Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer

Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp.

(2022) Xuan Hong et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

(2022) Wenjing Xiao et al.   Autophagy

Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis

(2022) Simin Qi et al.   Molecular Cancer

STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response

(2022) Mehrdokht Sadrkhanloo et al.   PHARMACOLOGICAL RESEARCH

Zinc Dependent Regulation of ZEB1 and YAP1 Co-activation Promotes EMT Plasticity and Metastasis in Pancreatic Cancer

(2021) Mingyang Liu et al.   GASTROENTEROLOGY

p-MEK expression predicts prognosis of patients with adenocarcinoma of esophagogastric junction (AEG) and plays a role in anti-AEG efficacy of Huaier

(2021) Li Yuan et al.   PHARMACOLOGICAL RESEARCH

Natural product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer

(2021) Qiu‐Rui He et al.   BRITISH JOURNAL OF PHARMACOLOGY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The STAT3-MYC Axis Promotes Survival of Leukemia Stem Cells by Regulating SLC1A5 and Oxidative Phosphorylation

(2021) Maria Amaya et al.   BLOOD

Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer

(2021) Chunfeng Xie et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation

(2021) Jinyun Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

SLC-30A9 is required for Zn2+ homeostasis, Zn2+ mobilization, and mitochondrial health

(2021) Huichao Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway

(2021) Hongyu Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma

(2021) Wanlu Du et al.   Cell Reports

Therapeutic targeting of “undruggable” MYC

(2021) Victor Llombart et al.   EBioMedicine

Complement C3 overexpression activates JAK2/STAT3 pathway and correlates with gastric cancer progression

(2020) Kaitao Yuan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Target gene-independent functions of MYC oncoproteins

(2020) Apoorva Baluapuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Penicilazaphilone C, a New Azaphilone, Induces Apoptosis in Gastric Cancer by Blocking the Notch Signaling Pathway

(2020) Ming Wang et al.   Frontiers in Oncology

Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7

(2020) Weiyi Wang et al.   JOURNAL OF NATURAL PRODUCTS

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

(2020) Uddalak Bharadwaj et al.   PHARMACOLOGICAL REVIEWS

Aspeterreurone A, a Cytotoxic Dihydrobenzofuran–Phenyl Acrylate Hybrid from the Deep-Sea-Derived Fungus Aspergillus terreus CC-S06-18

(2020) Weiyi Wang et al.   JOURNAL OF NATURAL PRODUCTS

STAT3: A key signaling molecule for converting cold to hot tumors

(2020) Rui Hu et al.   CANCER LETTERS

The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis

(2020) Thirayost Nimmanon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting STAT3 in Cancer Immunotherapy

(2020) Sailan Zou et al.   Molecular Cancer

Myeloid cell–targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell–mediated immunity

(2020) Dayson Moreira et al.   JOURNAL OF CLINICAL INVESTIGATION

STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review

(2019) Jiang-Jiang Qin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

(2019) Longchuan Bai et al.   CANCER CELL

Exosomal lncRNA ZFAS1 regulates esophageal squamous cell carcinoma cell proliferation, invasion, migration and apoptosis via microRNA-124/STAT3 axis

(2019) Zhirong Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Revisiting the development of small molecular inhibitors that directly target the signal transducer and activator of transcription 3 (STAT3) domains

(2019) Po-Chang Shih   LIFE SCIENCES

The epithelial zinc transporter ZIP10 epigenetically regulates human epidermal homeostasis by modulating histone acetyltransferase activity

(2018) B.-H. Bin et al.   BRITISH JOURNAL OF DERMATOLOGY

STAT3 signaling drives EZH2 transcriptional activation and mediates poor prognosis in gastric cancer

(2016) Yuan-Ming Pan et al.   Molecular Cancer

Antibody-targeted drugs and drug resistance—Challenges and solutions

(2015) LeeRon Shefet-Carasso et al.   DRUG RESISTANCE UPDATES

Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid Tumors

(2015) Do-Youn Oh et al.   Cancer Research and Treatment

Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development

(2014) T. Miyai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors

(2010) Loana Musso et al.   BIOORGANIC & MEDICINAL CHEMISTRY