The role of spexin in energy metabolism

Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior

(2022) Bora Jeong et al.   Biomolecules

Serum spexin levels are not associated with size at birth but are associated with metabolic syndrome components in prepubertal children born at term

(2022) Fatma Duygu Öztürk Önsal et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Treatment with spexin mitigates diet-induced hepatic steatosis in vivo and in vitro through activation of galanin receptor 2

(2022) Mengyuan Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effect of spexin on renal dysfunction in experimentally obese rats: potential mitigating mechanisms via galanin receptor-2

(2021) Mervat H. El-Saka et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Spexin ameliorates skeletal muscle insulin resistance through activation of GAL2 receptor

(2021) Mei Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

30-Day spexin treatment of mice with diet-induced obesity (DIO) and type 2 diabetes (T2DM) increases insulin sensitivity, improves liver functions and metabolic status

(2021) Pawel A. Kolodziejski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Spexin Promotes the Proliferation and Differentiation of C2C12 Cells In Vitro—The Effect of Exercise on SPX and SPX Receptor Expression in Skeletal Muscle In Vivo

(2021) Natalia Leciejewska et al.   Genes

Identification, tissue distribution, periprandial expression, and anorexigenic effect of spexin in Siberian sturgeon, Acipenser baeri

(2020) Zhengzhi Tian et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Short-term administration of spexin in rats reduces obesity by affecting lipolysis and lipogenesis: An in vivo and in vitro study

(2020) Ewa Pruszynska-Oszmalek et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Emerging Roles of NPQ/Spexin in Physiology and Pathology

(2019) Shuang-Yu Lv et al.   Frontiers in Pharmacology

Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction

(2019) Yang Liu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Supervised lifestyle intervention for people with metabolic syndrome improves outcomes and reduces individual risk factors of metabolic syndrome: A systematic review and meta-analysis

(2019) Maria van Namen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Roux en-Y gastric bypass surgery in youth with severe obesity: 1-year longitudinal changes in spexin

(2018) Seema Kumar et al.   Surgery for Obesity and Related Diseases

Spexin: A novel regulator of adipogenesis and fat tissue metabolism

(2018) Pawel A. Kolodziejski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Spexin Suppress Food Intake in Zebrafish: Evidence from Gene Knockout Study

(2017) Binbin Zheng et al.   Scientific Reports

Molecular cloning and functional characterization of spexin in orange-spotted grouper ( Epinephelus coioides )

(2016) Shuisheng Li et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Insulin Resistance Is Accompanied by Increased Fasting Glucagon and Delayed Glucagon Suppression in Individuals With Normal and Impaired Glucose Regulation

(2016) Kristine Færch et al.   DIABETES

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-alcoholic fatty liver disease and diabetes

(2016) Jonathan M. Hazlehurst et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Regulation of Hepatocellular Fatty Acid Uptake in Mouse Models of Fatty Liver Disease with and without Functional Leptin Signaling: Roles of NfKB and SREBP-1C and the Effects of Spexin

(2016) Jasmine Ge et al.   SEMINARS IN LIVER DISEASE

Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes

(2015) Liping Gu et al.   PEPTIDES

Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III

(2014) Dong-Kyu Kim et al.   ENDOCRINOLOGY

Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention

(2014) Yanling Wu et al.   International Journal of Medical Sciences

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity

(2014) José L. Walewski et al.   Obesity

Interactions between the central nervous system and pancreatic islet secretions: a historical perspective

(2013) Denovan P. Begg et al.   ADVANCES IN PHYSIOLOGY EDUCATION

Goldfish spexin: solution structure and novel function as a satiety factor in feeding control

(2013) Matthew K. H. Wong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus

(2013) Yun Liu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Galanin Receptors and Ligands

(2012) Kristin E. B. Webling et al.   Frontiers in Endocrinology

Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception

(2011) Lawrence Toll et al.   FASEB JOURNAL

Galanin receptor 3 - a potential target for acute pancreatitis therapy

(2011) S. G. Barreto et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Spexin Expression in Normal Rat Tissues

(2010) Andrea Porzionato et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Engineering Galanin Analogues That Discriminate between GalR1 and GalR2 Receptor Subtypes and Exhibit Anticonvulsant Activity following Systemic Delivery

(2010) Charles R. Robertson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expression of the spexin gene in the rat adrenal gland and evidences suggesting that spexin inhibits adrenocortical cell proliferation

(2010) Marcin Rucinski et al.   PEPTIDES

The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats

(2010) Belinda L. Ash et al.   REGULATORY PEPTIDES

C12ORF39, a novel secreted protein with a typical amidation processing signal

(2009) Bingbing Wan et al.   BIOSCIENCE REPORTS

The galanin receptor 2/3 agonist Gal2-11 protects the SN56 cells against β-amyloid25-35toxicity

(2009) S. Pirondi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Aspects of the hormonal regulation of appetite in fish with emphasis on goldfish, Atlantic cod and winter flounder: Notes on actions and responses to nutritional, environmental and reproductive changes

(2008) Hélène Volkoff et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Design, Synthesis, and Characterization of High-Affinity, Systemically-Active Galanin Analogues with Potent Anticonvulsant Activities

(2008) Grzegorz Bulaj et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential Role of Galanin Receptors in the Regulation of Depression-Like Behavior and Monoamine/Stress-Related Genes at the Cell Body Level

(2008) Eugenia Kuteeva et al.   NEUROPSYCHOPHARMACOLOGY