Good CARMA: Turning bad tumor‐resident myeloid cells good with chimeric antigen receptor macrophages

Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis

(2023) Chuanlin Ding et al.   NATURE IMMUNOLOGY

Functional states of myeloid cells in cancer

(2023) Lilian van Vlerken-Ysla et al.   CANCER CELL

Magrolimab in Combination With Azacitidine in Patients With Higher-Risk Myelodysplastic Syndromes: Final Results of a Phase Ib Study

(2023) David A. Sallman et al.   JOURNAL OF CLINICAL ONCOLOGY

Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy

(2023) Chong Zuo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

M1 polarization enhances the antitumor activity of chimeric antigen receptor macrophages in solid tumors

(2023) Yi Huo et al.   Journal of Translational Medicine

CAR immune cells: design principles, resistance and the next generation

(2023) Louai Labanieh et al.   NATURE

CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions

(2023) Pu-Ste Liu et al.   NATURE IMMUNOLOGY

Convection-enhanced delivery of nanoencapsulated gene locoregionally yielding ErbB2/Her2-specific CAR-macrophages for brainstem glioma immunotherapy

(2023) Lin Gao et al.   JOURNAL OF NANOBIOTECHNOLOGY

Breast Cancers Are Immunogenic: Immunologic Analyses and a Phase II Pilot Clinical Trial Using Mutation-Reactive Autologous Lymphocytes

(2022) Nikolaos Zacharakis et al.   JOURNAL OF CLINICAL ONCOLOGY

Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells

(2022) Lucia Borriello et al.   Nature Communications

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Pan-Cancer Analysis Shows Enrichment of Macrophages, Overexpression of Checkpoint Molecules, Inhibitory Cytokines, and Immune Exhaustion Signatures in EMT-High Tumors

(2022) Jayesh Kumar Tiwari et al.   Frontiers in Oncology

Anti-CSF-1R emactuzumab in combination with anti-PD-L1 atezolizumab in advanced solid tumor patients naïve or experienced for immune checkpoint blockade

(2022) Carlos Gomez-Roca et al.   Journal for ImmunoTherapy of Cancer

Ex Vivo Generation of CAR Macrophages from Hematopoietic Stem and Progenitor Cells for Use in Cancer Therapy

(2022) Daniela Paasch et al.   Cells

CD206+ tumor-associated macrophages cross-present tumor antigen and drive anti-tumor immunity

(2022) Madhura Modak et al.   JCI Insight

The complex role of tumor-infiltrating macrophages

(2022) Anthos Christofides et al.   NATURE IMMUNOLOGY

Hypoxia-inducible lentiviral gene expression in engineered human macrophages

(2022) Harrison K Chinn et al.   Journal for ImmunoTherapy of Cancer

Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer

(2022) Briana G. Nixon et al.   IMMUNITY

Multispectral fluorine-19 MRI enables longitudinal and noninvasive monitoring of tumor-associated macrophages

(2022) Davide Croci et al.   Science Translational Medicine

IL12 immune therapy clinical trial review: Novel strategies for avoiding CRS-associated cytokines

(2022) Zhiliang Jia et al.   Frontiers in Immunology

Targeting TNF-α producing macrophages activate antitumor immunity in pancreatic cancer through IL33 signaling

(2022) Ajay Dixit et al.   JCI Insight

Surgical wounding enhances pro‐tumor macrophage responses and accelerates tumor growth and lung metastasis in a triple negative breast cancer mouse model

(2022) Sierra J. McDonald et al.   Physiological Reports

CAR-Macrophages and CAR-T Cells Synergistically Kill Tumor Cells In Vitro

(2022) Maoxuan Liu et al.   Cells

The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors—A Review of Literature

(2021) Jan Korbecki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination

(2021) Jiali Yu et al.   NATURE MEDICINE

Tumor Heterogeneity: A Great Barrier in the Age of Cancer Immunotherapy

(2021) Nader El-Sayes et al.   Cancers

Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis

(2021) Sabina Kaczanowska et al.   CELL

Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer

(2021) Jingwei Shi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

(2021) Ana Rita Pombo Antunes et al.   NATURE NEUROSCIENCE

Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins

(2021) Joseph Hiatt et al.   Cell Reports

Tumor-Associated Macrophage Promotes the Survival of Cancer Cells upon Docetaxel Chemotherapy via the CSF1/CSF1R–CXCL12/CXCR4 Axis in Castration-Resistant Prostate Cancer

(2021) Wei Guan et al.   Genes

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

(2021) María Casanova-Acebes et al.   NATURE

Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer

(2021) Yanjuan Huang et al.   Nature Communications

Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis

(2021) Guya D. Marconi et al.   Cells

HIF1α epigenetically repressed macrophages via CRISPR/Cas9-EZH2 system for enhanced cancer immunotherapy

(2021) Yan Dong et al.   Bioactive Materials

Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation

(2021) Jaikumar Duraiswamy et al.   CANCER CELL

Hallmarks of response, resistance, and toxicity to immune checkpoint blockade

(2021) Golnaz Morad et al.   CELL

BiTE secretion from in situ-programmed myeloid cells results in tumor-retained pharmacology

(2021) S. Hao et al.   JOURNAL OF CONTROLLED RELEASE

Tumor‐infiltrating M2 macrophage in pretreatment biopsy sample predicts response to chemotherapy and survival in esophageal cancer

(2020) Kei Yamamoto et al.   CANCER SCIENCE

Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction

(2020) Kohei Kobatake et al.   CLINICAL CANCER RESEARCH

Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

(2020) Yi Zhou et al.   IMMUNITY

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

(2020) Enli Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

(2020) Jesse M. Jaynes et al.   Science Translational Medicine

mRNA Transfection-Induced Activation of Primary Human Monocytes and Macrophages: Dependence on Carrier System and Nucleotide Modification

(2020) Hanieh Moradian et al.   Scientific Reports

Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9

(2020) Emily C. Freund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human chimeric antigen receptor macrophages for cancer immunotherapy

(2020) Michael Klichinsky et al.   NATURE BIOTECHNOLOGY

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

(2020) Ioannis Kourtzelis et al.   Frontiers in Immunology

Cellular backpacks for macrophage immunotherapy

(2020) C. Wyatt Shields et al.   Science Advances

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

(2020) Martina Molgora et al.   CELL

Determinants of Resident Tissue Macrophage Identity and Function

(2020) Camille Blériot et al.   IMMUNITY

Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance

(2020) Leila Akkari et al.   Science Translational Medicine

Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors

(2020) Qingyang Lei et al.   Frontiers in Cell and Developmental Biology

Phase Ib study of anti-CSF-1R antibody emactuzumab in combination with CD40 agonist selicrelumab in advanced solid tumor patients

(2020) Jean-Pascal Machiels et al.   Journal for ImmunoTherapy of Cancer

Chimeric antigen receptor‐modified macrophages trigger systemic anti‐tumour immunity

(2020) Zhiyuan Niu et al.   JOURNAL OF PATHOLOGY

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal

(2019) Mingen Liu et al.   NATURE IMMUNOLOGY

Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor

(2019) Allison Gartung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer associated fibroblasts sculpt tumour microenvironment by recruiting monocytes and inducing immunosuppressive PD-1+ TAMs

(2019) Betul Gok Yavuz et al.   Scientific Reports

Hepatocytes direct the formation of a pro-metastatic niche in the liver

(2019) Jae W. Lee et al.   NATURE

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

(2019) Branimir I. Sikic et al.   JOURNAL OF CLINICAL ONCOLOGY

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression

(2019) Pieter Goossens et al.   Cell Metabolism

MRNA Delivery For Therapeutic Anti-Her2 Antibody Expression In Vivo

(2019) Yulia Rybakova et al.   MOLECULAR THERAPY

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

(2019) Florian R. Greten et al.   IMMUNITY

Ontogeny of Tumor-Associated Macrophages

(2019) Marie Laviron et al.   Frontiers in Immunology

Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix

(2019) Wenlong Zhang et al.   BRITISH JOURNAL OF CANCER

Understanding the Origin and Diversity of Macrophages to Tailor Their Targeting in Solid Cancers

(2019) Karoline Kielbassa et al.   Frontiers in Immunology

Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis

(2019) U Dafni et al.   ANNALS OF ONCOLOGY

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

(2019) F. Zhang et al.   Nature Communications

Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy

(2019) Abhishek S. Kashyap et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson’s Disease

(2019) Cang Chen et al.   Molecular Therapy-Methods & Clinical Development

Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles

(2018) Ying-Li Luo et al.   ACS Nano

CRISPRed Macrophages for Cell-Based Cancer Immunotherapy

(2018) Moumita Ray et al.   BIOCONJUGATE CHEMISTRY

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

(2018) Ye Li et al.   Cell Stem Cell

Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment

(2018) Jingying Zhang et al.   HEPATOLOGY

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity

(2018) Sabine Hoves et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

(2018) Elisa Peranzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy

(2018) Jordan A. Krall et al.   Science Translational Medicine

Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

(2018) Giulia Escobar et al.   Nature Communications

Chimeric antigen receptors that trigger phagocytosis

(2018) Meghan A Morrissey et al.   eLife

Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer

(2018) Jonas Steenbrugge et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Macrophages of distinct origins contribute to tumor development in the lung

(2018) Pierre-Louis Loyher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

(2018) Matthew M. Gubin et al.   CELL

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages

(2018) Shicheng Su et al.   CELL

Genetically Engineered Macrophages: A Potential Platform for Cancer Immunotherapy

(2017) Kara W. Moyes et al.   HUMAN GENE THERAPY

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

(2017) Yu Zhu et al.   IMMUNITY

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance

(2017) Donnele Daley et al.   NATURE MEDICINE

Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients

(2016) Niels Halama et al.   CANCER CELL

Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma

(2016) Anusha Kalbasi et al.   CLINICAL CANCER RESEARCH

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

Damage-associated molecular patterns in cancer: a double-edged sword

(2016) C Hernandez et al.   ONCOGENE

Interaction between Treg cells and tumor-associated macrophages in the tumor microenvironment of epithelial ovarian cancer

(2016) Qinyi Zhu et al.   ONCOLOGY REPORTS

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

(2016) D. F. Quail et al.   SCIENCE

Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

(2015) R. Hughes et al.   CANCER RESEARCH

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Engineering macrophages to control the inflammatory response and angiogenesis

(2015) K.V. Eaton et al.   EXPERIMENTAL CELL RESEARCH

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

(2015) Xiaojuan Liu et al.   NATURE MEDICINE

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

(2015) William D. Tap et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer

(2015) A. J. Gunderson et al.   Cancer Discovery

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

(2015) E. Sotillo et al.   Cancer Discovery

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

Tumors: Wounds That Do Not Heal--Redux

(2015) H. F. Dvorak   Cancer Immunology Research

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

(2014) Laura Bonapace et al.   NATURE

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis

(2014) Vladimir Riabov et al.   Frontiers in Physiology

Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression

(2014) Damya Laoui et al.   Frontiers in Immunology

Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy

(2013) Felix Klug et al.   CANCER CELL

A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors

(2013) Shahneen K. Sandhu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Adenovirus Detection by the cGAS/STING/TBK1 DNA Sensing Cascade

(2013) E. Lam et al.   JOURNAL OF VIROLOGY

Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells

(2012) John J. Engelhardt et al.   CANCER CELL

Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein

(2012) S Bobadilla et al.   GENE THERAPY

Generation of dendritic cells and macrophages from human induced pluripotent stem cells aiming at cell therapy

(2011) S Senju et al.   GENE THERAPY

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

(2011) T. Shree et al.   GENES & DEVELOPMENT

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Tumor heterogeneity: Causes and consequences

(2009) Andriy Marusyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling

(2009) Andrew J. Fleetwood et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE