WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism

Mutant WDR45 Leads to Altered Ferritinophagy and Ferroptosis in β-Propeller Protein-Associated Neurodegeneration

(2022) Sokhna Haissatou Diaw et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NCOA4: More than a receptor for ferritinophagy

(2022) Zheng Wang et al.   JOURNAL OF CELL BIOLOGY

NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy

(2022) Tomoko Ohshima et al.   JOURNAL OF CELL BIOLOGY

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

(2021) Chuan’ai Chen et al.   Cell Death & Disease

β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells

(2021) Cuicui Ji et al.   CURRENT BIOLOGY

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

(2021) Mathieu Bourdenx et al.   CELL

WDR45 Mutation Impairs the Autophagic Degradation of Transferrin Receptor and Promotes Ferroptosis

(2021) Qiuhong Xiong et al.   Frontiers in Molecular Biosciences

Compound Tongluo Decoction inhibits endoplasmic reticulum stress-induced ferroptosis and promoted angiogenesis by activating the Sonic Hedgehog pathway in cerebral infarction

(2021) Zhen Hui et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dysregulation of Iron Homeostasis in the Central Nervous System and the Role of Ferroptosis in Neurodegenerative Disorders

(2021) Samuel David et al.   ANTIOXIDANTS & REDOX SIGNALING

High-fat diet aggravates colitis-associated carcinogenesis by evading ferroptosis in the ER stress-mediated pathway

(2021) Xiaoli Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron Accumulation and Changes in Cellular Organelles in WDR45 Mutant Fibroblasts

(2021) Hye Eun Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A neurodegeneration gene, WDR45 , links impaired ferritinophagy to iron accumulation

(2021) Luisa Aring et al.   JOURNAL OF NEUROCHEMISTRY

Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis

(2020) Minyi Xu et al.   Cell Death & Disease

BAX-dependent mitochondrial pathway mediates the crosstalk between ferroptosis and apoptosis

(2020) Young-Sun Lee et al.   APOPTOSIS

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)

(2019) Philip Wing-Lok Ho et al.   Autophagy

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death

(2019) Huida Wan et al.   Autophagy

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

(2019) Philipp Kirchner et al.   PLOS BIOLOGY

Functional evidence for a de novo mutation in WDR45 leading to BPAN in a Chinese girl

(2019) Qiuhong Xiong et al.   Molecular Genetics & Genomic Medicine

To eat or not to eat — the metabolic flavor of ferroptosis

(2018) Minghui Gao et al.   CURRENT OPINION IN CELL BIOLOGY

Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

(2018) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells

(2018) Philip Seibler et al.   BRAIN

WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

(2017) Daniela Bakula et al.   Nature Communications

Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy

(2017) Wenming Li et al.   Nature Communications

Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9

(2017) Jonathan M. Goodwin et al.   Cell Reports

Ferrous Iron Up-regulation in Fibroblasts of Patients with Beta Propeller Protein-Associated Neurodegeneration (BPAN)

(2017) Rosaria Ingrassia et al.   Frontiers in Genetics

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research

(2015) Manoj B Menon et al.   Autophagy

Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases

(2014) Haijian Wu et al.   MOLECULAR NEUROBIOLOGY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

A novel crosstalk between two major protein degradation systems

(2013) Xiao J Wang et al.   Autophagy

Beta-propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation

(2013) Susan J. Hayflick et al.   BRAIN

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

(2013) Jaime Anguiano et al.   Nature Chemical Biology

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

(2013) Hirotomo Saitsu et al.   NATURE GENETICS

Exome Sequencing Reveals De Novo WDR45 Mutations Causing a Phenotypically Distinct, X-Linked Dominant Form of NBIA

(2012) Tobias B. Haack et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Heteromeric p97/p97R155C Complexes Induce Dominant Negative Changes in Wild-Type and Autophagy 9-Deficient Dictyostelium strains

(2012) Khalid Arhzaouy et al.   PLoS One

Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells

(2011) T. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

A photoconvertible fluorescent reporter to track chaperone-mediated autophagy

(2011) Hiroshi Koga et al.   Nature Communications

Lysosomal Proteolysis Is the Primary Degradation Pathway for Cytosolic Ferritin and Cytosolic Ferritin Degradation Is Necessary for Iron Exit

(2010) Yinghui Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Iron in neuronal function and dysfunction

(2010) Gabriela A. Salvador   BIOFACTORS

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL