Modulation of nociceptive ion channels and receptors via protein-protein interactions: implications for pain relief

GABA Blocks Pathological but Not Acute TRPV1 Pain Signals

(2015) Christina Hanack et al.   CELL

Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 – 2014)

(2015) Yoonji Lee et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Small Organic Molecule Disruptors of Cav3.2 - USP5 Interactions Reverse Inflammatory and Neuropathic Pain

(2015) Vinicius M Gadotti et al.   Molecular Pain

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain

(2015) Hao-Jui Weng et al.   NEURON

Down-regulation of Stargazin Inhibits the Enhanced Surface Delivery of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate Receptor GluR1 Subunit in Rat Dorsal Horn and Ameliorates Postoperative Pain

(2014) Ruijuan Guo et al.   ANESTHESIOLOGY

Spatiotemporal Changes in NSF Expression of DRG Neurons in a Rat Model of Spinal Nerve Ligation

(2014) Xiang Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Annexin A2 Regulates TRPA1-Dependent Nociception

(2014) L. Avenali et al.   JOURNAL OF NEUROSCIENCE

Painful and painless channelopathies

(2014) David L H Bennett et al.   LANCET NEUROLOGY

The Deubiquitinating Enzyme USP5 Modulates Neuropathic and Inflammatory Pain by Enhancing Cav3.2 Channel Activity

(2014) Agustin García-Caballero et al.   NEURON

Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction

(2014) Brett A. Simms et al.   NEURON

The pain interactome: Connecting pain-specific protein interactions

(2014) Daniel G. Jamieson et al.   PAIN

Direct evidence for functional TRPV1/TRPA1 heteromers

(2014) Michael J. M. Fischer et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Calcium-Permeable Ion Channels in Pain Signaling

(2014) Emmanuel Bourinet et al.   PHYSIOLOGICAL REVIEWS

Advances in voltage-gated calcium channel structure, function and physiology

(2013) Gerald W. Zamponi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Reversal of Neuropathic Pain in Diabetes by Targeting Glycosylation of Cav3.2 T-Type Calcium Channels

(2013) P. Orestes et al.   DIABETES

Disrupting Sensitization of Transient Receptor Potential Vanilloid Subtype 1 Inhibits Inflammatory Hyperalgesia

(2013) M. J. M. Fischer et al.   JOURNAL OF NEUROSCIENCE

Combination pharmacotherapy for management of chronic pain: from bench to bedside

(2013) Ian Gilron et al.   LANCET NEUROLOGY

Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system

(2013) Ben C Collins et al.   NATURE METHODS

Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides

(2013) Polina Feldman et al.   NEUROSCIENCE LETTERS

Targeting protein–protein interactions as an anticancer strategy

(2013) Andrei A. Ivanov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

TRPA1: A Gatekeeper for Inflammation

(2012) Diana M. Bautista et al.   Annual Review of Physiology

Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture

(2012) Janek Hendrich et al.   Channels

From mouse to humans: discovery of the CACNG2 pain susceptibility gene

(2012) J Nissenbaum   CLINICAL GENETICS

Phosphorylation-Dependent Protein-Protein Interaction Modules As Potential Molecular Targets for Cancer Therapy

(2012) Nobumoto Watanabe et al.   CURRENT DRUG TARGETS

Inhibition of Transmitter Release and Attenuation of Anti-retroviral-associated and Tibial Nerve Injury-related Painful Peripheral Neuropathy by Novel Synthetic Ca2+Channel Peptides

(2012) Sarah M. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRMP-2 Peptide Mediated Decrease of High and Low Voltage-Activated Calcium Channels, Attenuation of Nociceptor Excitability, and Anti-Nociception in a Model of AIDS Therapy-Induced Painful Peripheral Neuropathy

(2012) Andrew D Piekarz et al.   Molecular Pain

Protein–protein interaction inhibitors get into the groove

(2012) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

TRIP Database 2.0: A Manually Curated Information Hub for Accessing TRP Channel Interaction Network

(2012) Young-Cheul Shin et al.   PLoS One

Voltage-Gated Sodium Channels: Biophysics, Pharmacology, and Related Channelopathies

(2012) Eleonora Savio-Galimberti et al.   Frontiers in Pharmacology

Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca2+channel peptides

(2011) Giovanna Bucci et al.   JOURNAL OF PHYSIOLOGY-LONDON

Homer1a Signaling in the Amygdala Counteracts Pain-Related Synaptic Plasticity, mGluR1 Function and Pain Behaviors

(2011) Anke Tappe-Theodor et al.   Molecular Pain

Perturbing PSD-95 Interactions With NR2B-subtype Receptors Attenuates Spinal Nociceptive Plasticity and Neuropathic Pain

(2011) Richard D'Mello et al.   MOLECULAR THERAPY

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

(2011) Joel M Brittain et al.   NATURE MEDICINE

Pirt, a TRPV1 Modulator, Is Required for Histamine-Dependent and -Independent Itch

(2011) Kush N. Patel et al.   PLoS One

Calcium channel functions in pain processing

(2010) John Park et al.   Channels

Targeting protein–protein interactions for therapeutic intervention: a challenge for the future

(2010) Giovanna Zinzalla et al.   Future Medicinal Chemistry

Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2

(2010) J. Nissenbaum et al.   GENOME RESEARCH

Contribution of TRPV1-TRPA1 Interaction to the Single Channel Properties of the TRPA1 Channel

(2010) Alexander Staruschenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pain as a channelopathy

(2010) Ramin Raouf et al.   JOURNAL OF CLINICAL INVESTIGATION

Ziconotide for treatment of severe chronic pain

(2010) Achim Schmidtko et al.   LANCET

Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment

(2010) Ralf Baron et al.   LANCET NEUROLOGY

Regulation of AMPA Receptors in Spinal Nociception

(2010) Yun Wang et al.   Molecular Pain

Central mechanisms of pathological pain

(2010) Rohini Kuner   NATURE MEDICINE

Decoding signalling networks by mass spectrometry-based proteomics

(2010) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

Central sensitization: Implications for the diagnosis and treatment of pain

(2010) Clifford J. Woolf   PAIN

Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain

(2010) C. S. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ion channels and their molecular environments – Glimpses and insights from functional proteomics

(2010) Uwe Schulte et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

(2009) Michael Costigan et al.   Annual Review of Neuroscience

Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents

(2009) SK Florio et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1

(2009) Margaux M. Salas et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Aquaporin-1 Tunes Pain Perception by Interaction with Nav1.8 Na+Channels in Dorsal Root Ganglion Neurons

(2009) Hua Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Atypical Role for Collapsin Response Mediator Protein 2 (CRMP-2) in Neurotransmitter Release via Interaction with Presynaptic Voltage-gated Calcium Channels

(2009) Joel M. Brittain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons

(2009) X. X. Chi et al.   JOURNAL OF CELL SCIENCE

Persistent Inflammation Induces GluR2 Internalization via NMDA Receptor-Triggered PKC Activation in Dorsal Horn Neurons

(2009) J.-S. Park et al.   JOURNAL OF NEUROSCIENCE

The Increased Trafficking of the Calcium Channel Subunit  2 -1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the  2  Ligand Pregabalin

(2009) C. S. Bauer et al.   JOURNAL OF NEUROSCIENCE

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Shotgun Proteomics in Neuroscience

(2009) Lujian Liao et al.   NEURON

A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1

(2009) Nathaniel A. Jeske et al.   PAIN

Mechanisms of analgesia by gabapentin and pregabalin – Calcium channel α2-δ [Cavα2-δ] ligands

(2009) Charles P. Taylor   PAIN

SnapShot: Ion Channels and Pain

(2008) Patrick Delmas   CELL

Pirt, a Phosphoinositide-Binding Protein, Functions as a Regulatory Subunit of TRPV1

(2008) Andrew Y. Kim et al.   CELL

N-ethylmaleimide-sensitive fusion protein (NSF) is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation

(2008) Tayo Katano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Protein Kinase A Anchoring via AKAP150 Is Essential for TRPV1 Modulation by Forskolin and Prostaglandin E2 in Mouse Sensory Neurons

(2008) K. Schnizler et al.   JOURNAL OF NEUROSCIENCE

Cell-permeable Peptide Tat-PSD-95 PDZ2 Inhibits Chronic Inflammatory Pain Behaviors in Mice

(2008) Feng Tao et al.   MOLECULAR THERAPY

Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

(2008) Xue Jun Liu et al.   NATURE MEDICINE

Transient receptor potential channels: targeting pain at the source

(2008) Ardem Patapoutian et al.   NATURE REVIEWS DRUG DISCOVERY

Proinflammatory Mediators Modulate the Heat-Activated Ion Channel TRPV1 via the Scaffolding Protein AKAP79/150

(2008) Xuming Zhang et al.   NEURON

Small Molecule Protein–Protein Interaction Inhibitors as CNS Therapeutic Agents: Current Progress and Future Hurdles

(2008) Levi L Blazer et al.   NEUROPSYCHOPHARMACOLOGY

A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1

(2008) Nathaniel A. Jeske et al.   PAIN

Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat

(2007) Kristina S. Vikman et al.   JOURNAL OF PHYSIOLOGY-LONDON

Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors

(2007) Nikita B. Ruparel et al.   PAIN