Klotho alleviates contrast-induced acute kidney injury by suppressing oxidative stress, inflammation, and NF-KappaB/NLRP3-mediated pyroptosis

αKlotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy

(2021) Xuying Zhu et al.   PHARMACOLOGICAL RESEARCH

APELA/ELA32 Reduces Iodixanol-induced Apoptosis, Inflammatory Response and Mitochondrial and DNA Damage in Renal Tubular Epithelial Cells

(2020) YIMIN LI et al.   ANTICANCER RESEARCH

Acetylbritannilactone attenuates contrast-induced acute kidney injury through its anti-pyroptosis effects

(2020) Fei Chen et al.   BIOSCIENCE REPORTS

Klotho protein contributes to cardioprotection during ischaemia/reperfusion injury

(2020) Agnieszka Olejnik et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Mechanism of Contrast-Induced Acute Kidney Injury and Its Association with Diabetes Mellitus

(2020) Yanfei Li et al.   Contrast Media & Molecular Imaging

Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches

(2020) Prit Kusirisin et al.   Journal of Translational Medicine

Ameliorating Effect of Klotho Protein on Rat Heart during I/R Injury

(2020) Agnieszka Olejnik et al.   Oxidative Medicine and Cellular Longevity

Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling

(2019) Sanaa M. Abd El-Twab et al.   INFLAMMATION RESEARCH

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kidney Biomarkers of Injury and Repair as Predictors of Contrast-Associated AKI: A Substudy of the PRESERVE Trial

(2019) Chirag R. Parikh et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

Klotho, the elusive kidney-derived anti-ageing factor

(2019) Maria Dolores Sanchez-Niño et al.   Clinical Kidney Journal

Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo

(2018) Yue Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

(2018) Xianxian Wu et al.   Cell Death & Disease

Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury

(2018) Zhen Zhang et al.   Cell Death & Disease

The Klotho proteins in health and disease

(2018) Makoto Kuro-o   Nature Reviews Nephrology

Quercetin protects against radiocontrast medium toxicity in human renal proximal tubular cells

(2017) Michele Andreucci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

(2017) Andrea Stutz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recombinant α-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy

(2017) Ming Chang Hu et al.   KIDNEY INTERNATIONAL

Understanding and preventing contrast-induced acute kidney injury

(2017) Michael Fähling et al.   Nature Reviews Nephrology

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Sulodexide Protects Renal Tubular Epithelial Cells from Oxidative Stress-Induced Injury via Upregulating Klotho Expression at an Early Stage of Diabetic Kidney Disease

(2017) Yu Ning Liu et al.   Journal of Diabetes Research

New Insights into the Mechanism of Action of Soluble Klotho

(2017) George D. Dalton et al.   Frontiers in Endocrinology

Contrast-Induced Acute Kidney Injury: An Update

(2016) George Chalikias et al.   CARDIOVASCULAR DRUGS AND THERAPY

Pyroptosis

(2016) Lieselotte Vande Walle et al.   CURRENT BIOLOGY

NLRP3 inflammasome expression is driven by NF-κB in cultured hepatocytes

(2015) Sorina Georgiana Boaru et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death

(2014) Xuezhong Gong et al.   ARCHIVES OF TOXICOLOGY

Relationship Between Inflammation and Benefits of Early High-Dose Rosuvastatin on Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome

(2014) Anna Toso et al.   JACC-Cardiovascular Interventions

Risk of Intravenous Contrast Material–mediated Acute Kidney Injury: A Propensity Score–matched Study Stratified by Baseline-estimated Glomerular Filtration Rate

(2014) Jennifer S. McDonald et al.   RADIOLOGY

Nano-Sized CT Contrast Agents

(2013) Nohyun Lee et al.   ADVANCED MATERIALS

Pharmacokinetics of Contrast Media in Humans

(2011) Rüdiger Lawaczeck et al.   INVESTIGATIVE RADIOLOGY

In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis

(2011) C Quintavalle et al.   Cell Death & Disease