Differential Effects of Hypoxia versus Hyperoxia or Physoxia on Phenotype and Energy Metabolism in Human Chondrocytes from Osteoarthritic Compared to Macroscopically Normal Cartilage

Dysregulated energy metabolism impairs chondrocyte function in osteoarthritis

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SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α

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Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling

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The Effects of Age and Cell Isolation on Collagen II Synthesis by Articular Chondrocytes: Evidence for Transcriptional and Posttranscriptional Regulation

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Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy

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Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology

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The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis

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Cartilage Metabolism, Mitochondria, and Osteoarthritis

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Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy

(2018) Purva Singh et al.   Annals of the New York Academy of Sciences

Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis

(2018) Xiaobo Yang et al.   DNA AND CELL BIOLOGY

Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential

(2018) Claire Mennan et al.   Cartilage

Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Phenotype Markers in Primary Human Chondrocytes by a Calcium/Calmodulin Kinase 2-Dependent Mechanism

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Knee osteoarthritis: pathophysiology and current treatment modalities

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Is osteoarthritis one disease or a collection of many?

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Combining Targeted Metabolomic Data with a Model of Glucose Metabolism: Toward Progress in Chondrocyte Mechanotransduction

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Metabolic consequences of oncogenic IDH mutations

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Hypoxia Promotes the Production and Inhibits the Destruction of Human Articular Cartilage

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Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia

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A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis

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Hypoxia promotes redifferentiation and suppresses markers of hypertrophy and degeneration in both healthy and osteoarthritic chondrocytes

(2013) Brandon D Markway et al.   ARTHRITIS RESEARCH & THERAPY

Metabolic syndrome meets osteoarthritis

(2012) Qi Zhuo et al.   Nature Reviews Rheumatology

Comparison of cartilage histopathology assessment systems on human knee joints at all stages of osteoarthritis development

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Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis

(2012) Mary B. Goldring   Therapeutic Advances in Musculoskeletal Disease

Analysis of Post Transcriptional Regulation of SOX9 mRNA During In Vitro Chondrogenesis

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Hypoxia-inducible factor 1α inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: Hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1α-dependent redifferentiation of chondrocytes

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A Novel in Vitro Model to Investigate Behavior of Articular Chondrocytes in Osteoarthritis

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The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

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