Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells

Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers

(2022) Wenzhi Song et al.   IMMUNITY

Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity

(2022) Katharina Lambert et al.   Science Translational Medicine

Excessive negative regulation of type I interferon disrupts viral control in individuals with Down syndrome

(2022) Louise Malle et al.   IMMUNITY

A Streamlined Whole Blood CyTOF Workflow Defines A Circulating Immune Cell Signature of COVID ‐19

(2021) Daniel Geanon et al.   CYTOMETRY PART A

Dermatologic conditions in Down syndrome

(2021) Chenin Ryan et al.   PEDIATRIC DERMATOLOGY

The expansion of human T-bet high CD21 low B cells is T cell dependent

(2021) Baerbel Keller et al.   Science Immunology

Down syndrome

(2020) Stylianos E. Antonarakis et al.   Nature Reviews Disease Primers

Immune Defect in Adults With Down Syndrome: Insights Into a Complex Issue

(2020) Yannick Dieudonné et al.   Frontiers in Immunology

Inborn Errors of Adaptive Immunity in Down Syndrome

(2020) Ruud H.J. Verstegen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome

(2020) Xiao-Fei Kong et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Down Syndrome

(2020) Marilyn J. Bull   NEW ENGLAND JOURNAL OF MEDICINE

Individuals with Down syndrome hospitalized with COVID-19 have more severe disease

(2020) Louise Malle et al.   GENETICS IN MEDICINE

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

(2020) Matthew C. Woodruff et al.   NATURE IMMUNOLOGY

Clinical aspects of STAT3 gain-of-function germline mutations: A Systematic Review

(2019) Alexandre Fabre et al.   Journal of Allergy and Clinical Immunology-In Practice

T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells

(2019) Sara L. Stone et al.   IMMUNITY

IFNγ induces epigenetic programming of human T-bethi B cells and promotesTLR7/8 and IL-21 induced differentiation

(2019) Esther Zumaquero et al.   eLife

Analysis of the B cell receptor repertoire in six immune-mediated diseases

(2019) R. J. M. Bashford-Rogers et al.   NATURE

Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity

(2019) Paula Araya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

National population‐based estimates for major birth defects, 2010–2014

(2019) Cara T. Mai et al.   Birth Defects Research

Increased systemic inflammation in children with Down syndrome

(2019) Dean Huggard et al.   CYTOKINE

Understanding B-cell activation and autoantibody repertoire selection in systemic lupus erythematosus: A B-cell immunomics approach

(2018) Christopher M. Tipton et al.   IMMUNOLOGICAL REVIEWS

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

(2018) Shu Wang et al.   Nature Communications

Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes

(2018) Ilkka S. Junttila   Frontiers in Immunology

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

(2018) Irene Maeve Rea et al.   Frontiers in Immunology

Immunotherapy in selected patients with Down syndrome disintegrative disorder

(2018) Kathleen M Cardinale et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

The Goldilocks Zone of Type I IFNs: Lessons from Human Genetics

(2018) Justin Taft et al.   JOURNAL OF IMMUNOLOGY

Characterization of Thyroid Abnormalities in a Large Cohort of Children with Down Syndrome


(2017) Melinda J. Pierce et al.   Hormone Research in Paediatrics

Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis

(2017) Yan Zhang et al.   Oncotarget

The Role of Brain-Reactive Autoantibodies in Brain Pathology and Cognitive Impairment

(2017) Simone Mader et al.   Frontiers in Immunology

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Fc Receptor–like 5 Expression Distinguishes Two Distinct Subsets of Human Circulating Tissue–like Memory B Cells

(2016) Huifang Li et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells

(2016) Martin S. Naradikian et al.   JOURNAL OF IMMUNOLOGY

Trisomy 21 consistently activates the interferon response

(2016) Kelly D Sullivan et al.   eLife

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

The Chemokine System in Innate Immunity

(2015) Caroline L. Sokol et al.   Cold Spring Harbor Perspectives in Biology

FactoMineR: AnRPackage for Multivariate Analysis

(2015) Sébastien Lê et al.   Journal of Statistical Software

Defective B-cell memory in patients with Down syndrome

(2014) Ruud H.J. Verstegen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autoimmune Predisposition in Down Syndrome May Result from a Partial Central Tolerance Failure due to Insufficient Intrathymic Expression ofAIREand Peripheral Antigens

(2014) Mireia Giménez-Barcons et al.   JOURNAL OF IMMUNOLOGY

Mendelian susceptibility to mycobacterial disease: Genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

(2014) Jacinta Bustamante et al.   SEMINARS IN IMMUNOLOGY

Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4

(2013) Zamaneh Mikhak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular Basis of 9G4 B Cell Autoreactivity in Human Systemic Lupus Erythematosus

(2013) C. Richardson et al.   JOURNAL OF IMMUNOLOGY

Using synthetic templates to design an unbiased multiplex PCR assay

(2013) Christopher S. Carlson et al.   Nature Communications

Ultra-sensitive detection of rare T cell clones

(2011) Harlan Robins et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Functional Characteristics of the High Affinity IgG Receptor, Fc RI

(2011) C. E. van der Poel et al.   JOURNAL OF IMMUNOLOGY

Seromic profiling of ovarian and pancreatic cancer

(2010) S. Gnjatic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive assessment of T-cell receptor  -chain diversity in    T cells

(2009) H. S. Robins et al.   BLOOD

DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome

(2009) Aude-Marie Lepagnol-Bestel et al.   HUMAN MOLECULAR GENETICS