Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice

KCa3.1 channels maintain endothelium-dependent vasodilatation in isolated perfused kidneys of spontaneously hypertensive rats after chronic inhibition of NOS

(2012) Serge Simonet et al.   BRITISH JOURNAL OF PHARMACOLOGY

Defective Cx40 Maintains Cx37 Expression but Intact Cx40 Is Crucial for Conducted Dilations Irrespective of Hypertension

(2012) Alexander Jobs et al.   HYPERTENSION

Genetic KCa3.1-Deficiency Produces Locomotor Hyperactivity and Alterations in Cerebral Monoamine Levels

(2012) Kate Lykke Lambertsen et al.   PLoS One

Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs

(2011) Mads Damkjaer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Distinct Endothelium-Derived Hyperpolarizing Factors Emerge In Vitro and In Vivo and Are Mediated in Part via Connexin 40–Dependent Myoendothelial Coupling

(2011) Markus Boettcher et al.   HYPERTENSION

Opening of Small and Intermediate Calcium-Activated Potassium Channels Induces Relaxation Mainly Mediated by Nitric-Oxide Release in Large Arteries and Endothelium-Derived Hyperpolarizing Factor in Small Arteries from Rat

(2011) E. Stankevicius et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Amplification of EDHF-type vasodilatations in TRPC1-deficient mice

(2010) Kjestine Schmidt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

EDHF: spreading the influence of the endothelium

(2010) Christopher J Garland et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiac Small Conductance Ca 2+ -Activated K + Channel Subunits Form Heteromultimers via the Coiled-Coil Domains in the C Termini of the Channels

(2010) Dipika Tuteja et al.   CIRCULATION RESEARCH

Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease

(2010) Ralf Köhler et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Crucial importance of the endothelial K+ channel SK3 and connexin40 in arteriolar dilations during skeletal muscle contraction

(2010) Malte Milkau et al.   FASEB JOURNAL

Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension

(2010) Charlotte Wagner et al.   KIDNEY INTERNATIONAL

Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses

(2010) Cor de Wit et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Endothelium-derived hyperpolarising factors and associated pathways: a synopsis

(2010) Gillian Edwards et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery

(2009) Ivica Grgic et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo

(2009) Stephanie E. Wölfle et al.   CARDIOVASCULAR RESEARCH

Different pathways with distinct properties conduct dilations in the microcirculation in vivo

(2009) Cor de Wit   CARDIOVASCULAR RESEARCH

Genetic Deficit of SK3 and IK1 Channels Disrupts the Endothelium-Derived Hyperpolarizing Factor Vasodilator Pathway and Causes Hypertension

(2009) Sebastian Brähler et al.   CIRCULATION

Endothelial-Specific Deletion of Connexin40 Promotes Atherosclerosis by Increasing CD73-Dependent Leukocyte Adhesion

(2009) C.E. Chadjichristos et al.   CIRCULATION

EDHF: an update

(2009) Michel Félétou et al.   CLINICAL SCIENCE

Endothelium-dependent Vasodilation in Myogenically Active Mouse Skeletal Muscle Arterioles: Role of EDH and K+Channels

(2009) Simon J. Potocnik et al.   MICROCIRCULATION

The Myoendothelial Junction: Breaking through the Matrix?

(2009) Katherine R. Heberlein et al.   MICROCIRCULATION

Incidence of protein on actin bridges between endothelium and smooth muscle in arterioles demonstrates heterogeneous connexin expression and phosphorylation

(2008) Brant E. Isakson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation

(2008) Jian-zhong Sheng et al.   FASEB JOURNAL

Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension

(2008) Frank Schweda et al.   KIDNEY INTERNATIONAL

Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a New Activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the Endothelium-Derived Hyperpolarizing Factor Response and Lowers Blood Pressure

(2008) A. Sankaranarayanan et al.   MOLECULAR PHARMACOLOGY

Functional Roles of a Ca 2+ -Activated K + Channel in Atrioventricular Nodes

(2007) Qian Zhang et al.   CIRCULATION RESEARCH

Connexin-mimetic peptides dissociate electrotonic EDHF-type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery

(2004) Andrew T Chaytor et al.   BRITISH JOURNAL OF PHARMACOLOGY