Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks

DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders

(2022) Vincent E. Provasek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA polymerase η promotes nonhomologous end joining upon etoposide exposure dependent on the scaffolding protein Kap1

(2022) Xiaolu Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization

(2021) Jian Wang et al.   Cell Reports

AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ

(2021) Yuejing Jiang et al.   Cell Reports

Polθ promotes the repair of 5′-DNA-protein crosslinks by microhomology-mediated end-joining

(2021) Gurushankar Chandramouly et al.   Cell Reports

DNA Polymerase θ: A Cancer Drug Target with Reverse Transcriptase Activity

(2021) Xiaojiang S. Chen et al.   Genes

Polθ reverse transcribes RNA and promotes RNA-templated DNA repair

(2021) Gurushankar Chandramouly et al.   Science Advances

Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ

(2021) Amelie Schellenbauer et al.   NUCLEIC ACIDS RESEARCH

Deciphering UV‐induced DNA Damage Responses to Prevent and Treat Skin Cancer

(2020) Jihoon W. Lee et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Deficiency in classical nonhomologous end-joining–mediated repair of transcribed genes is linked to SCA3 pathogenesis

(2020) Anirban Chakraborty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Characterization of Three Distinct Mechanisms Supporting RNA-Driven DNA Repair and Modification Reveals Major Role of DNA Polymerase ζ

(2020) Chance Meers et al.   MOLECULAR CELL

Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination

(2020) Kai-Lieh Huang et al.   MOLECULAR CELL

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

(2019) Joy Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human DNA polymerase η has reverse transcriptase activity in cellular environments

(2019) Yan Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

(2019) Rui Gao et al.   eLife

Emerging Perspectives on DNA double-strand breaks in Neurodegenerative Diseases

(2019) Ling-Shuang Zhu et al.   Current Neuropharmacology

Molecular basis of microhomology-mediated end-joining by purified full-length Polθ

(2019) Samuel J. Black et al.   Nature Communications

Harnessing DNA Double-Strand Break Repair for Cancer Treatment

(2019) Anika Trenner et al.   Frontiers in Oncology

Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining

(2018) John M. Pryor et al.   SCIENCE

Multifaceted activities of DNA polymerase η: beyond translesion DNA synthesis

(2018) Narottam Acharya et al.   CURRENT GENETICS

Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease

(2017) Velmarini Vasquez et al.   JOURNAL OF ALZHEIMERS DISEASE

Human DNA polymerase η accommodates RNA for strand extension

(2017) Yan Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rad52 Inverse Strand Exchange Drives RNA-Templated DNA Double-Strand Break Repair

(2017) Olga M. Mazina et al.   MOLECULAR CELL

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA polymerase beta participates in DNA End-joining

(2017) Sreerupa Ray et al.   NUCLEIC ACIDS RESEARCH

Translesion synthesis DNA polymerase η exhibits a specific RNA extension activity and a transcription-associated function

(2017) Vamsi K. Gali et al.   Scientific Reports

DNA repair by RNA: Templated, or not templated, that is the question

(2016) Chance Meers et al.   DNA REPAIR

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

(2016) David W. Wyatt et al.   MOLECULAR CELL

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CRISPR-Cas9 mediated genetic engineering for the purification of the endogenous integrator complex from mammalian cells

(2016) David Baillat et al.   PROTEIN EXPRESSION AND PURIFICATION

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

(2016) Anirban Chakraborty et al.   Nature Communications

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

(2016) Laura Garcia-Exposito et al.   Cell Reports

Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation

(2015) Anirban Chakraborty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination

(2015) Leizhen Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A generic strategy for CRISPR-Cas9-mediated gene tagging

(2015) Daniel H. Lackner et al.   Nature Communications

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

(2015) Arpita Chatterjee et al.   PLoS Genetics

Nonhomologous end joining: A good solution for bad ends

(2014) Crystal A. Waters et al.   DNA REPAIR

ATM: Expanding roles as a chief guardian of genome stability

(2014) Yosef Shiloh   EXPERIMENTAL CELL RESEARCH

Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Bypass by Human DNA Polymerase η

(2014) Amritraj Patra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcript-RNA-templated DNA recombination and repair

(2014) Havva Keskin et al.   NATURE

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Repair of DNA double-strand breaks by templated nucleotide sequence insertions derived from distant regions of the genome

(2014) M. Onozawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA DSB repair pathway choice: an orchestrated handover mechanism

(2013) A Kakarougkas et al.   BRITISH JOURNAL OF RADIOLOGY

A direct role for small non-coding RNAs in DNA damage response

(2013) Fabrizio d’Adda di Fagagna   TRENDS IN CELL BIOLOGY

In Vivo Bypass of 8-oxodG

(2013) Gina P. Rodriguez et al.   PLoS Genetics

DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT

(2013) Leonid Schneider et al.   Stem Cell Reports

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

Translesion DNA Polymerases and Cancer

(2012) Nick M. Makridakis et al.   Frontiers in Genetics

Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3′-Phosphatase in Maintenance of Mitochondrial Genome

(2011) Santi M. Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA-driven genetic changes in bacteria and in human cells

(2011) Ying Shen et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Structural Basis for Error-free Replication of Oxidatively Damaged DNA by Yeast DNA Polymerase η

(2010) Timothy D. Silverstein et al.   STRUCTURE

Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells

(2009) Rémy Bétous et al.   MOLECULAR CARCINOGENESIS

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases   and  

(2009) S. D. McCulloch et al.   NUCLEIC ACIDS RESEARCH

Highly error-free role of DNA polymerase   in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells

(2009) J.-H. Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry