanis et al.   Pathogens

SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis

(2021) Yaara Finkel et al.   NATURE

Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of three proteins from SARS-CoV-2

(2021) Moriya Slavin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Function of N-Terminal Zinc Finger Domain of SARS-CoV-2 NSP2

(2021) Jun Ma et al.   VIROLOGICA SINICA

Partial structure, dampened mobility, and modest impact of a His tag in the SARS-CoV-2 Nsp2 C-terminal region

(2021) Miguel Mompeán et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

eIF4E‐homologous protein (4EHP): a multifarious cap‐binding protein

(2021) Mary Christie et al.   FEBS Journal

SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes

(2021) Paulina Pawlica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COVID‐2019: The role of the nsp2 and nsp3 in its pathogenesis

(2020) Silvia Angeletti et al.   JOURNAL OF MEDICAL VIROLOGY

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for Comorbidities

(2020) Elif Damla Arisan et al.   Viruses-Basel

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

(2020) Sepideh Sadegh et al.   Nature Communications

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

(2020) Abhik K. Banerjee et al.   CELL

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

(2020) David E. Gordon et al.   SCIENCE

Prediction and Analysis of SARS-CoV-2-Targeting MicroRNA in Human Lung Epithelium

(2020) Jonathan Tak-Sum Chow et al.   Genes

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

(2020) H.-Heinrich Hoffmann et al.   Cell Host & Microbe

Comparative Multiplexed Interactomics of SARS-CoV-2 and Homologous Coronavirus Nonstructural Proteins Identifies Unique and Shared Host-Cell Dependencies

(2020) Jonathan P. Davies et al.   ACS Infectious Diseases

GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling

(2019) Maxim A.X. Tollenaere et al.   Cell Reports

4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2

(2018) Cinthia C Amaya Ramirez et al.   NUCLEIC ACIDS RESEARCH

Translational control of ERK signaling through miRNA/4EHP-directed silencing

(2018) Seyed Mehdi Jafarnejad et al.   eLife

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression

(2017) Daniel Peter et al.   GENES & DEVELOPMENT

Alternative splicing of CNOT7 diversifies CCR4–NOT functions

(2017) Clément Chapat et al.   NUCLEIC ACIDS RESEARCH

Cap-binding protein 4EHP effects translation silencing by microRNAs

(2017) Clément Chapat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

(2017) Aitor Garzia et al.   Nature Communications

Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes

(2017) Isabel Myriam Schopp et al.   Nature Communications

MicroRNAs recruit eIF4E2 to repress translation of target mRNAs

(2017) Shaohong Chen et al.   Protein & Cell

Viruses and miRNAs: More Friends than Foes

(2017) Patrice Bruscella et al.   Frontiers in Microbiology

Post-transcriptional gene silencing activity of human GIGYF2

(2016) Marie-Hélène Kryszke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements

(2016) Rui Fu et al.   RNA

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

(2014) Stephen W. Eichhorn et al.   MOLECULAR CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies

(2012) Tina W. Han et al.   CELL

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells

(2012) Julien Béthune et al.   EMBO REPORTS

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein 2 Interacts with a Host Protein Complex Involved in Mitochondrial Biogenesis and Intracellular Signaling

(2009) C. T. Cornillez-Ty et al.   JOURNAL OF VIROLOGY

Cytoplasmic Prep1 Interacts with 4EHP Inhibiting Hoxb4 Translation

(2009) J. Carlos Villaescusa et al.   PLoS One

Charged single α-helix: A versatile protein structural motif

(2008) Dániel Süveges et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

(2008) M. Landthaler et al.   RNA