Exosomes Cause Preterm Birth in Mice: Evidence for Paracrine Signaling in Pregnancy

Intrauterine exosomes are required for bovine conceptus implantation

(2018) Kazuya Kusama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes

(2018) Haruta Mogami et al.   Scientific Reports

Is myometrial inflammation a cause or a consequence of term human labour?

(2017) Natasha Singh et al.   JOURNAL OF ENDOCRINOLOGY

Damage-Associated molecular pattern markers HMGB1 and cell-Free fetal telomere fragments in oxidative-Stressed amnion epithelial cell-Derived exosomes

(2017) Samantha Sheller-Miller et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Prostaglandin dehydrogenase is a target for successful induction of cervical ripening

(2017) Annavarapu Hari Kishore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Progesterone Receptor-A Transrepressive Activity in Myometrial Cells: Implications for the Control of Human Parturition

(2017) Bansari Patel et al.   Reproductive Sciences

Exosomes: Origins and Therapeutic Potential for Neurodegenerative Disease

(2017) Diana K. Sarko et al.   Frontiers in Neuroscience

Exosomes, an Unmasked Culprit in Neurodegenerative Diseases

(2017) Federico N. Soria et al.   Frontiers in Neuroscience

Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells – Liquid biopsies for monitoring complications of pregnancy

(2017) Grace Truong et al.   PLoS One

Material properties of mouse cervical tissue in normal gestation

(2016) Kyoko Yoshida et al.   Acta Biomaterialia

Placental membrane aging and HMGB1 signaling associated with human parturition

(2016) Ramkumar Menon et al.   Aging-US

Contributions to the dynamics of cervix remodeling prior to term and preterm birth†

(2016) Steven M. Yellon   BIOLOGY OF REPRODUCTION

A dynamical systems model of progesterone receptor interactions with inflammation in human parturition

(2016) Douglas Brubaker et al.   BMC Systems Biology

Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition

(2016) Ramkumar Menon et al.   HUMAN REPRODUCTION UPDATE

p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing

(2016) Wenbo Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential senescence in feto-maternal tissues during mouse pregnancy

(2016) Elizabeth A. Bonney et al.   PLACENTA

Human fetal membranes at term: Dead tissue or signalers of parturition?

(2016) Ramkumar Menon   PLACENTA

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

(2016) Laura Santangelo et al.   Cell Reports

Feto-Maternal Trafficking of Exosomes in Murine Pregnancy Models

(2016) Samantha Sheller-Miller et al.   Frontiers in Pharmacology

CDC Grand Rounds: Public Health Strategies to Prevent Preterm Birth

(2016) Carrie K. Shapiro-Mendoza et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Amnion-Epithelial-Cell-Derived Exosomes Demonstrate Physiologic State of Cell under Oxidative Stress

(2016) Samantha Sheller et al.   PLoS One

Chorioamniotic membrane senescence: a signal for parturition?

(2015) Faranak Behnia et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Specific Lipopolysaccharide Serotypes Induce Differential Maternal and Neonatal Inflammatory Responses in a Murine Model of Preterm Labor

(2015) Roberta Migale et al.   AMERICAN JOURNAL OF PATHOLOGY

The Effect of Simvastatin on Infection-Induced Inflammatory Response of Human Fetal Membranes

(2015) Sanmaan K. Basraon et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Intra-Amniotic Administration of HMGB1 Induces Spontaneous Preterm Labor and Birth

(2015) Nardhy Gomez-Lopez et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation

(2015) Carlos Salomon et al.   DIABETES

Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition

(2015) Lu Gao et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches

(2015) Natasa Zarovni et al.   METHODS

Crosstalk between monocytes and myometrial smooth muscle in culture generates synergistic pro-inflammatory cytokine production and enhances myocyte contraction, with effects opposed by progesterone

(2015) S.P. Rajagopal et al.   MOLECULAR HUMAN REPRODUCTION

A Cross-Species Analysis of Animal Models for the Investigation of Preterm Birth Mechanisms

(2015) Brian W. Nielsen et al.   Reproductive Sciences

Macrophage Gene Expression Associated with Remodeling of the Prepartum Rat Cervix: Microarray and Pathway Analyses

(2015) Abigail E. Dobyns et al.   PLoS One

Telomere Fragment Induced Amnion Cell Senescence: A Contributor to Parturition?

(2015) Jossimara Polettini et al.   PLoS One

Placenta-Derived Exosomes and Syncytiotrophoblast Microparticles and their Role in Human Reproduction: Immune Modulation for Pregnancy Success

(2014) Lucia Mincheva-Nilsson et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Transcriptomic Profiling of Human Choriodecidua During Term Labor: Inflammation as a Key Driver of Labor

(2014) Gillian L. Stephen et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Prevalence and Clinical Significance of Sterile Intra-amniotic Inflammation in Patients with Preterm Labor and Intact Membranes

(2014) Roberto Romero et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

A New Role for Monocytes in Modulating Myometrial Inflammation During Human Labor1

(2014) Khetsopon Srikhajon et al.   BIOLOGY OF REPRODUCTION

Immune cells in term and preterm labor

(2014) Nardhy Gomez-Lopez et al.   Cellular & Molecular Immunology

Inflammation, Infection and Preterm Birth

(2014) Juliana Burdet et al.   CURRENT PHARMACEUTICAL DESIGN

Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia

(2014) Amandine Vargas et al.   FASEB JOURNAL

Inhibition of infection-mediated preterm birth by administration of broad spectrum chemokine inhibitor in mice

(2014) Oksana Shynlova et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hyaluronan in cervical epithelia protects against infection-mediated preterm birth

(2014) Yucel Akgul et al.   JOURNAL OF CLINICAL INVESTIGATION

Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy

(2014) Suchismita Sarker et al.   Journal of Translational Medicine

A Gestational Profile of Placental Exosomes in Maternal Plasma and Their Effects on Endothelial Cell Migration

(2014) Carlos Salomon et al.   PLoS One

HMGB1 Promotes a p38MAPK Associated Non-Infectious Inflammatory Response Pathway in Human Fetal Membranes

(2014) Sarah Bredeson et al.   PLoS One

Preterm labor: One syndrome, many causes

(2014) R. Romero et al.   SCIENCE

The coagulation profile of preterm delivery

(2014) Anat Keren-Politansky et al.   THROMBOSIS RESEARCH

Oxidative Stress Damage as a Detrimental Factor in Preterm Birth Pathology

(2014) Ramkumar Menon   Frontiers in Immunology

Prostaglandins Are Essential for Cervical Ripening in LPS-Mediated Preterm Birth But Not Term or Antiprogestin-Driven Preterm Ripening

(2013) Brenda C. Timmons et al.   ENDOCRINOLOGY

Exosomes Secreted by Human Placenta Carry Functional Fas Ligand and TRAIL Molecules and Convey Apoptosis in Activated Immune Cells, Suggesting Exosome-Mediated Immune Privilege of the Fetus

(2013) A.-C. Stenqvist et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-Induced Changes in the Bioactivity of Cytotrophoblast-Derived Exosomes

(2013) Carlos Salomon et al.   PLoS One

Senescence of Primary Amniotic Cells via Oxidative DNA Damage

(2013) Ramkumar Menon et al.   PLoS One

Signaling Pathways in Exosomes Biogenesis, Secretion and Fate

(2013) Lorena Urbanelli et al.   Genes

Detecting Biochemical Changes in the Rodent Cervix During Pregnancy Using Raman Spectroscopy

(2012) Elizabeth Vargis et al.   ANNALS OF BIOMEDICAL ENGINEERING

Residency and Activation of Myeloid Cells During Remodeling of the Prepartum Murine Cervix1

(2012) Kimberly J. Payne et al.   BIOLOGY OF REPRODUCTION

Immunomodulatory molecules are released from the first trimester and term placenta via exosomes

(2012) S.K. Kshirsagar et al.   PLACENTA

Cervical remodeling in term and preterm birth: insights from an animal model

(2012) Mala Mahendroo   REPRODUCTION

Physiologic Uterine Inflammation and Labor Onset

(2012) Oksana Shynlova et al.   Reproductive Sciences

The entry of fetal and amniotic fluid components into the uterine vessel circulation leads to sterile inflammatory processes during parturition

(2012) Hiroshi Kobayashi   Frontiers in Immunology

Complement Activation Triggers Metalloproteinases Release Inducing Cervical Remodeling and Preterm Birth in Mice

(2011) Juan M. Gonzalez et al.   AMERICAN JOURNAL OF PATHOLOGY

Changes in coagulation and hemodynamics during pregnancy: a prospective longitudinal study of 58 cases

(2011) Chen Hui et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells

(2011) Safinur Atay et al.   EXPERIMENTAL CELL RESEARCH

MAPK and AP-1 proteins are increased in term pre-labour fetal membranes overlying the cervix: Regulation of enzymes involved in the degradation of fetal membranes

(2011) M. Lappas et al.   PLACENTA

Cervical Remodeling/Ripening at Term and Preterm Delivery: The Same Mechanism Initiated by Different Mediators and Different Effector Cells

(2011) Juan M. Gonzalez et al.   PLoS One

The Role of Placental Exosomes in Reproduction

(2010) Lucia Mincheva-Nilsson et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice

(2010) Yasushi Hirota et al.   JOURNAL OF CLINICAL INVESTIGATION

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY