Extracellular vesicles as markers and mediators of pregnancy complications: gestational diabetes, pre‐eclampsia, preterm birth and fetal growth restriction

Small extracellular vesicles from plasma of women with preeclampsia increase myogenic tone and decrease endothelium-dependent relaxation of mouse mesenteric arteries

(2022) Juliana S. Powell et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

The Role of Extracellular Vesicles in Embryo Implantation

(2022) Kaiyu Chen et al.   Frontiers in Endocrinology

Extracellular Vesicles—New Players in Cell-To-Cell Communication in Gestational Diabetes Mellitus

(2022) Carlos Palma et al.   Biomedicines

Extracellular vesicles and immune response during pregnancy: A balancing act*

(2022) Adrian E. Morelli et al.   IMMUNOLOGICAL REVIEWS

Watermelon‐derived extracellular vesicles influence human ex vivo placental cell behaviour by altering intestinal secretions

(2022) Kate Timms et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Extracellular Vesicles, Inflammation, and Cardiovascular Disease

(2022) Akbarshakh Akhmerov et al.   Cells

ODP434 Maternally-Derived Pancreatic Extracellular Vesicle Encompassed miRNAs Influence Placental Development in Pregnancies Complicated by Gestational Diabetes

(2022) Rachel Quilang et al.   Journal of the Endocrine Society

Extracellular vesicle interplay in cardiovascular pathophysiology

(2021) Sherin Saheera et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The endogenous exposome of the pregnant mother: Placental extracellular vesicles and their effect on the maternal system

(2021) Nadja Kupper et al.   MOLECULAR ASPECTS OF MEDICINE

Potential of extracellular vesicles in the Parkinson's disease – Pathological mediators and biomarkers

(2021) Yuan Zhao et al.   NEUROCHEMISTRY INTERNATIONAL

Pregnancy-Related Extracellular Vesicles Revisited

(2021) Carmen Elena Condrat et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Extracellular Vesicles in Disease Progression and Detection of Hepatocellular Carcinoma

(2021) Yi-Te Lee et al.   Cancers

The Multifaceted Role of Extracellular Vesicles in Glioblastoma: microRNA Nanocarriers for Disease Progression and Gene Therapy

(2021) Natalia Simionescu et al.   Pharmaceutics

Disruption of the Blood-Brain Barrier by Extracellular Vesicles From Preeclampsia Plasma and Hypoxic Placentae: Attenuation by Magnesium Sulfate

(2021) José León et al.   HYPERTENSION

NF-κB regulation in maternal immunity during normal and IUGR pregnancies

(2021) Gaayathri Ariyakumar et al.   Scientific Reports

Development of placental abnormalities in location and anatomy – a narrative review

(2020) Charlotte H.J.R. Jansen et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Hypoxia-induced small extracellular vesicle proteins regulate proinflammatory cytokines and systemic blood pressure in pregnant rats

(2020) Suchismista Dutta et al.   CLINICAL SCIENCE

Protein Profile Changes in Circulating Placental Extracellular Vesicles in Term and Preterm Births: A Longitudinal Study

(2020) Ramkumar Menon et al.   ENDOCRINOLOGY

Unique microRNA Signals in Plasma Exosomes from Pregnancies Complicated by Preeclampsia

(2020) Hui Li et al.   HYPERTENSION

Towards a global consensus on GDM diagnosis: Light at the end of the tunnel?

(2020) Anil Kapur et al.   INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS

Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers

(2020) Pasquale Simeone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles in Feto–Maternal Crosstalk and Pregnancy Disorders

(2020) Danilo Buca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles in normal pregnancy and pregnancy‐related diseases

(2020) Jiayin Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Editorial: Causes and Consequences of Intrauterine Growth Restriction

(2020) Ivo Bendix et al.   Frontiers in Endocrinology

Fetal Exosomal Platelet-activating Factor Triggers Functional Progesterone Withdrawal in Human Placenta

(2020) Kristy T. Palomares et al.   Reproductive Sciences

Extracellular vesicles in Embryo Implantation and Disorders of the Endometrium

(2020) Anuradha Mishra et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Lipidomic Biomarkers of Extracellular Vesicles for the Prediction of Preterm Birth in the Early Second Trimester

(2020) Qianqian Zhao et al.   JOURNAL OF PROTEOME RESEARCH

Decidual mesenchymal stem/stromal cell-derived extracellular vesicles ameliorate endothelial cell proliferation, inflammation, and oxidative stress in a cell culture model of preeclampsia

(2020) Shixuan Zheng et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Cargo small non-coding RNAs of extracellular vesicles isolated from uterine fluid associate with endometrial receptivity and implantation success

(2020) Tiantian Li et al.   FERTILITY AND STERILITY

miR-15b-5p promotes expression of proinflammatory cytokines in human placenta by inhibiting Apelin signaling pathway

(2020) Stacy M. Yadava et al.   PLACENTA

Extracellular Vesicles and Biomaterial Design: New Therapies for Cardiac Repair

(2020) Chloé Pezzana et al.   TRENDS IN MOLECULAR MEDICINE

Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact

(2019) Atul Malhotra et al.   Frontiers in Endocrinology

Exosomes Cause Preterm Birth in Mice: Evidence for Paracrine Signaling in Pregnancy

(2019) Samantha Sheller-Miller et al.   Scientific Reports

Circulating microparticle proteins obtained in the late first trimester predict spontaneous preterm birth at less than 35 weeks’ gestation: a panel validation with specific characterization by parity

(2019) Thomas F. McElrath et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Extracellular Vesicles in Human Oogenesis and Implantation

(2019) Francesca Andronico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA Profiles in Extracellular Vesicles From Serum Early in Pregnancies Complicated by Gestational Diabetes Mellitus

(2019) Virginie Gillet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Prediction of Gestational Hypertension, Preeclampsia and Fetal Growth Restriction via the First Trimester Screening of Plasma Exosomal C19MC microRNAs

(2019) Ilona Hromadnikova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pre-eclampsia: pathophysiology and clinical implications

(2019) Graham J Burton et al.   BMJ-British Medical Journal

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus

(2019) Neva Kandzija et al.   Journal of Extracellular Vesicles

Placenta-derived extracellular vesicles induce preeclampsia in mouse models

(2019) Cha Han et al.   HAEMATOLOGICA

In Vitro Human Implantation Model Reveals a Role for Endometrial Extracellular Vesicles in Embryo Implantation: Reprogramming the Cellular and Secreted Proteome Landscapes for Bidirectional Fetal‐Maternal Communication

(2019) Jemma Evans et al.   PROTEOMICS

Reconciling the distinct roles of angiogenic/anti-angiogenic factors in the placenta and maternal circulation of normal and pathological pregnancies

(2019) Anandita Umapathy et al.   ANGIOGENESIS

Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review

(2019) Daniele D’Arrigo et al.   Journal of Clinical Medicine

Building consensus and standards in fetal growth restriction studies

(2018) Sanne Jehanne Gordijn et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Maternal and umbilical cord serum–derived exosomes enhance endothelial cell proliferation and migration

(2018) Linyan Jia et al.   FASEB JOURNAL

Immune Cells at the Fetomaternal Interface: How the Microenvironment Modulates Immune Cells To Foster Fetal Development

(2018) Anne Schumacher et al.   JOURNAL OF IMMUNOLOGY

Foetoplacental communication via extracellular vesicles in normal pregnancy and preeclampsia

(2018) Delia I. Chiarello et al.   MOLECULAR ASPECTS OF MEDICINE

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth

(2018) Jezid Miranda et al.   PLACENTA

Is there a role for exosomes in foetoplacental endothelial dysfunction in gestational diabetes mellitus?

(2018) Tamara Sáez et al.   PLACENTA

Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine

(2018) Somayeh Keshtkar et al.   Stem Cell Research & Therapy

The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice

(2018) Mark A. Brown et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Adipose tissue exosomal proteomic profile reveals a role on placenta glucose metabolism in gestational diabetes mellitus

(2018) Nanthini Jayabalan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Distinct communication patterns of trophoblastic miRNA among the maternal-placental-fetal compartments

(2018) Alison G. Paquette et al.   PLACENTA

Extracellular vesicles: biomarkers and regulators of vascular function during extracorporeal circulation

(2018) Mark J. McVey et al.   Oncotarget

Human decidua basalis mesenchymal stem/stromal cells protect endothelial cell functions from oxidative stress induced by hydrogen peroxide and monocytes

(2018) M. A. Alshabibi et al.   Stem Cell Research & Therapy

Expression and trafficking of placental microRNAs at the feto-maternal interface

(2017) Guojing Chang et al.   FASEB JOURNAL

Placental Nano-vesicles Target to Specific Organs and Modulate Vascular Tone In Vivo

(2017) Mancy Tong et al.   HUMAN REPRODUCTION

Serum and exosomal miR-122 and miR-199a as a biomarker to predict therapeutic efficacy of hepatitis C patients

(2017) Xiaoyang Jiao et al.   JOURNAL OF MEDICAL VIROLOGY

Gestational Diabetes

(2017) Lynn R. Mack et al.   OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA

Influence of maternal BMI on the exosomal profile during gestation and their role on maternal systemic inflammation

(2017) Omar Elfeky et al.   PLACENTA

Syncytiotrophoblast extracellular vesicles – Circulating biopsies reflecting placental health

(2017) Dionne Tannetta et al.   PLACENTA

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Placenta-derived extracellular vesicles: their cargo and possible functions

(2017) Mary Familari et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Procoagulant extracellular vesicles in amniotic fluid

(2017) Lena Hell et al.   Translational Research

First Characterization of Human Amniotic Fluid Stem Cell Extracellular Vesicles as a Powerful Paracrine Tool Endowed with Regenerative Potential

(2017) Carolina Balbi et al.   Stem Cells Translational Medicine

Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells – Liquid biopsies for monitoring complications of pregnancy

(2017) Grace Truong et al.   PLoS One

Secretome of in vitro cultured human embryos contains extracellular vesicles that are uptaken by the maternal side

(2017) Elisa Giacomini et al.   Scientific Reports

Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts

(2016) S. Kohli et al.   BLOOD

Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal-Placental Messaging

(2016) Beth Holder et al.   TRAFFIC

Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Angiogenesis: Potencial Clinical Application

(2016) Consuelo Merino-González et al.   Frontiers in Physiology

Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation

(2015) Carlos Salomon et al.   DIABETES

Exosome bound microRNAs transcriptionally regulate embryo-endometrial dialogue impacting implantation potential for AMA patients

(2015) A.L. Patton et al.   FERTILITY AND STERILITY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Oxygen tension regulates glucose-induced biogenesis and release of different subpopulations of exosome vesicles from trophoblast cells: A gestational age profile of placental exosomes in maternal plasma with gestational diabetes mellitus

(2015) Carlos Salomon et al.   PLACENTA

Placental Extracellular Vesicles and Feto-Maternal Communication

(2015) M. Tong et al.   Cold Spring Harbor Perspectives in Medicine

Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration

(2014) N. Arraud et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

miRNA in Plasma Exosome is Stable under Different Storage Conditions

(2014) Qinyu Ge et al.   MOLECULES

A Gestational Profile of Placental Exosomes in Maternal Plasma and Their Effects on Endothelial Cell Migration

(2014) Carlos Salomon et al.   PLoS One

Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)

(2014) C. Lees et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration

(2014) Carlos Salomon et al.   Frontiers in Pharmacology

Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease

(2013) Sarka Lisonkova et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Intercellular Transport of MicroRNAs

(2013) Reinier A. Boon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

(2013) Asfar S. Azmi et al.   CANCER AND METASTASIS REVIEWS

Gestational Diabetes Mellitus

(2013) D. R. Coustan   CLINICAL CHEMISTRY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

How apoptotic cells aid in the removal of their own cold dead bodies

(2012) G Wickman et al.   CELL DEATH AND DIFFERENTIATION

Immune cell activation by trophoblast-derived microvesicles is mediated by syncytin 1

(2012) Beth S. Holder et al.   IMMUNOLOGY

Review: Does size matter? Placental debris and the pathophysiology of pre-eclampsia

(2012) C.W.G. Redman et al.   PLACENTA

Maternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function

(2012) Lynne K. Warrander et al.   PLoS One

Trophoblast-Derived Exosomes Mediate Monocyte Recruitment and Differentiation

(2010) Safinur Atay et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Remodelling at the maternal–fetal interface: relevance to human pregnancy disorders

(2010) Judith E Cartwright et al.   REPRODUCTION

Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: a comparison with late normal pregnancy

(2009) Paula J Williams et al.   REPRODUCTION

Placental Origins of Preeclampsia

(2008) Berthold Huppertz   HYPERTENSION

Epidemiology and causes of preterm birth

(2008) Robert L Goldenberg et al.   LANCET

Circulating Microparticles in Normal Pregnancy and Pre-Eclampsia

(2008) C.W.G. Redman et al.   PLACENTA