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Oncology
Yu-Xin Liao, Ji-Yang Lv, Zi-Fei Zhou, Tian-Yang Xu, Dong Yang, Qiu-Ming Gao, Lin Fan, Guo-Dong Li, Hai-Yang Yu, Kai-Yuan Liu
Summary: This study demonstrated that inhibition of CXCR4 sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death, suggesting that targeting the CXCR4/autophagy axis may be a promising therapeutic strategy to overcome chemotherapy resistance in osteosarcoma.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
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Cell Biology
Yong Cui, Yong-Yong Dong
Summary: Researchers have found that ZCCHC12 is highly upregulated in osteosarcoma cells, promoting cell proliferation, tumor growth, migration, and epithelial-mesenchymal transition. In addition, ZCCHC12 exerts its oncogenic function in osteosarcoma cells by activating the PI3K/AKT pathway. Inhibition of this pathway limits the oncogenic function of ZCCHC12 in osteosarcoma cells.
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Cell Biology
Kexiang Zhang, Song Wu, Hongwei Wu, Li Liu, Jiahui Zhou
Summary: The study demonstrated that activation of Notch1 by doxycycline effectively suppressed cell proliferation and induced S phase arrest in osteosarcoma cells, while also triggering apoptosis and autophagy. Notch1 activation inhibited the PI3K/Akt/mTOR signaling pathway to induce apoptosis and autophagy.
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Biology
Suresh Mickymaray, Faiz Abdulaziz Alfaiz, Anand Paramasivam, Vishnu Priya Veeraraghavan, Nanthini Devi Periadurai, Krishna Mohan Surapaneni, Guangfeng Niu
Summary: The study demonstrated that Rhaponticin exhibited potent anticancer effects against human osteosarcoma cells, especially MG-63 cells, by inducing cytotoxicity, inhibiting cell growth, and inducing apoptosis through various biological mechanisms.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
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Biology
Chao Xu, Qinwen Ye, Chao Ye, Shaojun Liu
Summary: circACTR2 is down-regulated in pancreatic cancer cells and can reverse chemoresistance by inhibiting the PI3K/AKT signaling pathway through sponge miR-221-3p and upregulating PTEN expression.
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Biotechnology & Applied Microbiology
Junbao Yang, Weilong Ding, Xiangyu Wang, Yongsheng Xiang
Summary: REV7 is highly expressed in glioma tissues and plays a crucial role in the chemosensitivity of glioma cells by regulating proliferation, apoptosis, and sensitivity to chemotherapy through the phosphoinositide 3-kinase signaling pathway. Targeting DNA polymerase zeta via REV7 may improve the sensitivity of glioma cells to chemotherapy.
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Pharmacology & Pharmacy
Xiongjie Huang, Habu Jiwa, Jingtao Xu, Jun Zhang, Yanran Huang, Xiaoji Luo
Summary: This study investigated the effect of Genipin on osteosarcoma and its potential mechanism. The results showed that Genipin significantly inhibited the proliferation, migration, and invasion of osteosarcoma cells, and promoted apoptosis. Animal experiments confirmed the anti-tumor effect of Genipin in vivo. The mechanism may be related to the regulation of the PI3K/AKT signaling pathway.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Oncology
Kezhou Xia, Xinghan Huang, Yingchun Zhao, Isabelle Yang, Weichun Guo
Summary: This study reveals that SERPINH1 is upregulated and associated with poor prognosis in osteosarcoma. SERPINH1 promotes the proliferation, migration, and invasion of osteosarcoma cells, and stimulates the growth of osteosarcoma in vivo by activating the PI3K-Akt signaling pathway.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Ying Jin, Yamei Chen, Huarong Tang, Xiao Hu, Shawna M. Hubert, Qian Li, Dan Su, Haimiao Xu, Yun Fan, Xinmin Yu, Qixun Chen, Jinshi Liu, Wei Hong, Yujin Xu, Huan Deng, Dapeng Zhu, Pansong Li, Yuhua Gong, Xuefeng Xia, Carl M. Gay, Jianjun Zhang, Ming Chen
Summary: This study investigates treatment resistance mechanisms in small cell lung cancer (SCLC) by comparing the genotype and phenotype in tumor samples of treatment-resistant and treatment-sensitive SCLC. The results suggest that activation of the PI3K/AKT pathway may be a potential mechanism underlying therapeutic resistance of SCLC, and provides a possible approach to reverse resistance to chemo/radiotherapy.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Songjia Ni, Jianjun Li, Sujun Qiu, Yingming Xie, Kaiqin Gong, Yang Duan
Summary: The study revealed that KIF21B is upregulated in osteosarcoma and may regulate the proliferation and apoptosis of osteosarcoma cells through the PI3K/AKT pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhun Wei, Kezhou Xia, Di Zheng, Changtian Gong, Weichun Guo
Summary: This study demonstrated that overexpression of RILP inhibits proliferation and impairs metastasis in osteosarcoma cells by restraining the PI3K/AKT/mTOR signaling pathway and promoting autophagy. Grb10 was identified as a potential target of RILP in regulating the PI3K/AKT pathway. Targeting RILP may be a promising strategy for osteosarcoma treatment.
MOLECULAR MEDICINE
(2023)
Article
Oncology
Wacili Da, Lin Tao, Yue Zhu
Summary: This study demonstrates that CTAB inhibits the proliferation and metastasis of osteosarcoma cells, induces apoptosis through the PI3K/AKT signaling pathway, and does not inhibit the growth of human osteoblasts.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Oncology
Tong Wu, Zan Jiao, Yixuan Li, Xuan Su, Fan Yao, Jin Peng, Weichao Chen, Ankui Yang
Summary: High expression of HPRT1 is associated with poor prognosis and resistance to cisplatin in OSCC cells. It can promote resistance to cisplatin by activating the MMP1/PI3K/Akt axis. HPRT1 may serve as a potential prognostic biomarker and therapeutic target in OSCC.
Article
Oncology
Pengfei Su, Lin Jiang, Yingjing Zhang, Tian Yu, Weiming Kang, Yuqin Liu, Jianchun Yu
Summary: This study found that tumor-associated macrophages (TAMs) play an important role in chemoresistance in gastric cancer. Gastric cancer cells induce polarization of TAMs, leading to increased resistance to chemotherapy. Additionally, the protein CXCL5 produced by TAMs promotes chemoresistance by activating the PI3K/AKT/mTOR pathway. These findings have important implications for the treatment strategies of gastric cancer patients.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Hongcheng Luo, Tingzhuang Yi, Deyou Huang, Xiaoping Chen, Xu Li, Qianquan Wan, Haineng Huang, Huadong Huang, Hongyu Wei, Ye Song, Tianshi Que, Rentong Hu, Huatuo Huang, Kunxiang Luo, Chuanyu Li, Chengjian Qin, Chuanhua Zheng, Chuanliu Lan, Wencheng Chen, Dan Zhou, Qisheng Luo
Summary: The study revealed that circ_PTN promotes DDP resistance in GBM cells through activating the PI3K/AKT pathway, with in vivo experiments demonstrating that circ_PTN silencing inhibits DDP resistance in GBM tumors.
MOLECULAR THERAPY NUCLEIC ACIDS
(2021)