Pharmacological gating modulation of small- and intermediate-conductance Ca2+-activated K+channels (KCa2.x and KCa3.1)

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

SK channels and calmodulin

(2015) John P Adelman   Channels

Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses

(2015) Maria Mathilde Haugaard et al.   HEART RHYTHM

KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction

(2015) Audrey E Padula et al.   NEUROPSYCHOPHARMACOLOGY

In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model

(2015) Lucia Hipólito et al.   PAIN

IKCa Channels Are a Critical Determinant of the Slow AHP in CA1 Pyramidal Neurons

(2015) Brian King et al.   Cell Reports

Selective phosphorylation modulates the PIP2 sensitivity of the CaM–SK channel complex

(2014) Miao Zhang et al.   Nature Chemical Biology

Development of a QPatch Automated Electrophysiology Assay for Identifying KCa3.1 Inhibitors and Activators

(2013) David Paul Jenkins et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice

(2013) Josephine Radtke et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Intermediate Conductance Calcium-activated Potassium Channel KCa3.1 Regulates Vascular Smooth Muscle Cell Proliferation via Controlling Calcium-dependent Signaling

(2013) Dan Bi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of chlorzoxazone in patients with downbeat nystagmus: A pilot trial

(2013) K. Feil et al.   NEUROLOGY

Novel Phenolic Inhibitors of Small/Intermediate-Conductance Ca2+-Activated K+ Channels, KCa3.1 and KCa2.3

(2013) Aida Oliván-Viguera et al.   PLoS One

Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation

(2013) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A High-Throughput Screening Campaign for Detection of Ca2+–Activated K+ Channel Activators and Inhibitors Using a Fluorometric Imaging Plate Reader–Based Tl+-Influx Assay

(2012) Susanne Jørgensen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Selective Positive Modulator of Calcium-Activated Potassium Channels Exerts Beneficial Effects in a Mouse Model of Spinocerebellar Ataxia Type 2

(2012) Adebimpe W. Kasumu et al.   CHEMISTRY & BIOLOGY

Trafficking of Intermediate (KCa3.1) and Small (KCa2.x) Conductance, Ca2+-Activated K+Channels: a Novel Target for Medicinal Chemistry Efforts?

(2012) Corina M. Balut et al.   ChemMedChem

Endothelial Small-Conductance and Intermediate-Conductance KCa Channels

(2012) Heike Wulff et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Increasing SK2 channel activity impairs associative learning

(2012) Bridget M. McKay et al.   JOURNAL OF NEUROPHYSIOLOGY

Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels

(2012) Miao Zhang et al.   Nature Communications

Small-Conductance Ca2+-Activated K+ Channels: Form and Function

(2011) John P. Adelman et al.   Annual Review of Physiology

Chlorzoxazone, an SK-Type Potassium Channel Activator Used in Humans, Reduces Excessive Alcohol Intake in Rats

(2011) F. Woodward Hopf et al.   BIOLOGICAL PSYCHIATRY

Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs

(2011) Mads Damkjaer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects on Atrial Fibrillation in Aged Hypertensive Rats by Ca 2+ -Activated K + Channel Inhibition

(2011) Jonas G. Diness et al.   HYPERTENSION

Early Changes in Cerebellar Physiology Accompany Motor Dysfunction in the Polyglutamine Disease Spinocerebellar Ataxia Type 3

(2011) V. G. Shakkottai et al.   JOURNAL OF NEUROSCIENCE

Negative Gating Modulation by (R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) Depends on Residues in the Inner Pore Vestibule: Pharmacological Evidence of Deep-Pore Gating of KCa2 Channels

(2011) D. P. Jenkins et al.   MOLECULAR PHARMACOLOGY

Network excitability in a model of chronic temporal lobe epilepsy critically depends on SK channel-mediated AHP currents

(2011) Robert Schulz et al.   NEUROBIOLOGY OF DISEASE

Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels

(2011) K. L. Weatherall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered expression and function of small-conductance (SK) Ca2+-activated K+ channels in pilocarpine-treated epileptic rats

(2010) Mauro S. Oliveira et al.   BRAIN RESEARCH

Allosteric Block of KCa2 Channels by Apamin

(2010) Cédric Lamy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Modulation of the Gating Properties of Small Conductance Ca2+-Activated K+ Channels Alters the Firing Pattern of Dopamine Neurons In Vivo

(2010) Kjartan F. Herrik et al.   JOURNAL OF NEUROPHYSIOLOGY

KCa Channels as Therapeutic Targets in Episodic Ataxia Type-2

(2010) K. Alvina et al.   JOURNAL OF NEUROSCIENCE

Riluzole in cerebellar ataxia: A randomized, double-blind, placebo-controlled pilot trial

(2010) G. Ristori et al.   NEUROLOGY

Endothelium-derived hyperpolarising factors and associated pathways: a synopsis

(2010) Gillian Edwards et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis

(2010) L. Di et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic potential of KCa3.1 blockers: recent advances and promising trends

(2010) Heike Wulff et al.   Expert Review of Clinical Pharmacology

Genetic Deficit of SK3 and IK1 Channels Disrupts the Endothelium-Derived Hyperpolarizing Factor Vasodilator Pathway and Causes Hypertension

(2009) Sebastian Brähler et al.   CIRCULATION

Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels

(2009) Mads Korsgaard et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Tuning the excitability of midbrain dopamine neurons by modulating the Ca2+sensitivity of SK channels

(2009) Huifang Ji et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

EF hands at the N-lobe of calmodulin are required for both SK channel gating and stable SK–calmodulin interaction

(2009) Weiyan Li et al.   JOURNAL OF GENERAL PHYSIOLOGY

Selective Activation of the SK1 Subtype of Human Small-Conductance Ca2+-Activated K+ Channels by 4-(2-Methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic Acid tert-Butyl Ester (GW542573X) Is Dependent on Serine 293 in the S5 Segment

(2009) C. Hougaard et al.   MOLECULAR PHARMACOLOGY

In vivo pharmacological manipulation of small conductance Ca2+-activated K+ channels influences motor behavior, object memory and fear conditioning

(2009) Kyle A. Vick et al.   NEUROPHARMACOLOGY

Changes of action potential and L-type calcium channel current of Sprague–Dawley rat ventricular myocytes by different amlodipine isomers

(2008) Ru-xing Wang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans

(2008) Kazuyoshi Toyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis and Structure−Activity Relationship Studies of 2-(N-Substituted)-aminobenzimidazoles as Potent Negative Gating Modulators of Small Conductance Ca2+-Activated K+Channels

(2008) Ulrik S. Sørensen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a New Activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the Endothelium-Derived Hyperpolarizing Factor Response and Lowers Blood Pressure

(2008) A. Sankaranarayanan et al.   MOLECULAR PHARMACOLOGY