HIV-Induced CPSF6 Condensates

Spatial and Genomic Correlates of HIV-1 Integration Site Targeting

(2022) Parmit Kumar Singh et al.   Cells

Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection

(2022) Guochao Wei et al.   Nature Communications

Scaffolding viral protein NC nucleates phase separation of the HIV-1 biomolecular condensate

(2022) Anne Monette et al.   Cell Reports

Evasion of cGAS and TRIM5 defines pandemic HIV

(2022) Lorena Zuliani-Alvarez et al.   Nature Microbiology

The roles of CPSF6 in proliferation, apoptosis and tumorigenicity of lung adenocarcinoma

(2022) Yukun Zu et al.   Aging-US

Cone-shaped HIV-1 capsids are transported through intact nuclear pores

(2021) Vojtech Zila et al.   CELL

CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression

(2021) Sheng Tan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

C. elegans germ granules require both assembly and localized regulators for mRNA repression

(2021) Scott Takeo Aoki et al.   Nature Communications

Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner

(2021) Zhou Zhong et al.   mBio

Membraneless organelles restructured and built by pandemic viruses: HIV-1 and SARS-CoV-2

(2021) Viviana Scoca et al.   Journal of Molecular Cell Biology

HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

(2021) Thorsten G Müller et al.   eLife

A condensate-hardening drug blocks RSV replication in vivo

(2021) Jennifer Risso-Ballester et al.   NATURE

Designer membraneless organelles sequester native factors for control of cell behavior

(2021) Mikael V. Garabedian et al.   Nature Chemical Biology

rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo

(2021) Gregory J Bedwell et al.   NUCLEIC ACIDS RESEARCH

The Viral Capsid: A Master Key to Access the Host Nucleus

(2021) Guillermo Blanco-Rodriguez et al.   Viruses-Basel

HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration

(2021) Anabel Guedán et al.   PLoS Pathogens

Phase separation of a plant virus movement protein and cellular factors support virus-host interactions

(2021) Shelby L. Brown et al.   PLoS Pathogens

Phase separation of Epstein-Barr Virus EBNA2 and Its Coactivator EBNALP controls gene expression

(2020) Qiu Peng et al.   JOURNAL OF VIROLOGY

Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation

(2020) Jamie A. Greig et al.   MOLECULAR CELL

The HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b

(2020) Evan Chaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Remodeling of the Core Leads HIV-1 Preintegration Complex into the Nucleus of Human Lymphocytes

(2020) Guillermo Blanco-Rodriguez et al.   JOURNAL OF VIROLOGY

Pan-retroviral Nucleocapsid-Mediated Phase Separation Regulates Genomic RNA Positioning and Trafficking

(2020) Anne Monette et al.   Cell Reports

Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus

(2020) Adarsh Dharan et al.   Nature Microbiology

Double-Membrane Vesicles as Platforms for Viral Replication

(2020) Georg Wolff et al.   TRENDS IN MICROBIOLOGY

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration

(2020) Wen Li et al.   mBio

Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating

(2020) Anastasia Selyutina et al.   Cell Reports

SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs

(2020) Theodora Myrto Perdikari et al.   EMBO JOURNAL

Clustering and reverse transcription of HIV‐1 genomes in nuclear niches of macrophages

(2020) Elena Rensen et al.   EMBO JOURNAL

Liquid–Liquid Phase Separation by Intrinsically Disordered Protein Regions of Viruses: Roles in Viral Life Cycle and Control of Virus–Host Interactions

(2020) Stefania Brocca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

(2020) Christiane Iserman et al.   MOLECULAR CELL

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the Nuclear Pore Complex

(2019) David Alejandro Bejarano et al.   eLife

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

(2019) Sooin Jang et al.   NUCLEIC ACIDS RESEARCH

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation

(2019) Simona Krasnopolsky et al.   Retrovirology

Acute myeloid leukemia with a novel CPSF6‐RARG variant is sensitive to homoharringtonine and cytarabine chemotherapy

(2019) Zhanglin Zhang et al.   AMERICAN JOURNAL OF HEMATOLOGY

Virus–Host Coevolution with a Focus on Animal and Human DNA Viruses

(2019) Győző L. Kaján et al.   JOURNAL OF MOLECULAR EVOLUTION

Reentrant Phase Transitions and Non-Equilibrium Dynamics in Membraneless Organelles

(2018) Anthony N. Milin et al.   BIOCHEMISTRY

Do Cellular Condensates Accelerate Biochemical Reactions? Lessons from Microdroplet Chemistry

(2018) Wylie Stroberg et al.   BIOPHYSICAL JOURNAL

Identification of novel recurrent CPSF6-RARG fusions in acute myeloid leukemia resembling acute promyelocytic leukemia

(2018) Tianhui Liu et al.   BLOOD

Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus

(2018) Sofia A. Quinodoz et al.   CELL

Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Non-dividing Cells

(2018) Cindy Buffone et al.   JOURNAL OF VIROLOGY

Identification of a novel CPSF6-RARG fusion transcript in acute myeloid leukemia resembling acute promyelocytic leukemia

(2018) Ya-Zhen Qin et al.   LEUKEMIA

Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module

(2018) Todd R Albrecht et al.   NUCLEIC ACIDS RESEARCH

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

(2018) Vasudevan Achuthan et al.   Cell Host & Microbe

Controllable protein phase separation and modular recruitment to form responsive membraneless organelles

(2018) Benjamin S. Schuster et al.   Nature Communications

Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome

(2018) Yongdae Shin et al.   CELL

Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds

(2018) Dan Bracha et al.   CELL

Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies

(2018) Chi LL Pham et al.   EMBO REPORTS

Membraneless nuclear organelles and the search for phases within phases

(2018) Iain A. Sawyer et al.   Wiley Interdisciplinary Reviews-RNA

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ebola virus VP35 blocks stress granule assembly

(2017) Valerie Le Sage et al.   VIROLOGY

Negri bodies are viral factories with properties of liquid organelles

(2017) Jovan Nikolic et al.   Nature Communications

CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target

(2017) Najat Binothman et al.   EBioMedicine

Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation

(2016) J. G. Hardy et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mechanisms and Consequences of Macromolecular Phase Separation

(2016) Louis-Philippe Bergeron-Sandoval et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

Nucleation by rRNA Dictates the Precision of Nucleolus Assembly

(2016) Hanieh Falahati et al.   CURRENT BIOLOGY

Droplet organelles?

(2016) Edward M Courchaine et al.   EMBO JOURNAL

Nuclear bodies: Built to boost

(2016) Iain A. Sawyer et al.   JOURNAL OF CELL BIOLOGY

Simple rules for passive diffusion through the nuclear pore complex

(2016) Benjamin L. Timney et al.   JOURNAL OF CELL BIOLOGY

Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions

(2016) Valentina Quercioli et al.   JOURNAL OF VIROLOGY

Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus PassageIn Vivo

(2016) Akatsuki Saito et al.   JOURNAL OF VIROLOGY

Alternative polyadenylation of mRNA precursors

(2016) Bin Tian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

(2016) Gregory A. Sowd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAPERCLIP Identifies MicroRNA Targets and a Role of CstF64/64tau in Promoting Non-canonical poly(A) Site Usage

(2016) Hun-Way Hwang et al.   Cell Reports

Virus assembly factories in a lipid world

(2016) Isabel Fernández de Castro et al.   Current Opinion in Virology

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Fusion ofPDGFRBtoMPRIP, CPSF6, andGOLGB1in three patients with eosinophilia-associated myeloproliferative neoplasms

(2015) Nicole Naumann et al.   GENES CHROMOSOMES & CANCER

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Nuclear architecture dictates HIV-1 integration site selection

(2015) Bruna Marini et al.   NATURE

Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles

(2015) William M. Aumiller et al.   Nature Chemistry

Polymer physics of intracellular phase transitions

(2015) Clifford P. Brangwynne et al.   Nature Physics

Three-dimensional genome architecture: players and mechanisms

(2015) Ana Pombo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA transcription modulates phase transition-driven nuclear body assembly

(2015) Joel Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin organization at the nuclear pore favours HIV replication

(2015) Mickaël Lelek et al.   Nature Communications

Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration

(2015) Christopher R. Chin et al.   Cell Reports

Impairment of HIV-1 cDNA Synthesis by DBR1 Knockdown

(2014) A. E. Galvis et al.   JOURNAL OF VIROLOGY

The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites

(2014) Jason A. West et al.   MOLECULAR CELL

Structural basis for nuclear import of splicing factors by human Transportin 3

(2014) G. N. Maertens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran

(2014) Vicky G. Tsirkone et al.   Acta Crystallographica Section F-Structural Biology Communications

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6

(2013) Thomas Fricke et al.   Retrovirology

Virus factories: biogenesis and structural design

(2012) Isabel Fernández de Castro et al.   CELLULAR MICROBIOLOGY

TNPO3 Is Required for HIV-1 Replication after Nuclear Import but prior to Integration and Binds the HIV-1 Core

(2012) J. C. Valle-Casuso et al.   JOURNAL OF VIROLOGY

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Beyond Oil and Water--Phase Transitions in Cells

(2012) A. A. Hyman et al.   SCIENCE

Genome-wide Analysis of Pre-mRNA 3′ End Processing Reveals a Decisive Role of Human Cleavage Factor I in the Regulation of 3′ UTR Length

(2012) Georges Martin et al.   Cell Reports

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soft active aggregates: mechanics, dynamics and self-assembly of liquid-like intracellular protein bodies

(2011) Clifford P. Brangwynne   Soft Matter

Crystal Structure of a Human Cleavage Factor CFIm25/CFIm68/RNA Complex Provides an Insight into Poly(A) Site Recognition and RNA Looping

(2011) Qin Yang et al.   STRUCTURE

Virus factories, double membrane vesicles and viroplasm generated in animal cells

(2011) Christopher L Netherton et al.   Current Opinion in Virology

Flexible Use of Nuclear Import Pathways by HIV-1

(2010) KyeongEun Lee et al.   Cell Host & Microbe

Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion

(2010) Sandra Krull et al.   EMBO JOURNAL

Biogenesis of Nuclear Bodies

(2010) M. Dundr et al.   Cold Spring Harbor Perspectives in Biology

The t(1;9)(p34;q34) and t(8;12)(p11;q15) fuse pre-mRNA processing proteinsSFPQ (PSF) andCPSF6 toABL andFGFR1

(2008) Claire Hidalgo-Curtis et al.   GENES CHROMOSOMES & CANCER

Characterization of the Early Steps of Infection of Primary Blood Monocytes by Human Immunodeficiency Virus Type 1

(2008) V. Arfi et al.   JOURNAL OF VIROLOGY