Extracellular vesicles in normal pregnancy and pregnancy‐related diseases

Impaired signalling pathways mediated by extracellular vesicles in diabesity

(2019) Tamara Sáez et al.   MOLECULAR ASPECTS OF MEDICINE

Exosomes Cause Preterm Birth in Mice: Evidence for Paracrine Signaling in Pregnancy

(2019) Samantha Sheller-Miller et al.   Scientific Reports

Placental Syncytiotrophoblast-Derived Extracellular Vesicles Carry Active NEP (Neprilysin) and Are Increased in Preeclampsia

(2019) Manjot Gill et al.   HYPERTENSION

MicroRNA Profiles in Extracellular Vesicles From Serum Early in Pregnancies Complicated by Gestational Diabetes Mellitus

(2019) Virginie Gillet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cre-Reporter Mouse Model to Determine Exosome Communication and Function during Pregnancy

(2019) Samantha Sheller-Miller et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Oxidative stress - Related spontaneous preterm delivery challenges in causality determination, prevention and novel strategies in reduction of the sequelae

(2019) Vedran Stefanovic et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Prediction of Gestational Hypertension, Preeclampsia and Fetal Growth Restriction via the First Trimester Screening of Plasma Exosomal C19MC microRNAs

(2019) Ilona Hromadnikova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Unravelling the Role of Trophoblastic-Derived Extracellular Vesicles in Regulatory T Cell Differentiation

(2019) Árpád Ferenc Kovács et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomal microRNA profiling in early and late onset preeclamptic pregnant women reflects pathophysiology

(2019) Preenan Pillay et al.   International Journal of Nanomedicine

Oral extracellular vesicles in early pregnancy can identify patients at risk of developing gestational diabetes mellitus

(2019) Lara J. Monteiro et al.   PLoS One

Fetal lung C4BPA induces p100 processing in human placenta

(2019) Mayra Cruz Ithier et al.   Scientific Reports

Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus

(2019) Neva Kandzija et al.   Journal of Extracellular Vesicles

Placenta-derived extracellular vesicles induce preeclampsia in mouse models

(2019) Cha Han et al.   HAEMATOLOGICA

MicroRNAs: Small molecules with a large impact on pre‐eclampsia

(2019) Maryam Hemmatzadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Placental Exosomes During Gestation: Liquid Biopsies Carrying Signals for the Regulation of Human Parturition

(2018) Carlos Salomon et al.   CURRENT PHARMACEUTICAL DESIGN

Fed-EXosome: extracellular vesicles and cell–cell communication in metabolic regulation

(2018) Isabella Samuelson et al.   Essays in Biochemistry

Maternal and umbilical cord serum–derived exosomes enhance endothelial cell proliferation and migration

(2018) Linyan Jia et al.   FASEB JOURNAL

Early pregnancy immune biomarkers in peripheral blood may predict preeclampsia

(2018) M.D. Salazar Garcia et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Intrauterine inflammatory activation, functional progesterone withdrawal, and the timing of term and preterm birth

(2018) Jeffrey A. Keelan   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Foetoplacental communication via extracellular vesicles in normal pregnancy and preeclampsia

(2018) Delia I. Chiarello et al.   MOLECULAR ASPECTS OF MEDICINE

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth

(2018) Jezid Miranda et al.   PLACENTA

Extracellular vesicles and their immunomodulatory functions in pregnancy

(2018) Soumyalekshmi Nair et al.   Seminars in Immunopathology

Placental exosome-mediated Bta-miR-499-Lin28B/let-7 axis regulates inflammatory bias during early pregnancy

(2018) Gan Zhao et al.   Cell Death & Disease

The impact of circulating preeclampsia-associated extracellular vesicles on the migratory activity and phenotype of THP-1 monocytic cells

(2018) Árpád Ferenc Kovács et al.   Scientific Reports

Amnion Epithelial Cell Derived Exosomes Induce Inflammatory Changes in Uterine Cells

(2018) Emily E. Hadley et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Systematic review of p38 mitogen-activated kinase and its functional role in reproductive tissues

(2018) Samantha Sheller-Miller et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Role of mesenchymal stem cells exosomes derived microRNAs; miR-136, miR-494 and miR-495 in pre-eclampsia diagnosis and evaluation

(2018) Tarek M.k. Motawi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Human Placental Exosomes in Gestational Diabetes Mellitus Carry a Specific Set of miRNAs Associated with Skeletal Muscle Insulin Sensitivity

(2018) Soumyalekshmi Nair et al.   CLINICAL SCIENCE

The Pro-angiogenesis Of Exosomes Derived From Umbilical Cord Blood Of Intrauterine Growth Restriction Pigs Was Repressed Associated With MiRNAs

(2018) Jia Luo et al.   International Journal of Biological Sciences

Pre-eclampsia is associated with altered expression of the renal sodium transporters NKCC2, NCC and ENaC in urinary extracellular vesicles

(2018) Chih-Chiang Hu et al.   PLoS One

Human placental glucose transport in fetoplacental growth and metabolism

(2018) Nicholas P. Illsley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries

(2018) Floor Spaans et al.   CLINICAL SCIENCE

Exosomes From Women With Preeclampsia Induced Vascular Dysfunction by Delivering sFlt (Soluble Fms-Like Tyrosine Kinase)-1 and sEng (Soluble Endoglin) to Endothelial Cells

(2018) Xinwen Chang et al.   HYPERTENSION

Extracellular vesicle mediated embryo-endometrial cross talk during implantation and in pregnancy

(2018) Noble K. Kurian et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

MiRNA-548c-5p downregulates inflammatory response in preeclampsia via targeting PTPRO

(2018) Zengfang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adipose tissue exosomal proteomic profile reveals a role on placenta glucose metabolism in gestational diabetes mellitus

(2018) Nanthini Jayabalan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Quantitative Proteomics by SWATH‐MS Suggest an Association Between Circulating Exosomes and Maternal Metabolic Changes in Gestational Diabetes Mellitus

(2018) Nanthini Jayabalan et al.   PROTEOMICS

Second trimester extracellular microRNAs in maternal blood and fetal growth: An exploratory study

(2017) Rodosthenis S. Rodosthenous et al.   Epigenetics

Placental Nano-vesicles Target to Specific Organs and Modulate Vascular Tone In Vivo

(2017) Mancy Tong et al.   HUMAN REPRODUCTION

Placental Vesicles Carry Active Endothelial Nitric Oxide Synthase and Their Activity is Reduced in PreeclampsiaNovelty and Significance

(2017) Carolina Motta-Mejia et al.   HYPERTENSION

Placental Exosomes as Early Biomarker of Preeclampsia: Potential Role of Exosomal MicroRNAs Across Gestation

(2017) Carlos Salomon et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Urinary Extracellular Vesicles of Podocyte Origin and Renal Injury in Preeclampsia

(2017) Sarwat I. Gilani et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Urine exosomes from healthy and hypertensive pregnancies display elevated level of α-subunit and cleaved α- and γ-subunits of the epithelial sodium channel—ENaC

(2017) Maria R. Nielsen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Influence of maternal BMI on the exosomal profile during gestation and their role on maternal systemic inflammation

(2017) Omar Elfeky et al.   PLACENTA

Syncytiotrophoblast extracellular vesicles impair rat uterine vascular function via the lectin-like oxidized LDL receptor-1

(2017) Floor Spaans et al.   PLoS One

Placental hemostasis and sterile inflammation: New insights into gestational vascular disease

(2017) Shrey Kohli et al.   THROMBOSIS RESEARCH

Uterine Fluid in Pregnancy: A Biological and Clinical Outlook

(2017) Ying Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Syncytiotrophoblast derived extracellular vesicles transfer functional placental miRNAs to primary human endothelial cells

(2017) Tina Cronqvist et al.   Scientific Reports

Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension

(2017) Orsolya Biró et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Programmed Fetal Membrane Senescence and Exosome-Mediated Signaling: A Mechanism Associated With Timing of Human Parturition

(2017) Ramkumar Menon et al.   Frontiers in Endocrinology

Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes

(2017) Nanthini Jayabalan et al.   Frontiers in Endocrinology

Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells – Liquid biopsies for monitoring complications of pregnancy

(2017) Grace Truong et al.   PLoS One

A Single Sphingomyelin Species Promotes Exosomal Release of Endoglin into the Maternal Circulation in Preeclampsia

(2017) Leonardo Ermini et al.   Scientific Reports

Human Endometrial Exosomes Contain Hormone-Specific Cargo Modulating Trophoblast Adhesive Capacity: Insights into Endometrial-Embryo Interactions1

(2016) David W. Greening et al.   BIOLOGY OF REPRODUCTION

Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts

(2016) S. Kohli et al.   BLOOD

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Extracellular vesicles in blood, milk and body fluids of the female and male urogenital tract and with special regard to reproduction

(2016) B. P. Foster et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Proteomic characterization of macro-, micro- and nano-extracellular vesicles derived from the same first trimester placenta: relevance for feto-maternal communication

(2016) Mancy Tong et al.   HUMAN REPRODUCTION

Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition

(2016) Ramkumar Menon et al.   HUMAN REPRODUCTION UPDATE

Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8

(2016) Stefan M. Gysler et al.   MOLECULAR HUMAN REPRODUCTION

Placental exosomes and pre-eclampsia: Maternal circulating levels in normal pregnancies and, early and late onset pre-eclamptic pregnancies

(2016) Preenan Pillay et al.   PLACENTA

Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal-Placental Messaging

(2016) Beth Holder et al.   TRAFFIC

MicroRNA-141 is upregulated in preeclamptic placentae and regulates trophoblast invasion and intercellular communication

(2016) Stephanie Ospina-Prieto et al.   Translational Research

Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation

(2016) Laura M. Desrochers et al.   Nature Communications

Gelsolin is an endogenous inhibitor of syncytiotrophoblast extracellular vesicle shedding in pregnancy

(2016) Neil A. Nadkarni et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Amnion-Epithelial-Cell-Derived Exosomes Demonstrate Physiologic State of Cell under Oxidative Stress

(2016) Samantha Sheller et al.   PLoS One

Placental exosomes in normal and complicated pregnancy

(2015) Murray D. Mitchell et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Why is placentation abnormal in preeclampsia?

(2015) Susan J. Fisher   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

MicroRNA and Embryo Implantation

(2015) Weimin Liu et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The Microenvironment of Human Implantation: Determinant of Reproductive Success

(2015) Lois A. Salamonsen et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

MicroRNAome of Porcine Conceptuses and Trophoblasts: Expression Profile of microRNAs and Their Potential to Regulate Genes Crucial for Establishment of Pregnancy1

(2015) Kamil Krawczynski et al.   BIOLOGY OF REPRODUCTION

Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome

(2015) F. Vilella et al.   DEVELOPMENT

Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation

(2015) Carlos Salomon et al.   DIABETES

The Effect of Glucose on the Release and Bioactivity of Exosomes From First Trimester Trophoblast Cells

(2015) Gregory E. Rice et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Antiphospholipid antibodies bind syncytiotrophoblast mitochondria and alter the proteome of extruded syncytial nuclear aggregates

(2015) Priyadarshini Pantham et al.   PLACENTA

RelB/p52-mediated NF-κB signaling alters histone acetylation to increase the abundance of corticotropin-releasing hormone in human placenta

(2015) Valeria Di Stefano et al.   Science Signaling

Molecular mechanisms of maternal vascular dysfunction in preeclampsia

(2015) Styliani Goulopoulou et al.   TRENDS IN MOLECULAR MEDICINE

RelB/p52-mediated NF-κB signaling alters histone acetylation to increase the abundance of corticotropin-releasing hormone in human placenta

(2015) Valeria Di Stefano et al.   Science Signaling

Placenta-Derived Exosomes and Syncytiotrophoblast Microparticles and their Role in Human Reproduction: Immune Modulation for Pregnancy Success

(2014) Lucia Mincheva-Nilsson et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Extracellular vesicles and reproduction–promotion of successful pregnancy

(2014) Dionne Tannetta et al.   Cellular & Molecular Immunology

Cardiovascular Physiology of Pregnancy

(2014) Monika Sanghavi et al.   CIRCULATION

A Gestational Profile of Placental Exosomes in Maternal Plasma and Their Effects on Endothelial Cell Migration

(2014) Carlos Salomon et al.   PLoS One

Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration

(2014) Carlos Salomon et al.   Frontiers in Pharmacology

Spiral Artery Remodeling and Trophoblast Invasion in Preeclampsia and Fetal Growth Restriction

(2013) Fiona Lyall et al.   HYPERTENSION

Antiphospholipid antibodies internalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris

(2013) Chez A. Viall et al.   JOURNAL OF AUTOIMMUNITY

Exosomes Secreted by Human Placenta Carry Functional Fas Ligand and TRAIL Molecules and Convey Apoptosis in Activated Immune Cells, Suggesting Exosome-Mediated Immune Privilege of the Fetus

(2013) A.-C. Stenqvist et al.   JOURNAL OF IMMUNOLOGY

Human placental trophoblasts confer viral resistance to recipient cells

(2013) E. Delorme-Axford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of serum and urinary nephrin levels between normal pregnancies and severe preeclampsia

(2012) Ga Hyun Son et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Trophoblast deportation part II: A review of the maternal consequences of trophoblast deportation

(2011) P. Pantham et al.   PLACENTA

Trophoblast deportation part I: Review of the evidence demonstrating trophoblast shedding and deportation during human pregnancy

(2011) K.J. Askelund et al.   PLACENTA