HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration

The Role of Capsid in HIV-1 Nuclear Entry

(2021) Anabel Guedán et al.   Viruses-Basel

Capsid labelled HIV to investigate the role of capsid during nuclear import and integration

(2020) Irena Zurnic Bönisch et al.   JOURNAL OF VIROLOGY

HIV-1 uncoats in the nucleus near sites of integration

(2020) Ryan C. Burdick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remodeling of the Core Leads HIV-1 Preintegration Complex into the Nucleus of Human Lymphocytes

(2020) Guillermo Blanco-Rodriguez et al.   JOURNAL OF VIROLOGY

Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus

(2020) Adarsh Dharan et al.   Nature Microbiology

Clinical targeting of HIV capsid protein with a long-acting small molecule

(2020) John O. Link et al.   NATURE

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

(2020) Ashwanth C. Francis et al.   Nature Communications

Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro

(2020) Devin E. Christensen et al.   SCIENCE

Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating

(2020) Anastasia Selyutina et al.   Cell Reports

Clustering and reverse transcription of HIV‐1 genomes in nuclear niches of macrophages

(2020) Elena Rensen et al.   EMBO JOURNAL

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the Nuclear Pore Complex

(2019) David Alejandro Bejarano et al.   eLife

Analysis of CA Content and CPSF6 Dependence of Early HIV-1 Replication Complexes in SupT1-R5 Cells

(2019) Vojtech Zila et al.   mBio

Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating

(2019) Juliette Fernandez et al.   Nature Microbiology

Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport

(2018) Ashwanth C. Francis et al.   Cell Host & Microbe

Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis

(2018) Madushi Wanaguru et al.   PLoS Pathogens

Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis

(2018) Chantal L Márquez et al.   eLife

PF74 Reinforces the HIV-1 Capsid To Impair Reverse Transcription-Induced Uncoating

(2018) Sanela Rankovic et al.   JOURNAL OF VIROLOGY

Early cytoplasmic uncoating is associated with infectivity of HIV-1

(2017) João I. Mamede et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes

(2017) Ryan C. Burdick et al.   PLoS Pathogens

The Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Subunit of the Capsid-recruited Pre-messenger RNA Cleavage Factor I (CFIm) Complex Mediates HIV-1 Integration into Genes

(2016) Sheeba Rasheedi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the mechanical properties of wild type and hyperstable mutants of the HIV-1 capsid

(2016) Ruben Ramalho et al.   Retrovirology

HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription

(2016) Ophélie Cosnefroy et al.   Retrovirology

The structure and flexibility of conical HIV-1 capsids determined within intact virions

(2016) Simone Mattei et al.   SCIENCE

Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells

(2016) Ashwanth C. Francis et al.   PLoS Pathogens

KIF5B and Nup358 Cooperatively Mediate the Nuclear Import of HIV-1 during Infection

(2016) Adarsh Dharan et al.   PLoS Pathogens

HIV-1 capsid: the multifaceted key player in HIV-1 infection

(2015) Edward M. Campbell et al.   NATURE REVIEWS MICROBIOLOGY

X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability

(2015) A. T. Gres et al.   SCIENCE

HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus

(2015) Viacheslav Malikov et al.   Nature Communications

Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration

(2015) Christopher R. Chin et al.   Cell Reports

HIV-1 Uncoating Is Facilitated by Dynein and Kinesin 1

(2014) Z. Lukic et al.   JOURNAL OF VIROLOGY

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

(2014) Akash Bhattacharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of HIV-1 capsid in viral replication and immune evasion

(2014) Valerie Le Sage et al.   VIRUS RESEARCH

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

(2014) Amanda J. Price et al.   PLoS Pathogens

HIV-1 Induces the Formation of Stable Microtubules to Enhance Early Infection

(2013) Yosef Sabo et al.   Cell Host & Microbe

Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution

(2013) Lalit Deshmukh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics

(2013) Gongpu Zhao et al.   NATURE

The NTD-CTD intersubunit interface plays a critical role in assembly and stabilization of the HIV-1 capsid

(2013) Ernest L Yufenyuy et al.   Retrovirology

HIV Restriction Factors and Mechanisms of Evasion

(2013) M. H. Malim et al.   Cold Spring Harbor Perspectives in Medicine

Inhibition of Reverse Transcriptase Activity Increases Stability of the HIV-1 Core

(2012) Y. Yang et al.   JOURNAL OF VIROLOGY

Human Nucleoporins Promote HIV-1 Docking at the Nuclear Pore, Nuclear Import and Integration

(2012) Francesca Di Nunzio et al.   PLoS One

Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects

(2012) Ruifeng Yang et al.   Retrovirology

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

(2012) Amanda J. Price et al.   PLoS Pathogens

Design of in Vitro Symmetric Complexes and Analysis by Hybrid Methods Reveal Mechanisms of HIV Capsid Assembly

(2011) Mark Yeager   JOURNAL OF MOLECULAR BIOLOGY

The Requirement for Nucleoporin NUP153 during Human Immunodeficiency Virus Type 1 Infection Is Determined by the Viral Capsid

(2011) K. A. Matreyek et al.   JOURNAL OF VIROLOGY

Atomic-level modelling of the HIV capsid

(2011) Owen Pornillos et al.   NATURE

Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription

(2011) A. E. Hulme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

(2011) Torsten Schaller et al.   PLoS Pathogens

Rhesus TRIM5α Disrupts the HIV-1 Capsid at the Inter­Hexamer Interfaces

(2011) Gongpu Zhao et al.   PLoS Pathogens

Disulfide Bond Stabilization of the Hexameric Capsomer of Human Immunodeficiency Virus

(2010) Owen Pornillos et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the HIV-1 Full-Length Capsid Protein in a Conformationally Trapped Unassembled State Induced by Small-Molecule Binding

(2010) Shoucheng Du et al.   JOURNAL OF MOLECULAR BIOLOGY

Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Infection by Virus Capsid Destabilization

(2010) J. Shi et al.   JOURNAL OF VIROLOGY

Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function

(2009) In-Ja L. Byeon et al.   CELL

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

(2009) Owen Pornillos et al.   CELL

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

(2008) Renate König et al.   CELL

Transportin-SR2 Imports HIV into the Nucleus

(2008) Frauke Christ et al.   CURRENT BIOLOGY

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE

APOBEC3G Inhibits Elongation of HIV-1 Reverse Transcripts

(2008) Kate N. Bishop et al.   PLoS Pathogens