Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy

Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells

(2021) Ashani Montgomery et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Acute Liver Injury in COVID‐19: Prevalence and Association with Clinical Outcomes in a Large US Cohort

(2020) Meaghan M. Phipps et al.   HEPATOLOGY

Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial

(2020) Yang Cao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Elevated Interleukin‐6 and Severe COVID‐19: A Meta‐Analysis

(2020) Muhammad Aziz et al.   JOURNAL OF MEDICAL VIROLOGY

Hypercoagulability of COVID‐19 patients in Intensive Care Unit. A Report of Thromboelastography Findings and other Parameters of Hemostasis

(2020) Mauro Panigada et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systemic inflammation as fuel for acute liver injury in COVID-19

(2020) Maria Effenberger et al.   DIGESTIVE AND LIVER DISEASE

Abnormal Liver Tests in COVID‐19: A Retrospective Observational Cohort Study of 1827 Patients in a Major U.S. Hospital Network

(2020) Melanie A. Hundt et al.   HEPATOLOGY

Liver histopathology in severe COVID 19 respiratory failure is suggestive of vascular alterations

(2020) Aurelio Sonzogni et al.   LIVER INTERNATIONAL

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

(2020) George Goshua et al.   Lancet Haematology

Postmortem Findings in Italian Patients With COVID-19: A Descriptive Full Autopsy Study of Cases With and Without Comorbidities

(2020) Laura Falasca et al.   JOURNAL OF INFECTIOUS DISEASES

IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome

(2020) Sujin Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver disease and COVID‐19: from Pathogenesis to Clinical Care

(2020) Antonio Saviano et al.   HEPATOLOGY

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

(2020) Carlos Salama et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

(2020) Tapas Patra et al.   PLoS Pathogens

Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells

(2018) Mulugeta M. Zegeye et al.   Cell Communication and Signaling

ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries

(2016) Paul Y Kwo et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice

(2016) Juri Bergmann et al.   HEPATOLOGY

IL-6 pathway in the liver: From physiopathology to therapy

(2016) Dirk Schmidt-Arras et al.   JOURNAL OF HEPATOLOGY

Soluble interleukin-6 receptor is elevated during influenza A virus infection and mediates the IL-6 and IL-32 inflammatory cytokine burst

(2014) Jun Wang et al.   Cellular & Molecular Immunology

Human liver sinusoidal endothelial cells but not hepatocytes contain factor VIII

(2013) T. Shahani et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Accumulation of platelets in the liver may be an important contributory factor to thrombocytopenia and liver fibrosis in chronic hepatitis C

(2012) Reiichiro Kondo et al.   JOURNAL OF GASTROENTEROLOGY

Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation

(2009) Prodyot K. Chatterjee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

(2008) N. Nishimoto et al.   BLOOD