Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 – 2014)

Unraveling structural mechanisms of allosteric drug action

(2014) Ruth Nussinov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Allosteric modulation of protein oligomerization: an emerging approach to drug design

(2014) Ronen Gabizon et al.   Frontiers in Chemistry

TRPV1: A Potential Drug Target for Treating Various Diseases

(2014) Rafael Brito et al.   Cells

Endogenous Modulators of TRP Channels

(2013) Enza Palazzo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Targeting TRP channels for pain relief

(2013) Jill-Desiree Brederson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Mapping the intramolecular signal transduction of G-protein coupled receptors

(2013) Yoonji Lee et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Targeting TRPV1 for pain relief: limits, losers and laurels

(2012) Arpad Szallasi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Multisteric TRPV1 nocisensor: a target for analgesics

(2012) János Szolcsányi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Transient receptor potential vanilloid type 1 and pain development

(2011) Enza Palazzo et al.   CURRENT OPINION IN PHARMACOLOGY

TRPV1 Signaling: Mechanistic Understanding and Therapeutic Potential

(2011) Rong Xia et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Hypothesis driven drug design: improving quality and effectiveness of the design-make-test-analyse cycle

(2011) Alleyn T. Plowright et al.   DRUG DISCOVERY TODAY

Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies

(2011) Jin Hee Lee et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Link between Allosteric Signal Transduction and Functional Dynamics in a Multisubunit Enzyme:S-Adenosylhomocysteine Hydrolase

(2011) Yoonji Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allostery in pharmacology: Thermodynamics, evolution and design

(2011) Gábor Maksay   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Transient receptor potential vanilloid-1 antagonists: a survey of recent patent literature

(2010) Eric A Voight et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Moving towards Supraspinal TRPV1 Receptors for Chronic Pain Relief

(2010) Enza Palazzo et al.   Molecular Pain

Pain market

(2010) Irena Melnikova   NATURE REVIEWS DRUG DISCOVERY

Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews

(2009) Kurt Kroenke et al.   GENERAL HOSPITAL PSYCHIATRY

Use of sensory methods for detecting target engagement in clinical trials of new analgesics

(2009) Boris A. Chizh et al.   Neurotherapeutics

Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks

(2008) Gilbert Y. Wong et al.   BRAIN RESEARCH REVIEWS

TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1

(2008) Stuart J. Conway   CHEMICAL SOCIETY REVIEWS

Antihyperalgesic Effects of (R,E)-N-(2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a Novel Transient Receptor Potential Vanilloid Type 1 Modulator That Does Not Cause Hyperthermia in Rats

(2008) S. G. Lehto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS