Trafficking of Intermediate (KCa3.1) and Small (KCa2.x) Conductance, Ca2+-Activated K+Channels: a Novel Target for Medicinal Chemistry Efforts?

Targeting SKCa Channels in Cancer: Potential New Therapeutic Approaches

(2012) A. Girault et al.   CURRENT MEDICINAL CHEMISTRY

Molecular Mechanisms of Ubiquitin-Dependent Membrane Traffic

(2011) James H. Hurley et al.   Annual Review of Biophysics

Small-Conductance Ca2+-Activated K+ Channels: Form and Function

(2011) John P. Adelman et al.   Annual Review of Physiology

Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs

(2011) Mads Damkjaer et al.   BRITISH JOURNAL OF PHARMACOLOGY

The lymphocyte potassium channels Kv1.3 and KCa3.1 as targets for immunosuppression

(2011) Jenny Lam et al.   DRUG DEVELOPMENT RESEARCH

A CAG repeat polymorphism ofKCNN3predicts SK3 channel function and cognitive performance in schizophrenia

(2011) Sabrina Grube et al.   EMBO Molecular Medicine

Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1

(2011) Corina M. Balut et al.   FASEB JOURNAL

Developmental profile of SK2 channel expression and function in CA1 neurons

(2011) Carmen Ballesteros-Merino et al.   HIPPOCAMPUS

Involvement of Dominant-negative Spliced Variants of the Intermediate Conductance Ca2+-activated K+Channel, KCa3.1, in Immune Function of Lymphoid Cells

(2011) Susumu Ohya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic redistribution of calcium sensitive potassium channels (hKCa3.1) in migrating cells

(2011) Albrecht Schwab et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SK2 Channels Are Neuroprotective for Ischemia-Induced Neuronal Cell Death

(2011) Duane Allen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of the Ca2+-Dependent K+ Channel, KCNN4/KCa3.1, Improves Tissue Protection and Locomotor Recovery after Spinal Cord Injury

(2011) D. Bouhy et al.   JOURNAL OF NEUROSCIENCE

Potential role of reduced basolateral potassium (IKCa3.1) channel expression in the pathogenesis of diarrhoea in ulcerative colitis

(2011) Adel Al-Hazza et al.   JOURNAL OF PATHOLOGY

Negative Gating Modulation by (R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) Depends on Residues in the Inner Pore Vestibule: Pharmacological Evidence of Deep-Pore Gating of KCa2 Channels

(2011) D. P. Jenkins et al.   MOLECULAR PHARMACOLOGY

The SK2-long isoform directs synaptic localization and function of SK2-containing channels

(2011) Duane Allen et al.   NATURE NEUROSCIENCE

Electrostatic influences of charged inner pore residues on the conductance and gating of small conductance Ca2+ activated K+ channels

(2011) W. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2 

(2011) X. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cloning and identification of tissue-specific expression of KCNN4 splice variants in rat colon

(2010) Christian Barmeyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ESCRT-dependent targeting of plasma membrane localized KCa3.1 to the lysosomes

(2010) Corina M. Balut et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Calcium-activated K+ channels increase cell proliferation independent of K+ conductance

(2010) Joanne E. Millership et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon

(2010) N. S. Nanda Kumar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Detrusor overactivity: an overview

(2010) Kiran Ashok et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Cardiac Small Conductance Ca 2+ -Activated K + Channel Subunits Form Heteromultimers via the Coiled-Coil Domains in the C Termini of the Channels

(2010) Dipika Tuteja et al.   CIRCULATION RESEARCH

Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease

(2010) Ralf Köhler et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Immunofluorescence-based assay to identify modulators of the number of plasma membrane KCa3.1 channels

(2010) Corina M Balut et al.   Future Medicinal Chemistry

Ion channel trafficking: A new therapeutic horizon for atrial fibrillation

(2010) Sarah M. Schumacher et al.   HEART RHYTHM

Nucleoside Diphosphate Kinase B Knock-out Mice Have Impaired Activation of the K+Channel KCa3.1, Resulting in Defective T Cell Activation

(2010) Lie Di et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recycling of the Ca2+-activated K+Channel, KCa2.3, Is Dependent upon RME-1, Rab35/EPI64C, and an N-terminal Domain

(2010) Yajuan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the PCMBS-dependent modification of KCa3.1 channel gating

(2010) Mark A. Bailey et al.   JOURNAL OF GENERAL PHYSIOLOGY

Coupled Activity-Dependent Trafficking of Synaptic SK2 Channels and AMPA Receptors

(2010) M. T. Lin et al.   JOURNAL OF NEUROSCIENCE

Correction of the  Phe508 Cystic Fibrosis Transmembrane Conductance Regulator Trafficking Defect by the Bioavailable Compound Glafenine

(2010) R. Robert et al.   MOLECULAR PHARMACOLOGY

Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice

(2010) Ralf Köhler et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Endothelium-derived hyperpolarising factors and associated pathways: a synopsis

(2010) Gillian Edwards et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ca2+-Activated K+ Channels: From Protein Complexes to Function

(2010) Henrike Berkefeld et al.   PHYSIOLOGICAL REVIEWS

Small conductance calcium-activated potassium channels: From structure to function

(2010) Kate L. Weatherall et al.   PROGRESS IN NEUROBIOLOGY

Therapeutic potential of KCa3.1 blockers: recent advances and promising trends

(2010) Heike Wulff et al.   Expert Review of Clinical Pharmacology

Molecular mechanisms underlying anorexia nervosa: Focus on human gene association studies and systems controlling food intake

(2009) Mathias Rask-Andersen et al.   BRAIN RESEARCH REVIEWS

The K+channels KCa3.1 and Kv1.3 as novel targets for asthma therapy

(2009) Peter Bradding et al.   BRITISH JOURNAL OF PHARMACOLOGY

Calcium-activated potassium channels and endothelial dysfunction: therapeutic options?

(2009) Michel Félétou   BRITISH JOURNAL OF PHARMACOLOGY

Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery

(2009) Ivica Grgic et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functions and Modulation of Neuronal SK Channels

(2009) E. S. Louise Faber   CELL BIOCHEMISTRY AND BIOPHYSICS

Antiarrhythmic Drug-Induced Internalization of the Atrial-Specific K + Channel Kv1.5

(2009) Sarah M. Schumacher et al.   CIRCULATION RESEARCH

EDHF: an update

(2009) Michel Félétou et al.   CLINICAL SCIENCE

Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic  -Cells

(2009) M. Dufer et al.   DIABETES

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Rapid endocytosis provides restricted somatic expression of a K+ channel in central neurons

(2009) S. A. L. Correa et al.   JOURNAL OF CELL SCIENCE

Role of K+ Channels in Regulating Spontaneous Activity in Detrusor Smooth Muscle In Situ in the Mouse Bladder

(2009) Masa Hayase et al.   JOURNAL OF UROLOGY

Antifibrillatory Agents and Potassium Channels in the Atria: Pore Block versus Channel Trafficking

(2009) D. P. McEwen et al.   MOLECULAR INTERVENTIONS

Selective Activation of the SK1 Subtype of Human Small-Conductance Ca2+-Activated K+ Channels by 4-(2-Methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic Acid tert-Butyl Ester (GW542573X) Is Dependent on Serine 293 in the S5 Segment

(2009) C. Hougaard et al.   MOLECULAR PHARMACOLOGY

Subcellular targeting strategies for drug design and delivery

(2009) Lawrence Rajendran et al.   NATURE REVIEWS DRUG DISCOVERY

Blockade of T-Lymphocyte KCa3.1 and Kv1.3 Channels as Novel Immunosuppression Strategy to Prevent Kidney Allograft Rejection

(2009) I. Grgic et al.   TRANSPLANTATION PROCEEDINGS

Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells

(2008) Hélène Klein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia

(2008) K. I. Ataga et al.   BLOOD

Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain

(2008) P. Pedarzani et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

K+Channel Modulators for the Treatment of Neurological Disorders and Autoimmune Diseases

(2008) Heike Wulff et al.   CHEMICAL REVIEWS

Hydrophobic Interactions as Key Determinants to the KCa3.1 Channel Closed Configuration

(2008) Line Garneau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of S3 and S4 Transmembrane Domain Charged Amino Acids in Channel Biogenesis and Gating of KCa2.3 and KCa3.1

(2008) Yajuan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Structure−Activity Relationship Studies of 2-(N-Substituted)-aminobenzimidazoles as Potent Negative Gating Modulators of Small Conductance Ca2+-Activated K+Channels

(2008) Ulrik S. Sørensen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala

(2008) E. S. L. Faber et al.   JOURNAL OF NEUROSCIENCE

KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease

(2008) Mamdouh Albaqumi et al.   KIDNEY INTERNATIONAL

Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a New Activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the Endothelium-Derived Hyperpolarizing Factor Response and Lowers Blood Pressure

(2008) A. Sankaranarayanan et al.   MOLECULAR PHARMACOLOGY

SK2 channel plasticity contributes to LTP at Schaffer collateral–CA1 synapses

(2008) Mike T Lin et al.   NATURE NEUROSCIENCE

Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1

(2008) S. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of methyl β-cyclodextrin on EDHF responses in pig and rat arteries; association between SKCa channels and caveolin-rich domains

(2007) M Absi et al.   BRITISH JOURNAL OF PHARMACOLOGY