Potential for Early Noninvasive COVID-19 Detection Using Electronic-Nose Technologies and Disease-Specific VOC Metabolic Biomarkers

Breath Analysis of COVID-19 Patients in a Tertiary UK Hospital by Optical Spectrometry: The E-Nose CoVal Study

(2023) Steven Laird et al.   Biosensors-Basel

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

(2022) Feargal J. Ryan et al.   BMC Medicine

Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae

(2022) Yapeng Su et al.   CELL

Consequences of COVID-19 for the Pancreas

(2022) Urszula Abramczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

(2022) Chansavath Phetsouphanh et al.   NATURE IMMUNOLOGY

Pathological sequelae of long-haul COVID

(2022) Saurabh Mehandru et al.   NATURE IMMUNOLOGY

Biomarker Metabolites Discriminate between Physiological States of Field, Cave and White-nose Syndrome Diseased Bats

(2022) Anna C. Doty et al.   SENSORS

Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection

(2022) Bruce K. Patterson et al.   Frontiers in Immunology

Post-COVID syndrome screening through breath analysis using electronic nose technology

(2022) Nidheesh V. R. et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Understanding on the possible routes for SARS CoV-2 invasion via ACE2 in the host linked with multiple organs damage

(2022) Nikhil Kirtipal et al.   INFECTION GENETICS AND EVOLUTION

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

(2022) Gwenaëlle Douaud et al.   NATURE

The immunology and immunopathology of COVID-19

(2022) Miriam Merad et al.   SCIENCE

An electronic nose based on carbon nanotube -titanium dioxide hybrid nanostructures for detection and discrimination of volatile organic compounds

(2022) Mostafa Shooshtari et al.   SENSORS AND ACTUATORS B-CHEMICAL

COVID-19 mortality is associated with pre-existing impaired innate immunity in health conditions

(2022) Matthew Lee et al.   PeerJ

An Experimental Apparatus for E-Nose Breath Analysis in Respiratory Failure Patients

(2022) Carmen Bax et al.   Diagnostics

Hybrid learning method based on feature clustering and scoring for enhanced COVID-19 breath analysis by an electronic nose

(2022) Shidiq Nur Hidayat et al.   ARTIFICIAL INTELLIGENCE IN MEDICINE

Nutraceuticals and Dietary Supplements for Older Adults with Long COVID-19

(2022) Matteo Tosato et al.   CLINICS IN GERIATRIC MEDICINE

Fast and noninvasive electronic nose for sniffing out COVID-19 based on exhaled breath-print recognition

(2022) Dian Kesumapramudya Nurputra et al.   npj Digital Medicine

Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae

(2022) Zoe Swank et al.   CLINICAL INFECTIOUS DISEASES

COVID‐19 immunopathology: From acute diseases to chronic sequelae

(2022) Mohd Arish et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical studies of detecting COVID-19 from exhaled breath with electronic nose

(2022) Andrzej Kwiatkowski et al.   Scientific Reports

The Renin–Angiotensin-Aldosterone System, Nitric Oxide, and Hydrogen Sulfide at the Crossroads of Hypertension and COVID-19: Racial Disparities and Outcomes

(2022) Tara Ranjbar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Electronic Nose Sensor Drift Affects Diagnostic Reliability and Accuracy of Disease-Specific Algorithms

(2022) Sofie Bosch et al.   SENSORS

Expert considerations and consensus for using dogs to detect human SARS-CoV-2-infections

(2022) Sebastian Meller et al.   Frontiers in Medicine

Canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event

(2022) Nele Alexandra ten Hagen et al.   BMJ Global Health

Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

(2021) Yun Kit Yeoh et al.   GUT

Six-Month Follow-up Chest CT findings after Severe COVID-19 Pneumonia

(2021) Xiaoyu Han et al.   RADIOLOGY

Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening

(2021) Daniel B. Larremore et al.   Science Advances

A breath of fresh air – the potential for COVID-19 breath diagnostics

(2021) Cristina E. Davis et al.   EBioMedicine

Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers

(2021) François-Xavier Danlos et al.   Cell Death & Disease

Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

(2021) Nan Xiao et al.   Nature Communications

A novel cell culture system modeling the SARS-CoV-2 life cycle

(2021) Xiaohui Ju et al.   PLoS Pathogens

Pathogenesis of Multiple Organ Injury in COVID-19 and Potential Therapeutic Strategies

(2021) Miquéias Lopes-Pacheco et al.   Frontiers in Physiology

Metabolite reanalysis revealed potential biomarkers for COVID-19: a potential link with immune response

(2021) Xin Chen et al.   Future Microbiology

Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients

(2021) Judith Marín-Corral et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy

(2021) Matthew J. McConnell et al.   JOURNAL OF HEPATOLOGY

The serum metabolome of COVID-19 patients is distinctive and predictive

(2021) Ding Shi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A molecular single-cell lung atlas of lethal COVID-19

(2021) Johannes C. Melms et al.   NATURE

Post-acute COVID-19 syndrome

(2021) Ani Nalbandian et al.   NATURE MEDICINE

Discrimination of SARS-CoV-2 infected patient samples by detection dogs: A proof of concept study

(2021) Jennifer L. Essler et al.   PLoS One

Biomarkers in COVID-19: An Up-To-Date Review

(2021) Madhusudan Samprathi et al.   Frontiers in Pediatrics

Detecting COVID-19 from Breath: A Game Changer for a Big Challenge

(2021) Giorgia Giovannini et al.   ACS Sensors

Angiotensin-(1-7)—A Potential Remedy for AKI: Insights Derived from the COVID-19 Pandemic

(2021) Samuel N. Heyman et al.   Journal of Clinical Medicine

Ultrafast multiplexed detection of SARS-CoV-2 RNA using a rapid droplet digital PCR system

(2021) Hao Yin et al.   BIOSENSORS & BIOELECTRONICS

Application of chemoresistive gas sensors and chemometric analysis to differentiate the fingerprints of global volatile organic compounds from diseases. Preliminary results of COPD, lung cancer and breast cancer

(2021) Maribel Rodríguez-Aguilar et al.   CLINICA CHIMICA ACTA

Proof of concept for real-time detection of SARS CoV-2 infection with an electronic nose

(2021) Kobi Snitz et al.   PLoS One

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

(2021) Nils C. Gassen et al.   Nature Communications

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

(2021) Sandra Lopez-Leon et al.   Scientific Reports

Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms

(2021) Amy D. Proal et al.   Frontiers in Microbiology

Reproducible Breath Metabolite Changes in Children with SARS-CoV-2 Infection

(2021) Amalia Z. Berna et al.   ACS Infectious Diseases

Metabolomics in the Diagnosis and Prognosis of COVID-19

(2021) Mohammad Rubayet Hasan et al.   Frontiers in Genetics

Cell Death in Coronavirus Infections: Uncovering Its Role during COVID-19

(2021) Annamaria Paolini et al.   Cells

COVID-19 and the liver: What do we know so far?

(2021) Prashant Nasa et al.   World Journal of Hepatology

The potential of volatile organic compounds-based breath analysis for COVID-19 screening: a systematic review & meta-analysis.

(2021) Anita Dominique Subali et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Portable Tools for COVID-19 Point-of-Care Detection: A Review

(2021) Elga F. Saki et al.   IEEE SENSORS JOURNAL

Exhaled nitric oxide detection for diagnosis of COVID-19 in critically ill patients

(2021) Matthew C. Exline et al.   PLoS One

Discriminative detection of volatile organic compounds using an electronic nose based on TiO2 hybrid nanostructures

(2021) Patrick P. Conti et al.   SENSORS AND ACTUATORS B-CHEMICAL

Chemometric analysis of the global pattern of volatile organic compounds in the exhaled breath of patients with COVID-19, post-COVID and healthy subjects. Proof of concept for post-COVID assessment

(2021) Blanca Nohemí Zamora-Mendoza et al.   TALANTA

Dynamic alterations in monocyte numbers, subset frequencies and activation markers in acute and convalescent COVID-19 individuals

(2021) Anuradha Rajamanickam et al.   Scientific Reports

Immune signatures underlying post-acute COVID-19 lung sequelae

(2021) I. S. Cheon et al.   Science Immunology

Ultrafast Photonic PCR Based on Photothermal Nanomaterials

(2020) Minli You et al.   TRENDS IN BIOTECHNOLOGY

Diagnosing COVID-19: The Disease and Tools for Detection

(2020) Buddhisha Udugama et al.   ACS Nano

A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development. IUPHAR Review 29

(2020) S.P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Myocardial localization of coronavirus in COVID‐19 cardiogenic shock

(2020) Guido Tavazzi et al.   EUROPEAN JOURNAL OF HEART FAILURE

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis

(2020) Francisco Alejandro Lagunas-Rangel   JOURNAL OF MEDICAL VIROLOGY

Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China

(2020) Hua Su et al.   KIDNEY INTERNATIONAL

Hyperinflammatory shock in children during COVID-19 pandemic

(2020) Shelley Riphagen et al.   LANCET

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

COVID-19: organoids go viral

(2020) Hans Clevers   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multiorgan and Renal Tropism of SARS-CoV-2

(2020) Victor G. Puelles et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures

(2020) Kenrie P Y Hui et al.   Lancet Respiratory Medicine

Scent dog identification of samples from COVID-19 patients – a pilot study

(2020) Paula Jendrny et al.   BMC INFECTIOUS DISEASES

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

(2020) Víctor J. Costela-Ruiz et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Lymphocyte Subset Counts in COVID ‐19 Patients: A Meta‐Analysis

(2020) Wei Huang et al.   CYTOMETRY PART A

A systematic review and meta‐analysis of children with Coronavirus Disease 2019 (COVID‐19)

(2020) Xiaojian Cui et al.   JOURNAL OF MEDICAL VIROLOGY

Extrapulmonary manifestations of COVID-19

(2020) Aakriti Gupta et al.   NATURE MEDICINE

The implications of silent transmission for the control of COVID-19 outbreaks

(2020) Seyed M. Moghadas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of profiles of volatile organic compounds in exhaled breath by means of an electronic nose as a proposal for a screening method for breast cancer: a case-control study

(2020) Lorena Díaz de León-Martínez et al.   Journal of Breath Research

Clinical Characteristics of Children With COVID-19: A Meta-Analysis

(2020) Yudan Ding et al.   Frontiers in Pediatrics

Long Term Culture of Human Kidney Proximal Tubule Epithelial Cells Maintains Lineage Functions and Serves as an Ex vivo Model for Coronavirus Associated Kidney Injury

(2020) Siyu Xia et al.   VIROLOGICA SINICA

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

(2020) Tiffany Thomas et al.   JCI Insight

Noninvasive Early Disease Diagnosis by Electronic-Nose and Related VOC-Detection Devices

(2020) Alphus Dan Wilson   Biosensors-Basel

Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath

(2020) Benjie Shan et al.   ACS Nano

New-Onset Type 1 Diabetes in Children During COVID-19: Multicenter Regional Findings in the U.K.

(2020) Rebecca Unsworth et al.   DIABETES CARE

The sensitivity and specificity of chest CT in the diagnosis of COVID-19

(2020) Anita Kovács et al.   EUROPEAN RADIOLOGY

Comparison of molecular testing strategies for COVID-19 control: a mathematical modelling study

(2020) Nicholas C Grassly et al.   LANCET INFECTIOUS DISEASES

Rethinking Covid-19 Test Sensitivity — A Strategy for Containment

(2020) Michael J. Mina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Harnessing nitric oxide for preventing, limiting and treating the severe pulmonary consequences of COVID-19

(2020) Nagasai C. Adusumilli et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Microfluidic devices for detection of RNA viruses

(2020) Arefeh Basiri et al.   REVIEWS IN MEDICAL VIROLOGY

Formaldehyde detection with chemical gas sensors based on WO3 nanowires decorated with metal nanoparticles under dark conditions and UV light irradiation

(2020) Benachir Bouchikhi et al.   SENSORS AND ACTUATORS B-CHEMICAL

Mechanisms of SARS-CoV-2 transmission and pathogenesis

(2020) Andrew G. Harrison et al.   TRENDS IN IMMUNOLOGY

The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

(2020) H. Blasco et al.   Scientific Reports

Virology, transmission, and pathogenesis of SARS-CoV-2

(2020) Muge Cevik et al.   BMJ-British Medical Journal

The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing

(2020) Gang Xu et al.   Cell Discovery

Toward Healthcare Diagnoses by Machine-Learning-Enabled Volatile Organic Compound Identification

(2020) Jianxiong Zhu et al.   ACS Nano

Blood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage

(2020) Yan‐Mei Chen et al.   EMBO JOURNAL

Analyses of short-chain fatty acids and exhaled breath volatiles in dietary intervention trials for metabolic diseases

(2020) Jisun HJ Lee et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2

(2020) Elettra Barberis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Can the detection dog alert on COVID-19 positive persons by sniffing axillary sweat samples? A proof-of-concept study

(2020) Dominique Grandjean et al.   PLoS One

Applying the electronic nose for pre-operative SARS-CoV-2 screening

(2020) Anne G. W. E. Wintjens et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

Nitric oxide (NO) and nanoparticles – Potential small tools for the war against COVID-19 and other human coronavirus infections

(2020) Joana C. Pieretti et al.   VIRUS RESEARCH

Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study

(2020) Stanislas Grassin-Delyle et al.   EBioMedicine

Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device

(2020) Jiyong Cheong et al.   Nature Biomedical Engineering

Diagnosis of COVID-19 for controlling the pandemic: A review of the state-of-the-art

(2020) Nastaran Taleghani et al.   BIOSENSORS & BIOELECTRONICS

The kynurenine pathway: a finger in every pie

(2019) Jonathan Savitz   MOLECULAR PSYCHIATRY

Metabolomics for Investigating Physiological and Pathophysiological Processes

(2019) David S. Wishart   PHYSIOLOGICAL REVIEWS

Prediction of response to anti-PD-1 therapy in patients with non-small-cell lung cancer by electronic nose analysis of exhaled breath

(2019) R de Vries et al.   ANNALS OF ONCOLOGY

Human Breathomics Database

(2019) Tien-Chueh Kuo et al.   Database-The Journal of Biological Databases and Curation

The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men

(2018) Christina M. van der Beek et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Feasibility and diagnostic accuracy of an electronic nose in children with asthma and cystic fibrosis

(2018) Michiel A. G. E. Bannier et al.   Journal of Breath Research

In vitro and in vivo models for studying Zika virus biology

(2018) Lindomar José Pena et al.   JOURNAL OF GENERAL VIROLOGY

Viral Infection and Apoptosis

(2017) Marc Kvansakul   Viruses-Basel

A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments

(2016) Anthony C. Dona et al.   Computational and Structural Biotechnology Journal

What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?

(2015) Ian Davis et al.   Expert Review of Neurotherapeutics

What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?

(2015) Ian Davis et al.   Expert Review of Neurotherapeutics

Measuring Compounds in Exhaled Air to Detect Alzheimer's Disease and Parkinson’s Disease

(2015) Jan-Philipp Bach et al.   PLoS One

Expiratory flow rate, breath hold and anatomic dead space influence electronic nose ability to detect lung cancer

(2015) Andras Bikov et al.   BMC Pulmonary Medicine

The volatile metabolic fingerprint of ventilator-associated pneumonia

(2014) Lieuwe D. J. Bos et al.   INTENSIVE CARE MEDICINE

A Novel Wearable Electronic Nose for Healthcare Based on Flexible Printed Chemical Sensor Array

(2014) Panida Lorwongtragool et al.   SENSORS

Assessment, origin, and implementation of breath volatile cancer markers

(2013) Hossam Haick et al.   CHEMICAL SOCIETY REVIEWS

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group

(2013) R. J. de Groot et al.   JOURNAL OF VIROLOGY

A microfluidic chip integrating DNA extraction and real-time PCR for the detection of bacteria in saliva

(2013) Emily A. Oblath et al.   LAB ON A CHIP

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

(2013) Abdullah Assiri et al.   LANCET INFECTIOUS DISEASES

Nanomaterial-based sensors for detection of disease by volatile organic compounds

(2013) Yoav Y Broza et al.   Nanomedicine

A breath test for malignant mesothelioma using an electronic nose

(2011) Eleanor A. Chapman et al.   EUROPEAN RESPIRATORY JOURNAL

Nanomaterials for cross-reactive sensor arrays

(2011) Ulrike Tisch et al.   MRS BULLETIN

Advances in Electronic-Nose Technologies Developed for Biomedical Applications

(2011) Alphus D. Wilson et al.   SENSORS

Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes

(2009) Jin-Kui Yang et al.   ACTA DIABETOLOGICA

Exhaled Breath Profiling Enables Discrimination of Chronic Obstructive Pulmonary Disease and Asthma

(2009) Niki Fens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Novel swine-origin influenza A virus in humans: another pandemic knocking at the door

(2009) Martin Michaelis et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Applications and Advances in Electronic-Nose Technologies

(2009) Alphus Wilson et al.   SENSORS

Arginase Inhibition Protects against Allergen-induced Airway Obstruction, Hyperresponsiveness, and Inflammation

(2008) Harm Maarsingh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A selective nanosensing probe for nitric oxide

(2008) P. I. Gouma et al.   APPLIED PHYSICS LETTERS

An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD

(2008) Silvano Dragonieri et al.   LUNG CANCER