Dermatologic conditions in Down syndrome

Down syndrome (DS) is the most common chromosomal condition and affects many organs including the skin. Dermatologists are an integral part of the DS care team. This is a review of both common and rare dermatologic conditions in DS. We provide practical strategies for a successful dermatology interview and examination. We explore the downstream effects of trisomy of chromosome 21, in particular on the immune system, and how these insights may enhance our pathophysiologic understanding of their cutaneous conditions.

Automated summary

Down syndrome affects multiple organs including the skin, and dermatologists play a significant role in the care team. This review covers both common and rare dermatologic conditions in DS, providing practical strategies for successful dermatology interviews and examinations. The study explores the downstream effects of trisomy of chromosome 21 on the immune system, particularly in relation to cutaneous conditions.