Hypoxia promotes redifferentiation and suppresses markers of hypertrophy and degeneration in both healthy and osteoarthritic chondrocytes

Hypoxia Promotes the Production and Inhibits the Destruction of Human Articular Cartilage

(2013) Brendan L. Thoms et al.   ARTHRITIS AND RHEUMATISM

Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia

(2013) Victoria Clérigues et al.   CLINICAL SCIENCE

Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites

(2013) Ko Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A large-scale replication study for the association of rs17039192 in HIF-2α with knee osteoarthritis

(2012) Masahiro Nakajima et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development

(2011) Elisa Araldi et al.   NATURE MEDICINE

Effects of Oxygen on Zonal Marker Expression in Human Articular Chondrocytes

(2011) Karsten Schrobback et al.   TISSUE ENGINEERING PART A

HIF-2α - a mediator of osteoarthritis?

(2010) Christopher L Murphy   CELL RESEARCH

Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38

(2010) Sohel M. Julovi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Hypoxia Conditions Differentially Modulate Human Normal and Osteoarthritic Chondrocyte Proteomes

(2010) Cristina Ruiz-Romero et al.   JOURNAL OF PROTEOME RESEARCH

Shifting HIFs in osteoarthritis

(2010) Matthew Husa et al.   NATURE MEDICINE

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages

(2010) Simon Ströbel et al.   ARTHRITIS RESEARCH & THERAPY

Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy

(2009) Jolene Bohensky et al.   ARTHRITIS AND RHEUMATISM

Hypoxia-inducible factor 1α inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: Hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1α-dependent redifferentiation of chondrocytes

(2009) Elise Duval et al.   ARTHRITIS AND RHEUMATISM

Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation

(2009) Tilo Dehne et al.   ARTHRITIS RESEARCH & THERAPY

Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes

(2008) T Yatabe et al.   ANNALS OF THE RHEUMATIC DISEASES