Immune Cells at the Fetomaternal Interface: How the Microenvironment Modulates Immune Cells To Foster Fetal Development

Interferon-gamma inhibits seminal plasma induction of colony-stimulating factor 2 in mouse and human reproductive tract epithelial cells†

(2018) David J Sharkey et al.   BIOLOGY OF REPRODUCTION

Seminal plasma pro-inflammatory cytokines interferon-γ (IFNG) and C-X-C motif chemokine ligand 8 (CXCL8) fluctuate over time within men

(2017) David J. Sharkey et al.   HUMAN REPRODUCTION

An immunogenic phenotype in paternal antigen-specific CD8+ T cells at embryo implantation elicits later fetal loss in mice

(2017) Lachlan M Moldenhauer et al.   IMMUNOLOGY AND CELL BIOLOGY

Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction

(2017) Yukiko Tanaka et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Maternal effector T cells within decidua: The adaptive immune response to pregnancy?

(2017) D. Lissauer et al.   PLACENTA

Embryo implantation evolved from an ancestral inflammatory attachment reaction

(2017) Oliver W. Griffith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mixed signature of activation and dysfunction allows human decidual CD8+T cells to provide both tolerance and immunity

(2017) Anita van der Zwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chymase-producing cells of the innate immune system are required for decidual vascular remodeling and fetal growth

(2017) Nicole Meyer et al.   Scientific Reports

Reduced uterine perfusion pressure T-helper 17 cells cause pathophysiology associated with preeclampsia during pregnancy

(2016) Denise C. Cornelius et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

JEG-3 Trophoblast Cells Producing Human Chorionic Gonadotropin Promote Conversion of Human CD4+FOXP3− T Cells into CD4+FOXP3+ Regulatory T Cells and Foster T Cell Suppressive Activity1

(2016) Eileen Poloski et al.   BIOLOGY OF REPRODUCTION

Seminal fluid and fertility in women

(2016) Sarah A. Robertson et al.   FERTILITY AND STERILITY

Human macrophages induce CD4+ Foxp3+ regulatory T cells via binding and re-release of TGF-β

(2016) Angelika Schmidt et al.   IMMUNOLOGY AND CELL BIOLOGY

The possible role of virus-specific CD8 + memory T cells in decidual tissue

(2016) A. van Egmond et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy

(2016) Suchita Nadkarni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human monocytes undergo functional re-programming during differentiation to dendritic cell mediated by human extravillous trophoblasts

(2016) Lei Zhao et al.   Scientific Reports

Maternal and Fetal Mechanisms of B Cell Regulation during Pregnancy: Human Chorionic Gonadotropin Stimulates B Cells to Produce IL-10 While Alpha-Fetoprotein Drives Them into Apoptosis

(2016) Franziska Fettke et al.   Frontiers in Immunology

An increased population of regulatory T cells improves the pathophysiology of placental ischemia in a rat model of preeclampsia

(2015) Denise C. Cornelius et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

TLR4 Signaling Is a Major Mediator of the Female Tract Response to Seminal Fluid in Mice1

(2015) John E. Schjenken et al.   BIOLOGY OF REPRODUCTION

Progesterone promotes maternal-fetal tolerance by reducing human maternal T-cell polyfunctionality and inducing a specific cytokine profile

(2015) David Lissauer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CXCR3 blockade protects against Listeria monocytogenes infection–induced fetal wastage

(2015) Vandana Chaturvedi et al.   JOURNAL OF CLINICAL INVESTIGATION

VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast-maternal leukocyte interaction

(2015) Laura Fraccaroli et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Seminal CD38 is a pivotal regulator for fetomaternal tolerance

(2015) Byung-Ju Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes

(2015) Tamara Tilburgs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Cells in the Female Reproductive Tract

(2015) Sung Ki Lee et al.   Immune Network

Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts

(2014) Joseph C. Chen et al.   HUMAN REPRODUCTION

Evidence for a Selective Migration of Fetus-Specific CD4+CD25bright Regulatory T Cells from the Peripheral Blood to the Decidua in Human Pregnancy

(2014) T. Tilburgs et al.   JOURNAL OF IMMUNOLOGY

Ovarian Dendritic Cells Act as a Double-Edged Pro-Ovulatory and Anti-Inflammatory Sword

(2014) Adva Cohen-Fredarow et al.   MOLECULAR ENDOCRINOLOGY

Interaction of Decidual CD56+ NK with Trophoblast Cells during Normal Pregnancy and Recurrent Spontaneous Abortion at Early Term of Gestation

(2014) N. Sotnikova et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

New insights into HLA-G mediated tolerance

(2014) G. Amodio et al.   TISSUE ANTIGENS

CD4+Foxp3+ regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesions

(2014) M-Q Li et al.   Cell Death & Disease

Cutting Edge: IL-10-Producing Regulatory B Cells in Early Human Pregnancy

(2013) Luise Rolle et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Seminal Fluid and the Generation of Regulatory T Cells for Embryo Implantation

(2013) Sarah A. Robertson et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Distribution of decidual natural killer cells and macrophages in the neighbourhood of the trophoblast invasion front: a quantitative evaluation

(2013) C. Helige et al.   HUMAN REPRODUCTION

Macrophages regulate corpus luteum development during embryo implantation in mice

(2013) Alison S. Care et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF- : Guardian of T Cell Function

(2013) S. A. Oh et al.   JOURNAL OF IMMUNOLOGY

Human Chorionic Gonadotropin as a Central Regulator of Pregnancy Immune Tolerance

(2013) A. Schumacher et al.   JOURNAL OF IMMUNOLOGY

Mast cells rescue implantation defects caused by c-kit deficiency

(2013) K Woidacki et al.   Cell Death & Disease

Control of Uterine Microenvironment by Foxp3+ Cells Facilitates Embryo Implantation

(2013) Ana Teles et al.   Frontiers in Immunology

Altered Decidual DC-SIGN+ Antigen-Presenting Cells and Impaired Regulatory T-Cell Induction in Preeclampsia

(2012) Peter Hsu et al.   AMERICAN JOURNAL OF PATHOLOGY

In vivoMultiphoton Microscopy Technique to Reveal the Physiology of the Mouse Uterus

(2012) Ana C. Zenclussen et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

CXCR4+ Dendritic cells promote angiogenesis during embryo implantation in mice

(2012) Gabriela Barrientos et al.   ANGIOGENESIS

Imaging of Vascular Development in Early Mouse Decidua and Its Association with Leukocytes and Trophoblasts1

(2012) B. Anne Croy et al.   BIOLOGY OF REPRODUCTION

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

(2012) Robert M. Samstein et al.   CELL

HLA-G expressing DC-10 and CD4+ T cells accumulate in human decidua during pregnancy

(2012) Giada Amodio et al.   HUMAN IMMUNOLOGY

Disruption of maternal immune balance maintained by innate DC subsets results in spontaneous pregnancy loss in mice

(2012) Yasuyuki Negishi et al.   IMMUNOBIOLOGY

Seminal Fluid Induces Leukocyte Recruitment and Cytokine and Chemokine mRNA Expression in the Human Cervix after Coitus

(2012) D. J. Sharkey et al.   JOURNAL OF IMMUNOLOGY

TGF-  Mediates Proinflammatory Seminal Fluid Signaling in Human Cervical Epithelial Cells

(2012) D. J. Sharkey et al.   JOURNAL OF IMMUNOLOGY

Impaired decidual natural killer cell regulation of vascular remodelling in early human pregnancies with high uterine artery resistance

(2012) Rupsha Fraser et al.   JOURNAL OF PATHOLOGY

Expression of the T regulatory cell transcription factor FoxP3 in peri-implantation phase endometrium in infertile women with endometriosis

(2012) Shufang Chen et al.   Reproductive Biology and Endocrinology

Chemokine Gene Silencing in Decidual Stromal Cells Limits T Cell Access to the Maternal-Fetal Interface

(2012) P. Nancy et al.   SCIENCE

Modulation and Recruitment of Inducible Regulatory T Cells by First Trimester Trophoblast Cells

(2011) Rosanna Ramhorst et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Seminal Fluid Regulates Accumulation of FOXP3+ Regulatory T Cells in the Preimplantation Mouse Uterus Through Expanding the FOXP3+ Cell Pool and CCL19-Mediated Recruitment1

(2011) Leigh R. Guerin et al.   BIOLOGY OF REPRODUCTION

Cardiovascular Adaptations of Pregnancy in T and B Cell-Deficient Mice

(2011) S. D. Burke et al.   BIOLOGY OF REPRODUCTION

Foxp3+ Regulatory T Cell Expansion Required for Sustaining Pregnancy Compromises Host Defense against Prenatal Bacterial Pathogens

(2011) Jared H. Rowe et al.   Cell Host & Microbe

Prostaglandin E2 and T cells: friends or foes?

(2011) Vinatha Sreeramkumar et al.   IMMUNOLOGY AND CELL BIOLOGY

Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1

(2011) Elisa Tagliani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Two Unique Human Decidual Macrophage Populations

(2011) B. L. Houser et al.   JOURNAL OF IMMUNOLOGY

Decidualization and angiogenesis in early pregnancy: unravelling the functions of DC and NK cells

(2011) Sandra M. Blois et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Effect of menstrual cycle variation in female sex hormones on cellular immunity and regulation

(2011) Adriana Weinberg et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Human leukocyte antigen-G in the male reproductive system and in seminal plasma

(2011) M. H. Larsen et al.   MOLECULAR HUMAN REPRODUCTION

The Immunomodulatory Role of Syncytiotrophoblast Microvesicles

(2011) Jennifer Southcombe et al.   PLoS One

Conditional ablation of macrophages disrupts ovarian vasculature

(2011) Emily C Turner et al.   REPRODUCTION

Analysis of uterine gene expression in interleukin-15 knockout mice reveals uterine natural killer cells do not play a major role in decidualization and associated angiogenesis

(2011) Brent M Bany et al.   REPRODUCTION

Seminal plasma enhances and accelerates progesterone-induced decidualisation of human endometrial stromal cells

(2011) U. Doyle et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

ORIGINAL ARTICLE: The Persistence of Paternal Antigens in the Maternal Body is Involved in Regulatory T-Cell Expansion and Fetal-Maternal Tolerance in Murine Pregnancy

(2010) Maria Laura Zenclussen et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The Interface of the Immune and Reproductive Systems in the Ovary: Lessons Learned from the Corpus Luteum of Domestic Animal Models

(2010) Joy L. Pate et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Murine Trophoblast Cells Induce NK Cell Interferon-Gamma Production Through KLRK11

(2010) Leonidas N. Carayannopoulos et al.   BIOLOGY OF REPRODUCTION

Macrophage-Derived LIF and IL1B Regulate Alpha(1,2)Fucosyltransferase 2 (Fut2) Expression in Mouse Uterine Epithelial Cells During Early Pregnancy1

(2010) Melinda J. Jasper et al.   BIOLOGY OF REPRODUCTION

Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans

(2010) P.-F. Guo et al.   BLOOD

Progesterone Increases Systemic and Local Uterine Proportions of CD4+CD25+Treg Cells during Midterm Pregnancy in Mice

(2010) Guanping Mao et al.   ENDOCRINOLOGY

GM-CSF Is an Essential Regulator of T Cell Activation Competence in Uterine Dendritic Cells during Early Pregnancy in Mice

(2010) L. M. Moldenhauer et al.   JOURNAL OF IMMUNOLOGY

Fluctuation of Peripheral Blood T, B, and NK Cells during a Menstrual Cycle of Normal Healthy Women

(2010) S. Lee et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice

(2010) Tomoko Shima et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Reduced proportion of decidual DC-SIGN+ cells in human spontaneous abortion

(2010) I. Tirado-González et al.   PLACENTA

Inhibitory NK Receptor Recognition of HLA-G: Regulation by Contact Residues and by Cell Specific Expression at the Fetal-Maternal Interface

(2010) Tsufit Gonen-Gross et al.   PLoS One

Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance

(2010) D. A. Kahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the primary outcomes that result from deficient spiral arterial modification in pregnant mice

(2010) B. Anne Croy et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

ORIGINAL ARTICLE: Timed Sexual Intercourse Facilitates the Recruitment of Uterine CD56bright Natural Killer Cells in Women with Infertility

(2009) Hidetaka Kimura et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

ORIGINAL ARTICLE: Impact of Female Sex Hormones on the Maturation and Function of Human Dendritic Cells

(2009) Sabine E. Segerer et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Seminal Fluid Drives Expansion of the CD4+CD25+ T Regulatory Cell Pool and Induces Tolerance to Paternal Alloantigens in Mice1

(2009) Sarah A. Robertson et al.   BIOLOGY OF REPRODUCTION

Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?

(2009) L. R. Guerin et al.   HUMAN REPRODUCTION UPDATE

Cross-Presentation of Male Seminal Fluid Antigens Elicits T Cell Activation to Initiate the Female Immune Response to Pregnancy

(2009) L. M. Moldenhauer et al.   JOURNAL OF IMMUNOLOGY

Human Chorionic Gonadotropin Attracts Regulatory T Cells into the Fetal-Maternal Interface during Early Human Pregnancy

(2009) A. Schumacher et al.   JOURNAL OF IMMUNOLOGY

Fetal–maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells

(2009) Tamara Tilburgs et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Seminal plasma stimulates cytokine production in endometrial epithelial cell cultures independently of the presence of leucocytes

(2008) R. Ochsenkühn et al.   ANDROLOGIA

The Role of Macrophages in Utero-placental Interactions During Normal and Pathological Pregnancy

(2008) Stephen J. Renaud et al.   IMMUNOLOGICAL INVESTIGATIONS

Uterine DCs are crucial for decidua formation during embryo implantation in mice

(2008) Vicki Plaks et al.   JOURNAL OF CLINICAL INVESTIGATION