Diversified Synthesis of All-Carbon Quaternary gem-Difluorinated Cyclopropanes via Copper-Catalyzed Cross-Coupling

Copper-catalyzed radical relay in C(sp3)–H functionalization

(2022) Zuxiao Zhang et al.   CHEMICAL SOCIETY REVIEWS

Asymmetric Alkynylation of Tertiary Carbon‐Centered Radical via Copper‐Catalyzed Radical Relay

(2022) Dunqi Wu et al.   CHINESE JOURNAL OF CHEMISTRY

Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes

(2022) Fu-Li Wang et al.   Nature Chemistry

C–C Bond Forming Reactions Enabled by Vitamin B12─Opportunities and Challenges

(2022) Tomasz Wdowik et al.   ACS Catalysis

Control of Redox‐Active Ester Reactivity Enables a General Cross‐Electrophile Approach to Access Arylated Strained Rings**

(2022) Daniel C. Salgueiro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Diversification of gem‐Difluorocyclopropanes: Recent Advances and Challenges

(2022) Leiyang Lv et al.   ChemCatChem

Enantioselective Formation of All-Carbon Quaternary Stereocenters in gem-Difluorinated Cyclopropanes via Rhodium-Catalyzed Stereoablative Kinetic Resolution

(2022) Zhong-Tao Jiang et al.   ORGANIC LETTERS

Recent Advances on Transition-Metal Catalyzed Cross-Coupling Reactions of Gem-Difluorinated Cyclopropanes

(2022) Yulei Zhu et al.   SYNLETT

Tetrasubstituted Carbon Stereocenters via Copper-Catalyzed Asymmetric Sonogashira Coupling Reactions with Cyclic gem-Dihaloketones and Tertiary α-Carbonyl Bromides

(2022) Xueling Mo et al.   ACS Catalysis

Recent Developments in Copper(I)‐Catalyzed Enantioselective Alkynylation Reactions via a Radical Process

(2022) Xueling Mo et al.   CHINESE JOURNAL OF CHEMISTRY

Ligand Development for Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Racemic Alkyl Halides

(2022) Xiao-Yang Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium Hydride-Enabled Hydroalkenylation of Strained Molecules

(2022) Ziyan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of α‐Quaternary β‐Lactams via Copper‐Catalyzed Enantioconvergent Radical C(sp 3 )−C(sp 2 ) Cross‐Coupling with Organoboronate Esters

(2022) Fu‐Li Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium Catalyzed Regioselective C−H Allylation of Simple Arenes via C−C Bond Activation of Gem‐difluorinated Cyclopropanes

(2021) Zhong-Tao Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium‐Catalyzed Defluorinative Alkylation of gem ‐Difluorocyclopropanes: Switching Regioselectivity via Simple Hydrazones

(2021) Leiyang Lv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed Direct Allylation of Simple Arenes by Using Gem-Difluorinated Cyclopropanes as Allyl Surrogates

(2021) Ying Xia et al.   SYNLETT

Catalytic Enantioselective Ring-Opening Reactions of Cyclopropanes

(2020) Vincent Pirenne et al.   CHEMICAL REVIEWS

Selective Carbon–Carbon Bond Cleavage of Cyclopropylamine Derivatives

(2020) Olga O. Sokolova et al.   CHEMICAL REVIEWS

Creating Stereocenters within Acyclic Systems by C–C Bond Cleavage of Cyclopropanes

(2020) Yair Cohen et al.   CHEMICAL REVIEWS

Transition Metal-Catalyzed Selective Carbon–Carbon Bond Cleavage of Vinylcyclopropanes in Cycloaddition Reactions

(2020) Jianhua Wang et al.   CHEMICAL REVIEWS

The Cyclopropane Ring as a Reporter of Radical Leaving-Group Reactivity for Ni-Catalyzed C(sp3)–O Arylation

(2020) L. Reginald Mills et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysis by Visible Light Photoexcited Palladium Complexes

(2019) Vladimir Gevorgyan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trisulfur Radical Anion (S3•–) Involved [1 + 2 + 2] and [1 + 3 + 1] Cycloaddition with Aromatic Alkynes: Synthesis of Tetraphenylthiophene and 2-Benzylidenetetrahydrothiophene Derivatives

(2018) Jing-Hao Li et al.   ORGANIC LETTERS

Radical-Organometallic Hybrid Reaction System Enabling Couplings between Tertiary-Alkyl Groups and 1-Alkenyl Groups

(2018) Kimiaki Nakamura et al.   ACS Catalysis

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

(2018) Andrew Fensome et al.   JOURNAL OF MEDICINAL CHEMISTRY

Building C(sp3)-rich complexity by combining cycloaddition and C–C cross-coupling reactions

(2018) Tie–Gen Chen et al.   NATURE

The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

(2016) Tanaji T. Talele   JOURNAL OF MEDICINAL CHEMISTRY

Difluorocarbene Addition to Alkenes and Alkynes in Continuous Flow

(2016) Pauline Rullière et al.   ORGANIC LETTERS

Rhodium-Catalyzed [5 + 2 + 1] Cycloaddition of Ene–Vinylcyclopropanes and CO: Reaction Design, Development, Application in Natural Product Synthesis, and Inspiration for Developing New Reactions for Synthesis of Eight-Membered Carbocycles

(2015) Yi Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nickel-Catalyzed Suzuki-Miyaura Coupling of a Tertiary Iodocyclopropane with Wide Boronic Acid Substrate Scope: Coupling Reaction Outcome Depends on Radical Species Stability

(2015) Keisuke Yotsuji et al.   ADVANCED SYNTHESIS & CATALYSIS

Pd-Catalyzed Regioselective Activation ofgem-Difluorinated Cyclopropanes: A Highly Efficient Approach to 2-Fluorinated Allylic Scaffolds

(2015) Jun Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reaction between Azidyl Radicals and Alkynes: A Straightforward Approach to NH -1,2,3-Triazoles

(2015) Long Hu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo

(2015) Jason D. Burch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in homogeneous nickel catalysis

(2014) Sarah Z. Tasker et al.   NATURE

Synthesis ofgem-Difluorocyclopropa(e)nes and O-, S-, N-, and P-Difluoromethylated Compounds with TMSCF2Br

(2013) Lingchun Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Magical Power of Transition Metals: Past, Present, and Future (Nobel Lecture)

(2011) Ei-ichi Negishi   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of gem-Difluorinated Cyclopropanes and Cyclopropenes: Trifluoromethyltrimethylsilane as a Difluorocarbene Source

(2011) Fei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cross-Coupling Reactions Of Organoboranes: An Easy Way To Construct CC Bonds (Nobel Lecture)

(2011) Akira Suzuki   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION