Tetrasubstituted Carbon Stereocenters via Copper-Catalyzed Asymmetric Sonogashira Coupling Reactions with Cyclic gem-Dihaloketones and Tertiary α-Carbonyl Bromides

Investigation of the C–N Bond-Forming Step in a Photoinduced, Copper-Catalyzed Enantioconvergent N–Alkylation: Characterization and Application of a Stabilized Organic Radical as a Mechanistic Probe

(2022) Heejun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes

(2022) Fu-Li Wang et al.   Nature Chemistry

Quaternary stereocentres via catalytic enantioconvergent nucleophilic substitution reactions of tertiary alkyl halides

(2021) Zhaobin Wang et al.   Nature Chemistry

Iron‐Catalyzed Tertiary Alkylation of Terminal Alkynes with 1,3‐Diesters via a Functionalized Alkyl Radical

(2021) Ming‐Qing Tian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Asymmetric Deconstructive Alkynylation of Cyclic Oximes

(2021) Hang-Dong Zuo et al.   ACS Catalysis

Asymmetric Alkyl and Aryl/Azolation of Alkenes via a Single Cu(I) Complex

(2021) Xiaodong Ma et al.   ACS Catalysis

A Transient Directing Group Strategy Enables Enantioselective Multicomponent Organofluorine Synthesis

(2021) Zhonglin Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition‐Metal‐Catalyzed Monofluoroalkylation: Strategies for the Synthesis of Alkyl Fluorides by C−C Bond Formation

(2021) Trevor W. Butcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper‐Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α‐Bromoamides

(2020) Xueling Mo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Asymmetric Radical 1,2-Carboalkynylation of Alkenes with Alkyl Halides and Terminal Alkynes

(2020) Xiao-Yang Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium‐Catalyzed Regio‐, Diastereo‐, and Enantioselective 1,2‐Arylfluorination of Internal Enamides

(2020) Yang Xi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible‐Light‐Enabled Enantioconvergent Synthesis of α‐Amino Acid Derivatives via Synergistic Brønsted Acid/Photoredox Catalysis

(2020) Chao Che et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An enantioconvergent halogenophilic nucleophilic substitution (SN2X) reaction

(2019) Xin Zhang et al.   SCIENCE

Photoinduced, Copper-Catalyzed Radical Cross-Coupling of Cycloketone Oxime Esters, Alkenes, and Terminal Alkynes

(2019) Jun Chen et al.   ORGANIC LETTERS

Enantioselective construction of remote tertiary carbon–fluorine bonds

(2019) Jianbo Liu et al.   Nature Chemistry

A general asymmetric copper-catalysed Sonogashira C(sp3)–C(sp) coupling

(2019) Xiao-Yang Dong et al.   Nature Chemistry

Dianionic Phase-Transfer Catalyst for Asymmetric Fluoro-cyclization

(2018) Hiromichi Egami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formal enantioconvergent substitution of alkyl halides via catalytic asymmetric photoredox radical coupling

(2018) Jiangtao Li et al.   Nature Communications

Enantioselective Synthesis of Tertiary Allylic Fluorides by Iridium-Catalyzed Allylic Fluoroalkylation

(2018) Trevor W. Butcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quaternary stereocentres via an enantioconvergent catalytic SN1 reaction

(2018) Alison E. Wendlandt et al.   NATURE

Catalytic enantioconvergent coupling of secondary and tertiary electrophiles with olefins

(2018) Zhaobin Wang et al.   NATURE

Palladium-Catalyzed, Enantioselective α-Arylation of α-Fluorooxindoles

(2017) Yushu Jin et al.   ORGANIC LETTERS

Copper-Catalyzed Functionalized Tertiary-Alkylative Sonogashira Type Couplings via Copper Acetylide at Room Temperature

(2017) Yu Yamane et al.   ACS Catalysis

Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives

(2016) Javier Miró et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Cu-Catalyzed Stereoselective γ-Alkylation of Enones

(2016) Xiaohong Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Enantioselective α-Arylation of α-Fluoroketones

(2016) Zhiwei Jiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric copper-catalyzed C-N cross-couplings induced by visible light

(2016) Q. M. Kainz et al.   SCIENCE

Assembly of Fluorinated Quaternary Stereogenic Centers through Catalytic Enantioselective Detrifluoroacetylative Aldol Reactions

(2015) Chen Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoinduced Copper-Catalyzed Regioselective Synthesis of Indoles: Three-Component Coupling of Arylamines, Terminal Alkynes, and Quinones

(2015) Arunachalam Sagadevan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Palladium-Catalyzed Enantioselective 1,1-Fluoroarylation of Aminoalkenes

(2015) Ying He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Luminescent Ce(III) Complexes as Stoichiometric and Catalytic Photoreductants for Halogen Atom Abstraction Reactions

(2015) Haolin Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Fluorocyclizations of Alkenes

(2014) Jamie R. Wolstenhulme et al.   ACCOUNTS OF CHEMICAL RESEARCH

Copper-Catalyzed 1,2-Addition of α-Carbonyl Iodides to Alkynes

(2014) Tao Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

(2014) Xiaoyu Yang et al.   CHEMICAL REVIEWS

Successful fluorine-containing herbicide agrochemicals

(2014) Tomoya Fujiwara et al.   JOURNAL OF FLUORINE CHEMISTRY

Recent advances in the trifluoromethylation methodology and new CF3-containing drugs

(2014) Wei Zhu et al.   JOURNAL OF FLUORINE CHEMISTRY

Catalytic Asymmetric Synthesis of Tertiary Alkyl Fluorides: Negishi Cross-Couplings of Racemic α,α-Dihaloketones

(2014) Yufan Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Palladium-Catalyzed Directed Intermolecular Fluoroarylation of Styrenes

(2014) Eric P. A. Talbot et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic enantioselective synthesis of quaternary carbon stereocentres

(2014) Kyle W. Quasdorf et al.   NATURE

Enantioselective Fluoroamination: 1,4-Addition to Conjugated Dienes Using Anionic Phase-Transfer Catalysis

(2013) Hunter P. Shunatona et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of 3-Fluoro-3-aryl Oxindoles: Direct Enantioselective α Arylation of Amides

(2012) Linglin Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engaging unactivated alkyl, alkenyl and aryl iodides in visible-light-mediated free radical reactions

(2012) John D. Nguyen et al.   Nature Chemistry

Organocatalyzed Enantioselective Fluorocyclizations

(2011) Oscar Lozano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Electrophilic Fluorination Using an Anionic Chiral Phase-Transfer Catalyst

(2011) V. Rauniyar et al.   SCIENCE

Click-alkynylation of N- and P-nucleophiles by oxidative cross-coupling with alkynylcopper reagents: a general synthesis of ynamides and alkynylphosphonates

(2011) Kévin Jouvin et al.   Chemical Science

Estimation of Standard Reduction Potentials of Halogen Atoms and Alkyl Halides

(2010) Abdirisak A. Isse et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Asymmetric Mannich Reaction of Fluorinated Ketoesters with a Tryptophan-Derived Bifunctional Thiourea Catalyst

(2009) Xiao Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS